Uric acid to albumin ratio as a novel predictor for coronary slow flow phenomenon in patients with chronic coronary syndrome and non-obstructive coronary arteries

• Published in: BMC cardiovascular disorders Vol. 24; no. 1; pp. 358 - 7
• Main Authors: Zhang, Xiao-jiao, Hou, Ai-jie, Luan, Bo, Wang, Cheng-fu, Li, Jia-jin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.07.2024; BioMed Central; BMC
• Subjects: Aged; Albumin; Angina pectoris; Angiography; Atherosclerosis; Biomarkers - blood; Blood; Blood flow; Cardiovascular disease; Case-Control Studies; Cholesterol; Chronic coronary syndrome; Chronic Disease; Complications and side effects; Contrast agents; Coronary Angiography; Coronary artery; Coronary artery disease; Coronary Artery Disease - blood; Coronary Artery Disease - diagnosis; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - physiopathology; Coronary Circulation; Coronary heart disease; Coronary slow flow phenomenon; Coronary vessels; Coronary Vessels - diagnostic imaging; Coronary Vessels - physiopathology; Diagnosis; Female; Health aspects; Heart attacks; Humans; Hypertension; Laboratories; Logistics; Male; Measurement; Medical examination; Medical imaging; Middle Aged; No-Reflow Phenomenon - blood; No-Reflow Phenomenon - diagnosis; No-Reflow Phenomenon - diagnostic imaging; No-Reflow Phenomenon - etiology; No-Reflow Phenomenon - physiopathology; Pathophysiology; Plasma; Predictive Value of Tests; Predictors; Regression analysis; Retrospective Studies; Risk Factors; Serum Albumin, Human - analysis; Stenosis; Trinucleotide repeats; Uric acid; Uric Acid - blood; Uric acid to albumin ratio; China; Uric acid to albumin ratio; Coronary slow flow phenomenon; Chronic coronary syndrome; Coronary artery disease; Predictors
• DOI: 10.1186/s12872-024-04040-5
• ISSN: 1471-2261

The plasma uric acid to albumin ratio (UAR) is considered as a novel indicator for Inflammation. However, the association between UAR and coronary slow flow phenomenon (CSFP) remains unclear. A total of 1328 individuals with chronic coronary syndrome (CCS) receiving coronary angiography (CAG) and found no obvious obstructive stenosis (< 40%) were included in this study. 79 individuals developed CSFP and were divided into CSFP group. The 1:2 age-matched patients with normal coronary blood flow were allocated to the control group (n = 158). The clinical characteristics, laboratory parameters including uric acid, albumin ratio, UAR and the angiographic characteristics were compared between the two groups. Patients with CSFP had a higher level of uric acid (392.3 ± 85.3 vs. 273.8 ± 71.5, P < 0.001), UAR (10.7 ± 2.2 vs. 7.2 ± 1.9, P < 0.001), but a lower level of plasma albumin (36.9 ± 4.2 vs. 38.5 ± 3.6, P = 0.003). Moreover, UAR increased as the numbers of vessels involved in CSFP increased. The logistic regression analysis demonstrated that UAR was independent predictors for CSFP. The Receiver operating characteristic (ROC) curve analysis showed that when UAR was more than 7.9, the AUC was 0.883 (95% CI: 0.840-0.927, p < 0.001), with the sensitivity and specificity were 78.2% and 88.2% respectively. Combined uric acid with plasma albumin, UAR could serve as an independent predictor for CSFP.