Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions

• Published in: Nature chemistry Vol. 10; no. 2; pp. 212 - 217
• Main Authors: Gibard, Clémentine, Bhowmik, Subhendu, Karki, Megha, Kim, Eun-Kyong, Krishnamurthy, Ramanarayanan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2018; Springer Nature; Nature Publishing Group
• Subjects: 639/638/403; 639/638/904; 639/638/92; Amino acids; Analytical Chemistry; Biochemistry; Chemistry; Chemistry, Multidisciplinary; Chemistry/Food Science; Inorganic Chemistry; Liposomes; Oligomerization; Oligomers; Oligonucleotides; Organic Chemistry; Peptides; Phosphorylation; Physical Chemistry; Physical Sciences; Prebiotics; Science & Technology; Self-assembly; Substrates; PHOSPHATE; PHOSPHORUS; NUCLEOTIDES; EARLY EARTH; ALPHA-PHOSPHORYLATION; MONOCARBOXYLIC ACIDS; RIBONUCLEOSIDES; INTERSTELLAR PN; AQUEOUS-SOLUTION; LIFE

Prebiotic phosphorylation of (pre)biological substrates under aqueous conditions is a critical step in the origins of life. Previous investigations have had limited success and/or require unique environments that are incompatible with subsequent generation of the corresponding oligomers or higher-or...