Role of the Gut Microbiome in Modulating Arthritis Progression in Mice

• Published in: Scientific reports Vol. 6; no. 1; p. 30594
• Main Authors: Liu, Xiaofei, Zeng, Benhua, Zhang, Juan, Li, Wenxia, Mou, Fangxiang, Wang, Heng, Zou, Qinghua, Zhong, Bing, Wu, Like, Wei, Hong, Fang, Yongfei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.08.2016; Nature Publishing Group
• Subjects: 13/31; 45; 45/91; 631/326/2565/2134; 692/4023/1670/498; Animals; Arthritis; Arthritis, Experimental - chemically induced; Arthritis, Experimental - immunology; Arthritis, Experimental - microbiology; Bacteria - classification; Bacteria - genetics; CD8 antigen; Collagen; Dendritic cells; Digestive system; Disease Models, Animal; Disease Progression; DNA, Bacterial - genetics; DNA, Ribosomal - genetics; Environmental factors; Gastrointestinal Microbiome; Genetics; Germ-Free Life; Germfree; Helper cells; Humanities and Social Sciences; Humans; Interleukin 17; Interleukin-17 - blood; Intestinal microflora; Lymphocytes; Lymphocytes B; Lymphocytes T; Mice; Mice, Inbred DBA; Microbiota; multidisciplinary; Phylogeny; Rheumatoid arthritis; RNA, Ribosomal, 16S - genetics; Rodents; rRNA 16S; Science; Science (multidisciplinary); Sequence Analysis, DNA - methods; Spleen

Genetics alone cannot explain most cases of rheumatoid arthritis (RA). Thus, investigating environmental factors such as the gut microbiota may provide new insights into the initiation and progression of RA. In this study, we performed 16S rRNA sequencing to characterise the gut microbiota of DBA1 m...