Single-cell RNA sequencing reveals B cell–related molecular biomarkers for Alzheimer’s disease

• Published in: Experimental & molecular medicine Vol. 53; no. 12; pp. 1888 - 1901
• Main Authors: Xiong, Liu-Lin, Xue, Lu-Lu, Du, Ruo-Lan, Niu, Rui-Ze, Chen, Li, Chen, Jie, Hu, Qiao, Tan, Ya-Xin, Shang, Hui-Fang, Liu, Jia, Yu, Chang-Yin, Wang, Ting-Hua
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2021; Springer Nature B.V; 생화학분자생물학회
• Subjects: 38/91; 631/378/1686; 631/378/1934; Alzheimer Disease - etiology; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid beta-Peptides - genetics; Amyloid beta-Peptides - metabolism; Animal models; Animals; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Biomarkers; Biomedical and Life Sciences; Biomedicine; Cognitive ability; Computational Biology; Correlation analysis; Dementia disorders; Flow cytometry; Gene Expression Profiling; High-Throughput Nucleotide Sequencing; Humans; Leukocytes (mononuclear); Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - metabolism; Lymphocytes B; Medical Biochemistry; Mice; Molecular Medicine; Neurodegenerative diseases; Patients; Peripheral blood mononuclear cells; Plaques; Ribonucleic acid; RNA; Sequence analysis; Single-Cell Analysis; Stem Cells; 생화학

In recent years, biomarkers have been integrated into the diagnostic process and have become increasingly indispensable for obtaining knowledge of the neurodegenerative processes in Alzheimer’s disease (AD). Peripheral blood mononuclear cells (PBMCs) in human blood have been reported to participate...