The Multiple Roles of B Cells in the Pathogenesis of Sjögren’s Syndrome

• Published in: Frontiers in immunology Vol. 12; p. 684999
• Main Authors: Du, Wenhan, Han, Man, Zhu, Xiaoxia, Xiao, Fan, Huang, Enyu, Che, Nan, Tang, Xiaopo, Zou, Hejian, Jiang, Quan, Lu, Liwei
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 08.06.2021
• Subjects: B cells; Immunology; pathogenesis; primary Sjögren’s syndrome; regulatory functions; treatment

Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease characterized by lymphocytic infiltration and tissue destruction of exocrine glands such as salivary glands. Although the formation of ectopic lymphoid tissue in exocrine glands and overproduction of autoantibodies by autoreactive B ce...