The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies

• Published in: Molecular psychiatry Vol. 26; no. 8; pp. 4158 - 4178
• Main Authors: Marx, Wolfgang, McGuinness, Amelia J., Rocks, Tetyana, Ruusunen, Anu, Cleminson, Jasmine, Walker, Adam J., Gomes-da-Costa, Susana, Lane, Melissa, Sanches, Marsal, Diaz, Alexandre P., Tseng, Ping-Tao, Lin, Pao-Yen, Berk, Michael, Clarke, Gerard, O’Neil, Adrienne, Jacka, Felice, Stubbs, Brendon, Carvalho, André F., Quevedo, João, Soares, Jair C., Fernandes, Brisa S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2021; Nature Publishing Group
• Subjects: 631/378; 692/53/2421; Acids; Behavioral Sciences; Biological Psychology; Bipolar Disorder; Depressive Disorder, Major; Development and progression; Emotional disorders; Health aspects; Humans; Kynurenic Acid; Kynurenine; Major depressive disorder; Medicine; Medicine & Public Health; Mental depression; Mental disorders; Meta-analysis; Metabolism; Metabolites; Mood; Mood disorders; Neuroprotection; Neurosciences; Neurotoxicity; Pharmacotherapy; Physiological aspects; Psychiatry; Quinolinic acid; Schizophrenia; Serotonin; Systematic review; Tryptophan; Tryptophan metabolism; United States

The importance of tryptophan as a precursor for neuroactive compounds has long been acknowledged. The metabolism of tryptophan along the kynurenine pathway and its involvement in mental disorders is an emerging area in psychiatry. We performed a meta-analysis to examine the differences in kynurenine...