The Acylation State of Surface Lipoproteins of Mollicute Acholeplasma laidlawii
Acylation of the N-terminal Cys residue is an essential, ubiquitous, and uniquely bacterial posttranslational modification that allows anchoring of proteins to the lipid membrane. In Gram-negative bacteria, acylation proceeds through three sequential steps requiring lipoprotein diacylglyceryltransfe...
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Published in | The Journal of biological chemistry Vol. 286; no. 26; pp. 22769 - 22776 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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01.07.2011
American Society for Biochemistry and Molecular Biology |
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Abstract | Acylation of the N-terminal Cys residue is an essential, ubiquitous, and uniquely bacterial posttranslational modification that allows anchoring of proteins to the lipid membrane. In Gram-negative bacteria, acylation proceeds through three sequential steps requiring lipoprotein diacylglyceryltransferase, lipoprotein signal peptidase, and finally lipoprotein N-acyltransferase. The apparent lack of genes coding for recognizable homologs of lipoprotein N-acyltransferase in Gram-positive bacteria and Mollicutes suggests that the final step of the protein acylation process may be absent in these organisms. In this work, we monitored the acylation state of eight major lipoproteins of the mollicute Acholeplasma laidlawii using a combination of standard two-dimensional gel electrophoresis protein separation, blotting to nitrocellulose membranes, and MALDI-MS identification of modified N-terminal tryptic peptides. We show that for each A. laidlawii lipoprotein studied a third fatty acid in an amide linkage on the N-terminal Cys residue is present, whereas diacylated species were not detected. The result thus proves that A. laidlawii encodes a lipoprotein N-acyltransferase activity. We hypothesize that N-acyltransferases encoded by genes non-homologous to N-acyltransferases of Gram-negative bacteria are also present in other mollicutes and Gram-positive bacteria. |
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AbstractList | Acylation of the N-terminal Cys residue is an essential, ubiquitous, and uniquely bacterial posttranslational modification that allows anchoring of proteins to the lipid membrane. In Gram-negative bacteria, acylation proceeds through three sequential steps requiring lipoprotein diacylglyceryltransferase, lipoprotein signal peptidase, and finally lipoprotein N-acyltransferase. The apparent lack of genes coding for recognizable homologs of lipoprotein N-acyltransferase in Gram-positive bacteria and Mollicutes suggests that the final step of the protein acylation process may be absent in these organisms. In this work, we monitored the acylation state of eight major lipoproteins of the mollicute Acholeplasma laidlawii using a combination of standard two-dimensional gel electrophoresis protein separation, blotting to nitrocellulose membranes, and MALDI-MS identification of modified N-terminal tryptic peptides. We show that for each A. laidlawii lipoprotein studied a third fatty acid in an amide linkage on the N-terminal Cys residue is present, whereas diacylated species were not detected. The result thus proves that A. laidlawii encodes a lipoprotein N-acyltransferase activity. We hypothesize that N-acyltransferases encoded by genes non-homologous to N-acyltransferases of Gram-negative bacteria are also present in other mollicutes and Gram-positive bacteria. Acylation of the N-terminal Cys residue is an essential, ubiquitous, and uniquely bacterial posttranslational modification that allows anchoring of proteins to the lipid membrane. In Gram-negative bacteria, acylation proceeds through three sequential steps requiring lipoprotein diacylglyceryltransferase, lipoprotein signal peptidase, and finally lipoprotein N -acyltransferase. The apparent lack of genes coding for recognizable homologs of lipoprotein N -acyltransferase in Gram-positive bacteria and Mollicutes suggests that the final step of the protein acylation process may be absent in these organisms. In this work, we monitored the acylation state of eight major lipoproteins of the mollicute Acholeplasma laidlawii using a combination of standard two-dimensional gel electrophoresis protein separation, blotting to nitrocellulose membranes, and MALDI-MS identification of modified N-terminal tryptic peptides. We show that for each A. laidlawii lipoprotein studied a third fatty acid in an amide linkage on the N-terminal Cys residue is present, whereas diacylated species were not detected. The result thus proves that A. laidlawii encodes a lipoprotein N -acyltransferase activity. We hypothesize that N -acyltransferases encoded by genes non-homologous to N -acyltransferases of Gram-negative bacteria are also present in other mollicutes and Gram-positive bacteria. |
Author | Ladygina, Valentina G. Demina, Irina A. Galyamina, Maria A. Kondratov, Ilya G. Govorun, Vadim M. Serebryakova, Marina V. |
Author_xml | – sequence: 1 givenname: Marina V. surname: Serebryakova fullname: Serebryakova, Marina V. email: mserebr@mail.ru organization: Institute of Physico-Chemical Medicine, Federal Medico-Biological Agency, Moscow 119992, Russia – sequence: 2 givenname: Irina A. surname: Demina fullname: Demina, Irina A. organization: Institute of Physico-Chemical Medicine, Federal Medico-Biological Agency, Moscow 119992, Russia – sequence: 3 givenname: Maria A. surname: Galyamina fullname: Galyamina, Maria A. organization: Institute of Physico-Chemical Medicine, Federal Medico-Biological Agency, Moscow 119992, Russia – sequence: 4 givenname: Ilya G. surname: Kondratov fullname: Kondratov, Ilya G. organization: Institute of Physico-Chemical Medicine, Federal Medico-Biological Agency, Moscow 119992, Russia – sequence: 5 givenname: Valentina G. surname: Ladygina fullname: Ladygina, Valentina G. organization: Institute of Physico-Chemical Medicine, Federal Medico-Biological Agency, Moscow 119992, Russia – sequence: 6 givenname: Vadim M. surname: Govorun fullname: Govorun, Vadim M. organization: Institute of Physico-Chemical Medicine, Federal Medico-Biological Agency, Moscow 119992, Russia |
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DocumentTitleAlternate | Acylation State of A. laidlawii Lipoproteins |
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Keywords | Membrane Proteins Mass Spectrometry (MS) Bacteria Lipoprotein 2D PAGE Fatty Acid |
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SubjectTerms | 2D PAGE Acetylation Acholeplasma laidlawii - chemistry Acholeplasma laidlawii - genetics Acholeplasma laidlawii - metabolism Acyltransferases - chemistry Acyltransferases - genetics Acyltransferases - metabolism Bacteria Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Fatty Acid Lipoprotein Lipoproteins - chemistry Lipoproteins - genetics Lipoproteins - metabolism Mass Spectrometry (MS) Membrane Biology Membrane Proteins Protein Processing, Post-Translational - physiology |
Title | The Acylation State of Surface Lipoproteins of Mollicute Acholeplasma laidlawii |
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