Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis

• Published in: Nature communications Vol. 6; no. 1; p. 6253
• Main Authors: Srivastava, Monika, Duan, Guowen, Kershaw, Nadia J., Athanasopoulos, Vicki, Yeo, Janet H. C., Ose, Toyoyuki, Hu, Desheng, Brown, Simon H. J., Jergic, Slobodan, Patel, Hardip R., Pratama, Alvin, Richards, Sashika, Verma, Anil, Jones, E. Yvonne, Heissmeyer, Vigo, Preiss, Thomas, Dixon, Nicholas E., Chong, Mark M. W., Babon, Jeffrey J., Vinuesa, Carola G.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.02.2015; Nature Publishing Group; Nature Pub. Group
• Subjects: 13; 13/1; 13/106; 13/109; 13/31; 13/44; 13/51; 14/19; 14/63; 38/22; 38/32; 38/39; 38/61; 38/90; 38/91; 631/250/1619/554/1898/1270; 631/337/384/331; 631/45/612/1230; 64/60; 82/103; 82/6; 82/83; Animals; Argonaute Proteins - metabolism; Bone marrow; Crystallography, X-Ray; Genomes; Half-Life; HEK293 Cells; Homeostasis; Humanities and Social Sciences; Humans; Immunology; Localization; Lymphocytes; Medical research; Mice, Inbred C57BL; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; multidisciplinary; Mutation; Protein Binding - genetics; Protein Structure, Tertiary; Proteins; Ribonuclease III - metabolism; RNA Processing, Post-Transcriptional; RNA Stability; Science; Science (multidisciplinary); T-Lymphocytes - metabolism; Ubiquitin-Protein Ligases - chemistry; Ubiquitin-Protein Ligases - metabolism; Australia; Canberra Australian Capital Territory Australia; Germany; Australian Capital Territory Australia; New South Wales Australia

Roquin is an RNA-binding protein that prevents autoimmunity and inflammation via repression of bound target mRNAs such as inducible costimulator ( Icos ). When Roquin is absent or mutated (Roquin san ), Icos is overexpressed in T cells. Here we show that Roquin enhances Dicer-mediated processing of...