Activation of Stat3 Sequence-specific DNA Binding and Transcription by p300/CREB-binding Protein-mediated Acetylation

• Published in: The Journal of biological chemistry Vol. 280; no. 12; pp. 11528 - 11534
• Main Authors: Wang, Rui, Cherukuri, Pratima, Luo, Jianyuan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 25.03.2005; American Society for Biochemistry and Molecular Biology
• Subjects: Acetylation; Active Transport, Cell Nucleus; Cells, Cultured; DNA - metabolism; DNA-Binding Proteins - metabolism; Humans; Nuclear Proteins - physiology; STAT3 Transcription Factor; Trans-Activators - metabolism; Trans-Activators - physiology; Transcription, Genetic

Signal transducers and activators of transcription (Stat) belong to a family of latent cytoplasmic factors that can be activated by tyrosine phosphorylation by members of the Jak tyrosine kinase family in response to a variety of cytokines and growth factors. Activated Stats form dimers and transloc...