Cholecystokinin Facilitates Glutamate Release by Increasing the Number of Readily Releasable Vesicles and Releasing Probability

• Published in: The Journal of Neuroscience Vol. 30; no. 15; pp. 5136 - 5148
• Main Authors: Deng, Pan-Yue, Xiao, Zhaoyang, Jha, Archana, Ramonet, David, Matsui, Toshimitsu, Leitges, Michael, Shin, Hee-Sup, Porter, James E., Geiger, Jonathan D., Lei, Saobo
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 14.04.2010
• Subjects: Animals; Calcium; Calcium - metabolism; Cholecystokinin; Cholecystokinin - metabolism; Excitatory Postsynaptic Potentials; Excitatory Postsynaptic Potentials - physiology; gamma-Aminobutyric Acid; gamma-Aminobutyric Acid - metabolism; Glutamic Acid; Glutamic Acid - metabolism; Hippocampus; Hippocampus - growth & development; Hippocampus - physiology; In Vitro Techniques; Intracellular Space; Intracellular Space - physiology; Neurons; Neurons - physiology; Potassium Channels; Potassium Channels - metabolism; Presynaptic Terminals; Presynaptic Terminals - physiology; Probability; Protein Kinase C; Protein Kinase C - metabolism; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptor, Cholecystokinin B - metabolism; Receptors, AMPA; Receptors, AMPA - metabolism; Synapses; Synapses - physiology; Synaptic Transmission; Synaptic Transmission - physiology; Synaptic Vesicles; Synaptic Vesicles - physiology; Type C Phospholipases; Type C Phospholipases - metabolism

Cholecystokinin (CCK), a neuropeptide originally discovered in the gastrointestinal tract, is abundantly distributed in the mammalian brains including the hippocampus. Whereas CCK has been shown to increase glutamate concentration in the perfusate of hippocampal slices and in purified rat hippocampa...