Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design - Soldevila-Barreda, Joan J.; Romero-Canelón, Isolda; Habtemariam, Abraha; Sadler, Peter J. (Nature communications, 2015)
Keywords: 140/131; 631/154/309/2144; 631/45/603; 631/67; Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Carcinoma - metabolism; Catalysis; Cell death; Cell Line; Cell Line, Tumor; Cell Proliferation - drug effects; Drug Design; Drug dosages; Drug Screening Assays, Antitumor; Female; Fibroblasts - drug effects; Formates - pharmacology; Humanities and Social Sciences; Humans; Hydrogenation; Iridium; multidisciplinary; NAD - drug effects; NAD - metabolism; Necrosis; NMR; Nuclear magnetic resonance; Organic chemicals; Organometallic Compounds - pharmacology; Ovarian cancer; Ovarian Neoplasms - metabolism; Oxidative stress; Ruthenium; Ruthenium Compounds - pharmacology; Science; Science (multidisciplinary)