Anthocyanin supplementation at different doses improves cholesterol efflux capacity in subjects with dyslipidemia—a randomized controlled trial

Background/objectives Numerous clinical trials have confirmed that supplementation with purified anthocyanins has favorable effects on metabolic diseases, but the dose–response of dyslipidemia to anthocyanin supplementation remains unclear. This study aimed to investigate the effect of anthocyanin s...

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Published inEuropean journal of clinical nutrition Vol. 75; no. 2; pp. 345 - 354
Main Authors Xu, Zhongliang, Xie, Jiewen, Zhang, Hanyue, Pang, Juan, Li, Qing, Wang, Xu, Xu, Huihui, Sun, Xiaoyuan, Zhao, Huiwen, Yang, Yan, Ling, Wenhua
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.02.2021
Nature Publishing Group
Subjects
13
13/95
692/699/317
692/700/2814
Adult
Aged
Analysis
Anthocyanin
Anthocyanins
Apolipoprotein A
Apolipoprotein A-I
Apolipoproteins
Cholesterol
Cholesterol, HDL
Clinical Nutrition
Clinical trials
Dietary Supplements
Dosage and administration
Dyslipidemia
Dyslipidemias - drug therapy
Efflux
Epidemiology
High density lipoprotein
Humans
Internal Medicine
Lipids
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolic disorders
Middle Aged
Placebos
Public Health
Supplements
Trend analysis
China
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Abstract Background/objectives Numerous clinical trials have confirmed that supplementation with purified anthocyanins has favorable effects on metabolic diseases, but the dose–response of dyslipidemia to anthocyanin supplementation remains unclear. This study aimed to investigate the effect of anthocyanin supplementation in different doses on lipid profile. Subjects/methods We randomly assigned 176 dyslipidemic subjects aged 35–70 to three purified anthocyanin groups (40 mg/day, n  = 45; 80 mg/day, n  = 42; 320 mg/day, n  = 43) and a placebo group ( n  = 46). Anthropometric parameters, serum lipid profiles, and cholesterol efflux capacity (CEC) were measured at baseline, and at the end of 6 and 12 weeks. Results After 12 weeks of supplementation, significant differences in CEC ( P  = 0.033), high-density lipoprotein cholesterol (HDL-C) ( P  = 0.043), and apolipoprotein A-I (ApoA-I) ( P  = 0.022) were observed between four groups. Compared with placebo, 320 mg/day anthocyanin significantly increased CEC (35.8%, 95% CI: 11.5–60.2%; P  = 0.004), HDL-C (0.07 mmol/L, 95% CI: 0.01–0.14; P  = 0.003), and ApoA-I (0.07 g/L, 95% CI: 0.01–0.12; P  = 0.008). Linear trend analysis showed that anthocyanin supplementation has a strong dose–response relationship with CEC ( P  = 0.002), HDL-C ( P  = 0.038), and ApoA-I ( P  = 0.023). Moreover, the enhancement of CEC showed positive correlations with the increase in HDL-C ( r  = 0.215, P  < 0.01) and APOA-I ( r  = 0.327, P  < 0.01). Conclusions Anthocyanin supplementation at 0–320 mg/day for 12 weeks enhances CEC in a dose–response manner in dyslipidemic subjects. Anthocyanin supplementation doses of 80–320 mg/day can improve serum HDL-C levels and HDL-induced CEC.
AbstractList Numerous clinical trials have confirmed that supplementation with purified anthocyanins has favorable effects on metabolic diseases, but the dose-response of dyslipidemia to anthocyanin supplementation remains unclear. This study aimed to investigate the effect of anthocyanin supplementation in different doses on lipid profile. After 12 weeks of supplementation, significant differences in CEC (P = 0.033), high-density lipoprotein cholesterol (HDL-C) (P = 0.043), and apolipoprotein A-I (ApoA-I) (P = 0.022) were observed between four groups. Compared with placebo, 320 mg/day anthocyanin significantly increased CEC (35.8%, 95% CI: 11.5-60.2%; P = 0.004), HDL-C (0.07 mmol/L, 95% CI: 0.01-0.14; P = 0.003), and ApoA-I (0.07 g/L, 95% CI: 0.01-0.12; P = 0.008). Linear trend analysis showed that anthocyanin supplementation has a strong dose-response relationship with CEC (P = 0.002), HDL-C (P = 0.038), and ApoA-I (P = 0.023). Moreover, the enhancement of CEC showed positive correlations with the increase in HDL-C (r = 0.215, P < 0.01) and APOA-I (r = 0.327, P < 0.01). Anthocyanin supplementation at 0-320 mg/day for 12 weeks enhances CEC in a dose-response manner in dyslipidemic subjects. Anthocyanin supplementation doses of 80-320 mg/day can improve serum HDL-C levels and HDL-induced CEC.
Background/objectives Numerous clinical trials have confirmed that supplementation with purified anthocyanins has favorable effects on metabolic diseases, but the dose-response of dyslipidemia to anthocyanin supplementation remains unclear. This study aimed to investigate the effect of anthocyanin supplementation in different doses on lipid profile. Subjects/methods We randomly assigned 176 dyslipidemic subjects aged 35-70 to three purified anthocyanin groups (40 mg/day, n = 45; 80 mg/day, n = 42; 320 mg/day, n = 43) and a placebo group (n = 46). Anthropometric parameters, serum lipid profiles, and cholesterol efflux capacity (CEC) were measured at baseline, and at the end of 6 and 12 weeks. Results After 12 weeks of supplementation, significant differences in CEC (P = 0.033), high-density lipoprotein cholesterol (HDL-C) (P = 0.043), and apolipoprotein A-I (ApoA-I) (P = 0.022) were observed between four groups. Compared with placebo, 320 mg/day anthocyanin significantly increased CEC (35.8%, 95% CI: 11.5-60.2%; P = 0.004), HDL-C (0.07 mmol/L, 95% CI: 0.01-0.14; P = 0.003), and ApoA-I (0.07 g/L, 95% CI: 0.01-0.12; P = 0.008). Linear trend analysis showed that anthocyanin supplementation has a strong dose-response relationship with CEC (P = 0.002), HDL-C (P = 0.038), and ApoA-I (P = 0.023). Moreover, the enhancement of CEC showed positive correlations with the increase in HDL-C (r = 0.215, P < 0.01) and APOA-I (r = 0.327, P < 0.01). Conclusions Anthocyanin supplementation at 0-320 mg/day for 12 weeks enhances CEC in a dose-response manner in dyslipidemic subjects. Anthocyanin supplementation doses of 80-320 mg/day can improve serum HDL-C levels and HDL-induced CEC.
Background/objectives Numerous clinical trials have confirmed that supplementation with purified anthocyanins has favorable effects on metabolic diseases, but the dose–response of dyslipidemia to anthocyanin supplementation remains unclear. This study aimed to investigate the effect of anthocyanin supplementation in different doses on lipid profile. Subjects/methods We randomly assigned 176 dyslipidemic subjects aged 35–70 to three purified anthocyanin groups (40 mg/day, n  = 45; 80 mg/day, n  = 42; 320 mg/day, n  = 43) and a placebo group ( n  = 46). Anthropometric parameters, serum lipid profiles, and cholesterol efflux capacity (CEC) were measured at baseline, and at the end of 6 and 12 weeks. Results After 12 weeks of supplementation, significant differences in CEC ( P  = 0.033), high-density lipoprotein cholesterol (HDL-C) ( P  = 0.043), and apolipoprotein A-I (ApoA-I) ( P  = 0.022) were observed between four groups. Compared with placebo, 320 mg/day anthocyanin significantly increased CEC (35.8%, 95% CI: 11.5–60.2%; P  = 0.004), HDL-C (0.07 mmol/L, 95% CI: 0.01–0.14; P  = 0.003), and ApoA-I (0.07 g/L, 95% CI: 0.01–0.12; P  = 0.008). Linear trend analysis showed that anthocyanin supplementation has a strong dose–response relationship with CEC ( P  = 0.002), HDL-C ( P  = 0.038), and ApoA-I ( P  = 0.023). Moreover, the enhancement of CEC showed positive correlations with the increase in HDL-C ( r  = 0.215, P  < 0.01) and APOA-I ( r  = 0.327, P  < 0.01). Conclusions Anthocyanin supplementation at 0–320 mg/day for 12 weeks enhances CEC in a dose–response manner in dyslipidemic subjects. Anthocyanin supplementation doses of 80–320 mg/day can improve serum HDL-C levels and HDL-induced CEC.
Numerous clinical trials have confirmed that supplementation with purified anthocyanins has favorable effects on metabolic diseases, but the dose-response of dyslipidemia to anthocyanin supplementation remains unclear. This study aimed to investigate the effect of anthocyanin supplementation in different doses on lipid profile.BACKGROUND/OBJECTIVESNumerous clinical trials have confirmed that supplementation with purified anthocyanins has favorable effects on metabolic diseases, but the dose-response of dyslipidemia to anthocyanin supplementation remains unclear. This study aimed to investigate the effect of anthocyanin supplementation in different doses on lipid profile.We randomly assigned 176 dyslipidemic subjects aged 35-70 to three purified anthocyanin groups (40 mg/day, n = 45; 80 mg/day, n = 42; 320 mg/day, n = 43) and a placebo group (n = 46). Anthropometric parameters, serum lipid profiles, and cholesterol efflux capacity (CEC) were measured at baseline, and at the end of 6 and 12 weeks.SUBJECTS/METHODSWe randomly assigned 176 dyslipidemic subjects aged 35-70 to three purified anthocyanin groups (40 mg/day, n = 45; 80 mg/day, n = 42; 320 mg/day, n = 43) and a placebo group (n = 46). Anthropometric parameters, serum lipid profiles, and cholesterol efflux capacity (CEC) were measured at baseline, and at the end of 6 and 12 weeks.After 12 weeks of supplementation, significant differences in CEC (P = 0.033), high-density lipoprotein cholesterol (HDL-C) (P = 0.043), and apolipoprotein A-I (ApoA-I) (P = 0.022) were observed between four groups. Compared with placebo, 320 mg/day anthocyanin significantly increased CEC (35.8%, 95% CI: 11.5-60.2%; P = 0.004), HDL-C (0.07 mmol/L, 95% CI: 0.01-0.14; P = 0.003), and ApoA-I (0.07 g/L, 95% CI: 0.01-0.12; P = 0.008). Linear trend analysis showed that anthocyanin supplementation has a strong dose-response relationship with CEC (P = 0.002), HDL-C (P = 0.038), and ApoA-I (P = 0.023). Moreover, the enhancement of CEC showed positive correlations with the increase in HDL-C (r = 0.215, P < 0.01) and APOA-I (r = 0.327, P < 0.01).RESULTSAfter 12 weeks of supplementation, significant differences in CEC (P = 0.033), high-density lipoprotein cholesterol (HDL-C) (P = 0.043), and apolipoprotein A-I (ApoA-I) (P = 0.022) were observed between four groups. Compared with placebo, 320 mg/day anthocyanin significantly increased CEC (35.8%, 95% CI: 11.5-60.2%; P = 0.004), HDL-C (0.07 mmol/L, 95% CI: 0.01-0.14; P = 0.003), and ApoA-I (0.07 g/L, 95% CI: 0.01-0.12; P = 0.008). Linear trend analysis showed that anthocyanin supplementation has a strong dose-response relationship with CEC (P = 0.002), HDL-C (P = 0.038), and ApoA-I (P = 0.023). Moreover, the enhancement of CEC showed positive correlations with the increase in HDL-C (r = 0.215, P < 0.01) and APOA-I (r = 0.327, P < 0.01).Anthocyanin supplementation at 0-320 mg/day for 12 weeks enhances CEC in a dose-response manner in dyslipidemic subjects. Anthocyanin supplementation doses of 80-320 mg/day can improve serum HDL-C levels and HDL-induced CEC.CONCLUSIONSAnthocyanin supplementation at 0-320 mg/day for 12 weeks enhances CEC in a dose-response manner in dyslipidemic subjects. Anthocyanin supplementation doses of 80-320 mg/day can improve serum HDL-C levels and HDL-induced CEC.
Numerous clinical trials have confirmed that supplementation with purified anthocyanins has favorable effects on metabolic diseases, but the dose-response of dyslipidemia to anthocyanin supplementation remains unclear. This study aimed to investigate the effect of anthocyanin supplementation in different doses on lipid profile. We randomly assigned 176 dyslipidemic subjects aged 35-70 to three purified anthocyanin groups (40 mg/day, n = 45; 80 mg/day, n = 42; 320 mg/day, n = 43) and a placebo group (n = 46). Anthropometric parameters, serum lipid profiles, and cholesterol efflux capacity (CEC) were measured at baseline, and at the end of 6 and 12 weeks. After 12 weeks of supplementation, significant differences in CEC (P = 0.033), high-density lipoprotein cholesterol (HDL-C) (P = 0.043), and apolipoprotein A-I (ApoA-I) (P = 0.022) were observed between four groups. Compared with placebo, 320 mg/day anthocyanin significantly increased CEC (35.8%, 95% CI: 11.5-60.2%; P = 0.004), HDL-C (0.07 mmol/L, 95% CI: 0.01-0.14; P = 0.003), and ApoA-I (0.07 g/L, 95% CI: 0.01-0.12; P = 0.008). Linear trend analysis showed that anthocyanin supplementation has a strong dose-response relationship with CEC (P = 0.002), HDL-C (P = 0.038), and ApoA-I (P = 0.023). Moreover, the enhancement of CEC showed positive correlations with the increase in HDL-C (r = 0.215, P < 0.01) and APOA-I (r = 0.327, P < 0.01). Anthocyanin supplementation at 0-320 mg/day for 12 weeks enhances CEC in a dose-response manner in dyslipidemic subjects. Anthocyanin supplementation doses of 80-320 mg/day can improve serum HDL-C levels and HDL-induced CEC.
Background/objectivesNumerous clinical trials have confirmed that supplementation with purified anthocyanins has favorable effects on metabolic diseases, but the dose–response of dyslipidemia to anthocyanin supplementation remains unclear. This study aimed to investigate the effect of anthocyanin supplementation in different doses on lipid profile.Subjects/methodsWe randomly assigned 176 dyslipidemic subjects aged 35–70 to three purified anthocyanin groups (40 mg/day, n = 45; 80 mg/day, n = 42; 320 mg/day, n = 43) and a placebo group (n = 46). Anthropometric parameters, serum lipid profiles, and cholesterol efflux capacity (CEC) were measured at baseline, and at the end of 6 and 12 weeks.ResultsAfter 12 weeks of supplementation, significant differences in CEC (P = 0.033), high-density lipoprotein cholesterol (HDL-C) (P = 0.043), and apolipoprotein A-I (ApoA-I) (P = 0.022) were observed between four groups. Compared with placebo, 320 mg/day anthocyanin significantly increased CEC (35.8%, 95% CI: 11.5–60.2%; P = 0.004), HDL-C (0.07 mmol/L, 95% CI: 0.01–0.14; P = 0.003), and ApoA-I (0.07 g/L, 95% CI: 0.01–0.12; P = 0.008). Linear trend analysis showed that anthocyanin supplementation has a strong dose–response relationship with CEC (P = 0.002), HDL-C (P = 0.038), and ApoA-I (P = 0.023). Moreover, the enhancement of CEC showed positive correlations with the increase in HDL-C (r = 0.215, P < 0.01) and APOA-I (r = 0.327, P < 0.01).ConclusionsAnthocyanin supplementation at 0–320 mg/day for 12 weeks enhances CEC in a dose–response manner in dyslipidemic subjects. Anthocyanin supplementation doses of 80–320 mg/day can improve serum HDL-C levels and HDL-induced CEC.
Audience Professional
Academic
Author Wang, Xu
Zhao, Huiwen
Li, Qing
Pang, Juan
Sun, Xiaoyuan
Xu, Zhongliang
Xie, Jiewen
Yang, Yan
Zhang, Hanyue
Ling, Wenhua
Xu, Huihui
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/32317748$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
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COPYRIGHT 2021 Nature Publishing Group
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Snippet Background/objectives Numerous clinical trials have confirmed that supplementation with purified anthocyanins has favorable effects on metabolic diseases, but...
Numerous clinical trials have confirmed that supplementation with purified anthocyanins has favorable effects on metabolic diseases, but the dose-response of...
Background/objectives Numerous clinical trials have confirmed that supplementation with purified anthocyanins has favorable effects on metabolic diseases, but...
Background/objectivesNumerous clinical trials have confirmed that supplementation with purified anthocyanins has favorable effects on metabolic diseases, but...
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StartPage 345
SubjectTerms 13
13/95
692/699/317
692/700/2814
Adult
Aged
Analysis
Anthocyanin
Anthocyanins
Apolipoprotein A
Apolipoprotein A-I
Apolipoproteins
Cholesterol
Cholesterol, HDL
Clinical Nutrition
Clinical trials
Dietary Supplements
Dosage and administration
Dyslipidemia
Dyslipidemias - drug therapy
Efflux
Epidemiology
High density lipoprotein
Humans
Internal Medicine
Lipids
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolic disorders
Middle Aged
Placebos
Public Health
Supplements
Trend analysis
Title Anthocyanin supplementation at different doses improves cholesterol efflux capacity in subjects with dyslipidemia—a randomized controlled trial
URI https://link.springer.com/article/10.1038/s41430-020-0609-4
https://www.ncbi.nlm.nih.gov/pubmed/32317748
https://www.proquest.com/docview/2488036778
https://www.proquest.com/docview/2393634421
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