Ahnak deficiency attenuates high-fat diet-induced fatty liver in mice through FGF21 induction

• Published in: Experimental & molecular medicine Vol. 53; no. 3; pp. 468 - 482
• Main Authors: Kim, Yo Na, Shin, Jae Hoon, Kyeong, Dong Soo, Cho, Soo Young, Kim, Mi-Young, Lim, Hee Jung, Jimenez, Maria Raquel Rojas, Kim, Il Yong, Lee, Mi-Ock, Bae, Yun Soo, Seong, Je Kyung
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2021; Springer Nature B.V; 생화학분자생물학회
• Subjects: 13; 631/443/319/1642/2037; 631/80/304; 64/60; 82/80; 9/10; Adipose tissue; Animals; Biomedical and Life Sciences; Biomedicine; Cirrhosis; Diet, High-Fat - adverse effects; Fatty acids; Fatty liver; Fatty Liver - etiology; Fatty Liver - metabolism; Fatty Liver - pathology; Fatty Liver - prevention & control; Fibroblast growth factors; Fibroblast Growth Factors - agonists; Gene expression; Hepatocytes; High fat diet; Lipid Metabolism; Lipids; Lipogenesis; Liver cirrhosis; Liver diseases; Male; Medical Biochemistry; Membrane Proteins - physiology; Metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Medicine; Neoplasm Proteins - physiology; Nutrient deficiency; Obesity; Oxidation; Palmitic acid; Proteins; Steatosis; Stem Cells; Therapeutic applications; 생화학

The AHNAK nucleoprotein has been determined to exert an anti-obesity effect in adipose tissue and further inhibit adipogenic differentiation. In this study, we examined the role of AHNAK in regulating hepatic lipid metabolism to prevent diet-induced fatty liver. Ahnak KO mice have reportedly exhibit...