Nodular Regenerative Hyperplasia in Patients Undergoing Liver Resection for Colorectal Metastases After Chemotherapy: Risk Factors, Preoperative Assessment and Clinical Impact

• Published in: Annals of surgical oncology Vol. 22; no. 13; pp. 4149 - 4157
• Main Authors: Viganò, Luca, Rubbia-Brandt, Laura, De Rosa, Giovanni, Majno, Pietro, Langella, Serena, Toso, Christian, Mentha, Gilles, Capussotti, Lorenzo
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2015; Springer Nature B.V
• Subjects: Aged; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Chemotherapy, Adjuvant; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - secondary; Colorectal Neoplasms - surgery; Combined Modality Therapy; Female; Focal Nodular Hyperplasia - diagnosis; Focal Nodular Hyperplasia - etiology; Follow-Up Studies; Hepatectomy; Hepatobiliary Tumors; Humans; Liver Neoplasms - drug therapy; Liver Neoplasms - pathology; Liver Neoplasms - surgery; Liver Regeneration; Male; Medicine; Medicine & Public Health; Neoplasm Staging; Oncology; Postoperative Complications; Preoperative Care; Prognosis; Risk Factors; Surgery; Surgical Oncology; Portal Hypertension; Oxaliplatin; Liver Resection; Major Hepatectomy; Bevacizumab

Background Nodular regenerative hyperplasia (NRH) is a severe form of chemotherapy-related liver injury (CALI) that may worsen the short-term outcome of liver resection (LR) for colorectal metastases (CRLM). The present study aimed to clarify the incidence, risk factors, preoperative assessment, and...