Neuronal Mitochondria Modulation of LPS-Induced Neuroinflammation

• Published in: The Journal of neuroscience Vol. 40; no. 8; pp. 1756 - 1765
• Main Authors: Harland, Micah, Torres, Sandy, Liu, Jingyi, Wang, Xinglong
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 19.02.2020
• Subjects: Activation; Chemokines; Fusion protein; IL-1β; Inflammation; Lethality; Lipopolysaccharides; Membrane fusion; Membrane proteins; Microglia; Mitochondria; Neurodegeneration; Neurodegenerative diseases; Neuromodulation; Neurons; Spleen; Transgenic mice; Tumor necrosis factor-α; Mfn2; neuroinflammation; LPS; sepsis; septic myocardial dysfunction; mitochondrial dynamics

Neuronal mitochondria dysfunction and neuroinflammation are two prominent pathological features increasingly realized as important pathogenic mechanisms for neurodegenerative diseases. However, little attempt has been taken to investigate the likely interactions between them. Mitofusin2 (Mfn2) is a...