Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance

• Published in: Nature communications Vol. 6; no. 1; p. 7090
• Main Authors: Swamy, Mahima, Abeler-Dörner, Lucie, Chettle, James, Mahlakõiv, Tanel, Goubau, Delphine, Chakravarty, Probir, Ramsay, George, Reis e Sousa, Caetano, Staeheli, Peter, Blacklaws, Barbara A., Heeney, Jonathan L., Hayday, Adrian C.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.05.2015; Nature Publishing Group; Nature Pub. Group
• Subjects: 13/106; 13/21; 13/51; 14/19; 38/61; 38/77; 631/250/127/1212; 631/250/1619/554; 631/250/347; 631/326/22/1434; 64/110; 64/60; 82/29; 96/1; 96/31; Animals; Antiviral drugs; Biology; Caliciviridae Infections - immunology; Cell activation; Cytokines; Cytokines - metabolism; Cytolysis; Cytotoxicity; Epithelial cells; Epithelial Cells - immunology; Epithelium; Female; Gastroenteritis - immunology; Gastroenteritis - virology; Gene expression; Genes; Humanities and Social Sciences; Immune system; Immunity, Innate; Infections; Interferon; Interferon-alpha - metabolism; Interferon-gamma - metabolism; Interferons - metabolism; Intestine; Intestine, Small - metabolism; Lymphocyte Activation; Lymphocytes; Lymphocytes - immunology; Lymphocytes T; Macrophages - cytology; Mice; Mice, Inbred C57BL; Mice, Knockout; multidisciplinary; Norovirus - immunology; Science; Science (multidisciplinary); T-Lymphocytes - immunology; Villus; Viruses

Unrelenting environmental challenges to the gut epithelium place particular demands on the local immune system. In this context, intestinal intraepithelial lymphocytes (IEL) compose a large, highly conserved T cell compartment, hypothesized to provide a first line of defence via cytolysis of dysregu...