COVID-19 induces more pronounced extracellular matrix deposition than other causes of ARDS

• Published in: Respiratory research Vol. 24; no. 1; pp. 281 - 11
• Main Authors: de Souza Xavier Costa, Natália, Ribeiro Júnior, Gabriel, do Nascimento, Ellen Caroline Toledo, de Brito, Jôse Mara, Antonangelo, Leila, Faria, Caroline Silvério, Monteiro, Jhonatas Sirino, Setubal, João Carlos, Pinho, João Renato Rebello, Pereira, Roberta Verciano, Seelaender, Marilia, de Castro, Gabriela Salim, Lima, Joanna D. C. C., de Almeida Monteiro, Renata Aparecida, Duarte-Neto, Amaro Nunes, Saldiva, Paulo Hilário Nascimento, Ferraz da Silva, Luiz Fernando, Dolhnikoff, Marisa, Mauad, Thais
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.11.2023; BioMed Central; BMC
• Subjects: Abnormalities; Acute respiratory distress syndrome; Analysis; Autopsies; Autopsy; Biopsy; Care and treatment; Chemokines; Collagen; Collagen - metabolism; COVID-19; COVID-19 - metabolism; Cytokines; Decorin; Deposition; Diagnosis; Extracellular matrix; Extracellular Matrix - metabolism; Fatalities; Female; Fibrillogenesis; Fibronectin; Fibrosis; Gene expression; Homeostasis; Humans; Lung - metabolism; Lung fibrosis; Lungs; Mechanical ventilation; Mortality; Pulmonary Fibrosis - metabolism; Respiratory Distress Syndrome - metabolism; Severe acute respiratory syndrome coronavirus 2; Software; Substrates; Transcriptomics; Transforming Growth Factor beta - pharmacology; Transforming growth factor-b; Transforming growth factors; Variance analysis; Versican; United Kingdom; Brazil; United States > US; COVID-19; Extracellular matrix; Autopsy; Lung fibrosis

Lung fibrosis is a major concern in severe COVID-19 patients undergoing mechanical ventilation (MV). Lung fibrosis frequency in post-COVID syndrome is highly variable and even if the risk is proportionally small, many patients could be affected. However, there is still no data on lung extracellular...