Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions
Prebiotic phosphorylation of (pre)biological substrates under aqueous conditions is a critical step in the origins of life. Previous investigations have had limited success and/or require unique environments that are incompatible with subsequent generation of the corresponding oligomers or higher-or...
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Published in | Nature chemistry Vol. 10; no. 2; pp. 212 - 217 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
01.02.2018
Springer Nature Nature Publishing Group |
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Abstract | Prebiotic phosphorylation of (pre)biological substrates under aqueous conditions is a critical step in the origins of life. Previous investigations have had limited success and/or require unique environments that are incompatible with subsequent generation of the corresponding oligomers or higher-order structures. Here, we demonstrate that diamidophosphate (DAP)—a plausible prebiotic agent produced from trimetaphosphate—efficiently (amido)phosphorylates a wide variety of (pre)biological building blocks (nucleosides/tides, amino acids and lipid precursors) under aqueous (solution/paste) conditions, without the need for a condensing agent. Significantly, higher-order structures (oligonucleotides, peptides and liposomes) are formed under the same phosphorylation reaction conditions. This plausible prebiotic phosphorylation process under similar reaction conditions could enable the systems chemistry of the three classes of (pre)biologically relevant molecules and their oligomers, in a single-pot aqueous environment.
Phosphorylation of (pre)biological molecules in water has been a long-sought goal in prebiotic chemistry. Now, it has been demonstrated that diamidophosphate phosphorylates nucleosides, amino acids and glycerol/fatty acids in aqueous medium, while simultaneously leading to higher-order structures such as oligonucleotides, peptides and liposomes in the same reaction mixture. |
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AbstractList | Prebiotic phosphorylation of (pre)biological substrates under aqueous conditions is a critical step in the origins of life. Previous investigations have had limited success and/or require unique environments that are incompatible with subsequent generation of the corresponding oligomers or higher-order structures. Here, we demonstrate that diamidophosphate (DAP)—a plausible prebiotic agent produced from trimetaphosphate—efficiently (amido)phosphorylates a wide variety of (pre)biological building blocks (nucleosides/tides, amino acids and lipid precursors) under aqueous (solution/paste) conditions, without the need for a condensing agent. Significantly, higher-order structures (oligonucleotides, peptides and liposomes) are formed under the same phosphorylation reaction conditions. This plausible prebiotic phosphorylation process under similar reaction conditions could enable the systems chemistry of the three classes of (pre)biologically relevant molecules and their oligomers, in a single-pot aqueous environment.
Phosphorylation of (pre)biological molecules in water has been a long-sought goal in prebiotic chemistry. Now, it has been demonstrated that diamidophosphate phosphorylates nucleosides, amino acids and glycerol/fatty acids in aqueous medium, while simultaneously leading to higher-order structures such as oligonucleotides, peptides and liposomes in the same reaction mixture. Prebiotic phosphorylation of (pre)biological substrates under aqueous conditions is a critical step in the origins of life. Previous investigations have had limited success and/or require unique environments that are incompatible with subsequent generation of the corresponding oligomers or higher-order structures. Here, we demonstrate that diamidophosphate (DAP)--a plausible prebiotic agent produced from trimetaphosphate--efficiently (amido)phosphorylates a wide variety of (pre)biological building blocks (nucleosides/tides, amino acids and lipid precursors) under aqueous (solution/paste) conditions, without the need for a condensing agent. Significantly, higher-order structures (oligonucleotides, peptides and liposomes) are formed under the same phosphorylation reaction conditions. This plausible prebiotic phosphorylation process under similar reaction conditions could enable the systems chemistry of the three classes of (pre)biologically relevant molecules and their oligomers, in a single-pot aqueous environment. Prebiotic phosphorylation of (pre)biological substrates under aqueous conditions is a critical step in the origins of life. Previous investigations have had limited success and/or require unique environments which are incompatible with the subsequent generation of the corresponding oligomers or higher order structures. Here we demonstrate that diamidophosphate (DAP), a plausible prebiotic agent produced from trimetaphosphate, efficiently (amido)phosphorylates a wide variety of (pre)biological building blocks (nucleosides/tides, amino acids, and lipid precursors) under aqueous (solution/paste) conditions, without the need of a condensing agent. Significantly, higher order structures (oligonucleotides, peptides and liposomes) are formed under the same phosphorylation reaction conditions. This plausible prebiotic phosphorylation process under similar reaction conditions could enable the systems chemistry of the three classes of (pre)biologically relevant molecules, and their oligomers, in a single-pot aqueous environment. Phosphorylation of (pre)biological molecules in water has been a long-sought goal in prebiotic chemistry. Here, it is demonstrated that diamidophosphate phosphorylates nucleosides, amino acids and glycerol/fatty acids in aqueous medium, while simultaneously leading to higher-order structures (oligonucleotides, peptides and liposomes) in the same pot. |
Author | Gibard, Clémentine Krishnamurthy, Ramanarayanan Kim, Eun-Kyong Bhowmik, Subhendu Karki, Megha |
AuthorAffiliation | Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA |
AuthorAffiliation_xml | – name: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA |
Author_xml | – sequence: 1 givenname: Clémentine surname: Gibard fullname: Gibard, Clémentine organization: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road – sequence: 2 givenname: Subhendu surname: Bhowmik fullname: Bhowmik, Subhendu organization: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road – sequence: 3 givenname: Megha surname: Karki fullname: Karki, Megha organization: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road – sequence: 4 givenname: Eun-Kyong surname: Kim fullname: Kim, Eun-Kyong organization: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road – sequence: 5 givenname: Ramanarayanan orcidid: 0000-0001-5238-610X surname: Krishnamurthy fullname: Krishnamurthy, Ramanarayanan email: rkrishna@scripps.edu organization: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29359747$$D View this record in MEDLINE/PubMed |
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Keywords | PHOSPHATE PHOSPHORUS NUCLEOTIDES EARLY EARTH ALPHA-PHOSPHORYLATION MONOCARBOXYLIC ACIDS RIBONUCLEOSIDES INTERSTELLAR PN AQUEOUS-SOLUTION LIFE |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Author Contributions R.K. conceived the project. R.K., C.G., S.B., M.K. and E-K.K. designed the experiments. C.G., S.B. performed the nucleoside/nucleotide/oligonucleotide phosphorylation experiments. M.K., S.B. and C.G. performed the amino acid phosphorylation experiments. M.K. performed the liposome studies. E-K.K. and S.B. made the initial observations of DAP-mediated phosphorylation. R.K. wrote the paper with inputs from C.G., S.B., M.K and E-K. K. All authors discussed the results and commented on the manuscript. |
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Snippet | Prebiotic phosphorylation of (pre)biological substrates under aqueous conditions is a critical step in the origins of life. Previous investigations have had... Prebiotic phosphorylation of (pre) biological substrates under aqueous conditions is a critical step in the origins of life. Previous investigations have had... |
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SubjectTerms | 639/638/403 639/638/904 639/638/92 Amino acids Analytical Chemistry Biochemistry Chemistry Chemistry, Multidisciplinary Chemistry/Food Science Inorganic Chemistry Liposomes Oligomerization Oligomers Oligonucleotides Organic Chemistry Peptides Phosphorylation Physical Chemistry Physical Sciences Prebiotics Science & Technology Self-assembly Substrates |
Title | Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions |
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