Metabolic Flux Analysis of Plastidic Isoprenoid Biosynthesis in Poplar Leaves Emitting and Nonemitting Isoprene

The plastidic 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway is one of the most important pathways in plants and produces a large variety of essential isoprenoids. Its regulation, however, is still not well understood. Using the stable isotope ¹³C-labeling technique, we analyzed the carbon fluxes...

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Published inPlant physiology (Bethesda) Vol. 165; no. 1; pp. 37 - 51
Main Authors Ghirardo, Andrea, Wright, Louwrance Peter, Bi, Zhen, Rosenkranz, Maaria, Pulido, Pablo, Rodríguez-Concepción, Manuel, Niinemets, Ülo, Brüggemann, Nicolas, Gershenzon, Jonathan, Schnitzler, Jörg-Peter
Format Journal Article
LanguageEnglish
Published United States American Society of Plant Biologists 01.05.2014
Subjects
BIOCHEMISTRY AND METABOLISM
Biosynthesis
Butadienes
Carbon
Carbon - metabolism
Carbon Dioxide - metabolism
Carbon Isotopes
Down-Regulation - radiation effects
Erythritol - analogs & derivatives
Erythritol - metabolism
Hemiterpenes - biosynthesis
Hemiterpenes - metabolism
isoprene
Isotope Labeling
Leaves
Light
metabolic flux analysis
Metabolic Flux Analysis - methods
Metabolism
Models, Biological
Organophosphorus Compounds - metabolism
Pentanes
Pigments
Pigments, Biological - metabolism
Plant cells
Plant Leaves - metabolism
Plant Leaves - radiation effects
Plants
Plastids
Plastids - enzymology
Plastids - metabolism
Plastids - radiation effects
Pollutant emissions
Populus - metabolism
Populus - radiation effects
Sugar Phosphates - metabolism
Temperature
Terpenoids
Transferases - metabolism
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Abstract The plastidic 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway is one of the most important pathways in plants and produces a large variety of essential isoprenoids. Its regulation, however, is still not well understood. Using the stable isotope ¹³C-labeling technique, we analyzed the carbon fluxes through the pathway and into the major plastidic isoprenoid products in isoprene-emitting and transgenic isoprene-nonemitting (NE) gray poplar (Populus × canescens). We assessed the dependence on temperature, light intensity, and atmospheric [CO₂]. Isoprene biosynthesis was by far (99%) the main carbon sink of pathway intermediates in mature gray poplar leaves, and its production required severalfold higher carbon fluxes compared with NE leaves with almost zero isoprene emission. To compensate for the much lower demand for carbon, NE leaves drastically reduced the overall carbon flux within the MEP pathway. Feedback inhibition of 1-deoxy-Dxylulose-5-phosphate synthase activity by accumulated plastidic dimethylallyl diphosphate almost completely explained this reduction in carbon flux. Our data demonstrate that short-term biochemical feedback regulation of 1-deoxy-D-xylulose-5-phosphate synthase activity by plastidic dimethylallyl diphosphate is an important regulatory mechanism of the approximately 0.5% of this saved carbon toward essential nonvolatile isoprenoids, i.e. β-carotene and lutein, most probably to compensate for the absence of isoprene and its antioxidant properties.
AbstractList The plastidic 2-C-methyl-d-erythritol-4-phosphate (MEP) pathway is one of the most important pathways in plants and produces a large variety of essential isoprenoids. Its regulation, however, is still not well understood. Using the stable isotope 13C-labeling technique, we analyzed the carbon fluxes through the MEP pathway and into the major plastidic isoprenoid products in isoprene-emitting and transgenic isoprene-nonemitting (NE) gray poplar (Populus × canescens). We assessed the dependence on temperature, light intensity, and atmospheric [CO2]. Isoprene biosynthesis was by far (99%) the main carbon sink of MEP pathway intermediates in mature gray poplar leaves, and its production required severalfold higher carbon fluxes compared with NE leaves with almost zero isoprene emission. To compensate for the much lower demand for carbon, NE leaves drastically reduced the overall carbon flux within the MEP pathway. Feedback inhibition of 1-deoxy-d-xylulose-5-phosphate synthase activity by accumulated plastidic dimethylallyl diphosphate almost completely explained this reduction in carbon flux. Our data demonstrate that short-term biochemical feedback regulation of 1-deoxy-d-xylulose-5-phosphate synthase activity by plastidic dimethylallyl diphosphate is an important regulatory mechanism of the MEP pathway. Despite being relieved from the large carbon demand of isoprene biosynthesis, NE plants redirected only approximately 0.5% of this saved carbon toward essential nonvolatile isoprenoids, i.e. β-carotene and lutein, most probably to compensate for the absence of isoprene and its antioxidant properties.
Isoprene biosynthesis demands a huge carbon flux through the plastidic isoprenoid pathway, and the concentration of its immediate precursor modulates this flux .
The plastidic 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway is one of the most important pathways in plants and produces a large variety of essential isoprenoids. Its regulation, however, is still not well understood. Using the stable isotope 13C-labeling technique, we analyzed the carbon fluxes through the MEP pathway and into the major plastidic isoprenoid products in isoprene-emitting and transgenic isoprene-nonemitting (NE) gray poplar (Populus×canescens). We assessed the dependence on temperature, light intensity, and atmospheric [CO2]. Isoprene biosynthesis was by far (99%) the main carbon sink of MEP pathway intermediates in mature gray poplar leaves, and its production required severalfold higher carbon fluxes compared with NE leaves with almost zero isoprene emission. To compensate for the much lower demand for carbon, NE leaves drastically reduced the overall carbon flux within the MEP pathway. Feedback inhibition of 1-deoxy-D-xylulose-5-phosphate synthase activity by accumulated plastidic dimethylallyl diphosphate almost completely explained this reduction in carbon flux. Our data demonstrate that short-term biochemical feedback regulation of 1-deoxy-d-xylulose-5-phosphate synthase activity by plastidic dimethylallyl diphosphate is an important regulatory mechanism of the MEP pathway. Despite being relieved from the large carbon demand of isoprene biosynthesis, NE plants redirected only approximately 0.5% of this saved carbon toward essential nonvolatile isoprenoids, i.e. β-carotene and lutein, most probably to compensate for the absence of isoprene and its antioxidant properties.The plastidic 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway is one of the most important pathways in plants and produces a large variety of essential isoprenoids. Its regulation, however, is still not well understood. Using the stable isotope 13C-labeling technique, we analyzed the carbon fluxes through the MEP pathway and into the major plastidic isoprenoid products in isoprene-emitting and transgenic isoprene-nonemitting (NE) gray poplar (Populus×canescens). We assessed the dependence on temperature, light intensity, and atmospheric [CO2]. Isoprene biosynthesis was by far (99%) the main carbon sink of MEP pathway intermediates in mature gray poplar leaves, and its production required severalfold higher carbon fluxes compared with NE leaves with almost zero isoprene emission. To compensate for the much lower demand for carbon, NE leaves drastically reduced the overall carbon flux within the MEP pathway. Feedback inhibition of 1-deoxy-D-xylulose-5-phosphate synthase activity by accumulated plastidic dimethylallyl diphosphate almost completely explained this reduction in carbon flux. Our data demonstrate that short-term biochemical feedback regulation of 1-deoxy-d-xylulose-5-phosphate synthase activity by plastidic dimethylallyl diphosphate is an important regulatory mechanism of the MEP pathway. Despite being relieved from the large carbon demand of isoprene biosynthesis, NE plants redirected only approximately 0.5% of this saved carbon toward essential nonvolatile isoprenoids, i.e. β-carotene and lutein, most probably to compensate for the absence of isoprene and its antioxidant properties.
The plastidic 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway is one of the most important pathways in plants and produces a large variety of essential isoprenoids. Its regulation, however, is still not well understood. Using the stable isotope ¹³C-labeling technique, we analyzed the carbon fluxes through the pathway and into the major plastidic isoprenoid products in isoprene-emitting and transgenic isoprene-nonemitting (NE) gray poplar (Populus × canescens). We assessed the dependence on temperature, light intensity, and atmospheric [CO₂]. Isoprene biosynthesis was by far (99%) the main carbon sink of pathway intermediates in mature gray poplar leaves, and its production required severalfold higher carbon fluxes compared with NE leaves with almost zero isoprene emission. To compensate for the much lower demand for carbon, NE leaves drastically reduced the overall carbon flux within the MEP pathway. Feedback inhibition of 1-deoxy-Dxylulose-5-phosphate synthase activity by accumulated plastidic dimethylallyl diphosphate almost completely explained this reduction in carbon flux. Our data demonstrate that short-term biochemical feedback regulation of 1-deoxy-D-xylulose-5-phosphate synthase activity by plastidic dimethylallyl diphosphate is an important regulatory mechanism of the approximately 0.5% of this saved carbon toward essential nonvolatile isoprenoids, i.e. β-carotene and lutein, most probably to compensate for the absence of isoprene and its antioxidant properties.
Isoprene biosynthesis demands a huge carbon flux through the plastidic isoprenoid pathway, and the concentration of its immediate precursor modulates this flux . The plastidic 2-C-methyl- d -erythritol-4-phosphate ( MEP ) pathway is one of the most important pathways in plants and produces a large variety of essential isoprenoids. Its regulation, however, is still not well understood. Using the stable isotope 13 C-labeling technique, we analyzed the carbon fluxes through the MEP pathway and into the major plastidic isoprenoid products in isoprene-emitting and transgenic isoprene-nonemitting ( NE ) gray poplar ( Populus × canescens ). We assessed the dependence on temperature, light intensity, and atmospheric [CO 2 ]. Isoprene biosynthesis was by far (99%) the main carbon sink of MEP pathway intermediates in mature gray poplar leaves, and its production required severalfold higher carbon fluxes compared with NE leaves with almost zero isoprene emission. To compensate for the much lower demand for carbon, NE leaves drastically reduced the overall carbon flux within the MEP pathway. Feedback inhibition of 1-deoxy- d -xylulose-5-phosphate synthase activity by accumulated plastidic dimethylallyl diphosphate almost completely explained this reduction in carbon flux. Our data demonstrate that short-term biochemical feedback regulation of 1-deoxy- d -xylulose-5-phosphate synthase activity by plastidic dimethylallyl diphosphate is an important regulatory mechanism of the MEP pathway. Despite being relieved from the large carbon demand of isoprene biosynthesis, NE plants redirected only approximately 0.5% of this saved carbon toward essential nonvolatile isoprenoids, i.e. β-carotene and lutein, most probably to compensate for the absence of isoprene and its antioxidant properties.
The plastidic 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway is one of the most important pathways in plants and produces a large variety of essential isoprenoids. Its regulation, however, is still not well understood. Using the stable isotope 13C-labeling technique, we analyzed the carbon fluxes through the MEP pathway and into the major plastidic isoprenoid products in isoprene-emitting and transgenic isoprene-nonemitting (NE) gray poplar (Populus×canescens). We assessed the dependence on temperature, light intensity, and atmospheric [CO2]. Isoprene biosynthesis was by far (99%) the main carbon sink of MEP pathway intermediates in mature gray poplar leaves, and its production required severalfold higher carbon fluxes compared with NE leaves with almost zero isoprene emission. To compensate for the much lower demand for carbon, NE leaves drastically reduced the overall carbon flux within the MEP pathway. Feedback inhibition of 1-deoxy-D-xylulose-5-phosphate synthase activity by accumulated plastidic dimethylallyl diphosphate almost completely explained this reduction in carbon flux. Our data demonstrate that short-term biochemical feedback regulation of 1-deoxy-d-xylulose-5-phosphate synthase activity by plastidic dimethylallyl diphosphate is an important regulatory mechanism of the MEP pathway. Despite being relieved from the large carbon demand of isoprene biosynthesis, NE plants redirected only approximately 0.5% of this saved carbon toward essential nonvolatile isoprenoids, i.e. β-carotene and lutein, most probably to compensate for the absence of isoprene and its antioxidant properties.
Author Rodríguez-Concepción, Manuel
Gershenzon, Jonathan
Brüggemann, Nicolas
Rosenkranz, Maaria
Wright, Louwrance Peter
Niinemets, Ülo
Bi, Zhen
Schnitzler, Jörg-Peter
Ghirardo, Andrea
Pulido, Pablo
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  surname: Rosenkranz
  fullname: Rosenkranz, Maaria
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  surname: Pulido
  fullname: Pulido, Pablo
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  givenname: Manuel
  surname: Rodríguez-Concepción
  fullname: Rodríguez-Concepción, Manuel
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  fullname: Schnitzler, Jörg-Peter
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24590857$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1104/pp.106.092759
10.1111/j.1365-3040.2004.01250.x
10.1104/pp.103.037374
10.1093/mp/sss015
10.1046/j.1365-313x.2000.00764.x
10.1111/j.1365-3040.1993.tb00907.x
10.1371/journal.pone.0032387
10.1016/j.phytochem.2010.02.016
10.1146/annurev.arplant.52.1.407
10.1074/jbc.M302526200
10.1038/nature01312
10.1074/jbc.M208659200
10.1104/pp.102.012294
10.1126/science.1137786
10.1007/s11103-008-9441-2
10.1111/nph.12325
10.1111/nph.12200
10.1111/j.1365-3040.2004.01314.x
10.1073/pnas.0407360102
10.1016/j.tplants.2009.12.006
10.1111/nph.12477
10.1046/j.1365-3040.1999.00505.x
10.1029/2010GL046520
10.1111/j.1365-3040.2012.02584.x
10.1104/pp.108.133512
10.1111/j.1365-313X.2007.03157.x
10.1111/j.1365-3040.2007.01668.x
10.1104/pp.109.151647
10.1371/journal.pone.0017393
10.1016/j.tibtech.2007.12.003
10.5194/acp-12-1021-2012
10.1515/znc-1998-11-1208
10.1073/pnas.95.5.2100
10.1111/j.1467-7652.2004.00091.x
10.1073/pnas.1031755100
10.1104/pp.010497
10.1093/treephys/22.14.1011
10.1111/pce.12190
10.1104/pp.105.066373
10.1093/treephys/tpt018
10.1111/j.1365-3040.2011.02322.x
10.1074/jbc.M113.464636
10.1046/j.1469-8137.2002.00516.x
10.1038/nchembio836
10.1111/nph.12145
10.1021/ac052027c
10.1111/j.1438-8677.2008.00146.x
10.1104/pp.110.162081
10.1111/nph.12391
10.1021/jo061466o
10.1104/pp.104.039537
10.1074/jbc.M100854200
10.1007/s11120-010-9528-x
10.1093/aob/mcm240
10.1111/j.1469-8137.2011.03979.x
10.1105/tpc.104.028860
10.1038/nchembio.2007.5
10.1111/j.1469-8137.2012.04204.x
10.1111/j.1365-3040.2009.01980.x
10.1111/j.1365-2486.2012.02789.x
10.1093/treephys/tpp009
10.1023/A:1006300616544
10.1016/j.phytochem.2007.04.021
10.1046/j.1365-3040.2000.00536.x
10.1007/s11101-005-3130-4
10.1038/374769a0
10.1016/j.cell.2012.04.038
10.1111/j.1365-3040.2009.02104.x
10.1038/nchembio.158
10.1007/s00425-002-0825-2
10.1038/nbt1251
10.1111/j.1438-8677.2009.00284.x
10.1021/pr401124z
10.5194/acp-8-4605-2008
10.1093/jxb/ert318
10.1104/pp.104.043737
10.1175/1520-0477(2000)081<1537:BHITAB>2.3.CO;2
10.1104/pp.109.141978
10.1016/S0003-9861(03)00233-9
10.1111/j.1469-8137.2007.02094.x
10.1104/pp.106.086355
10.1016/j.ab.2012.11.031
10.1034/j.1399-3054.2002.1150203.x
10.1007/s11103-010-9654-z
10.1007/s00425-005-0022-1
10.1002/rcm.258
10.1016/j.ab.2013.05.028
10.1105/tpc.113.113001
10.1016/j.tplants.2010.02.003
10.1105/tpc.108.063248
10.1007/s00442-011-1947-7
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Copyright 2014 American Society of Plant Biologists
2014 American Society of Plant Biologists. All Rights Reserved. 2014
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The author responsible for distribution of materials integral to the findings presented in this article in accordance with the policy described in the Instructions for Authors (www.plantphysiol.org) is: Jörg-Peter Schnitzler (jp.schnitzler@helmholtz-muenchen.de).
www.plantphysiol.org/cgi/doi/10.1104/pp.114.236018
OpenAccessLink http://www.plantphysiol.org/content/plantphysiol/165/1/37.full.pdf
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  year: 2014
  text: 2014-05-01
  day: 01
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PublicationTitle Plant physiology (Bethesda)
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References Sharkey (2021052607425876700_b75) 2001; 52
Kreuzwieser (2021052607425876700_b41) 2002; 156
Beisel (2021052607425876700_b11) 2010; 152
Rasulov (2021052607425876700_b65) 2009; 151
Banerjee (2021052607425876700_b4) 2013; 288
Trowbridge (2021052607425876700_b80) 2012; 7
Arneth (2021052607425876700_b3) 2008; 8
Cinege (2021052607425876700_b18) 2009; 69
Wolfertz (2021052607425876700_b90) 2004; 135
Moses (2021052607425876700_b55) 2013; 200
Monson (2021052607425876700_b54) 2012; 195
Way (2021052607425876700_b86) 2011; 166
Cazzonelli (2021052607425876700_b16) 2010; 15
Chang (2021052607425876700_b17) 2006; 2
Dudareva (2021052607425876700_b21) 2005; 102
Estévez (2021052607425876700_b25) 2001; 276
2021052607425876700_b57
Rios-Estepa (2021052607425876700_b66) 2007; 68
Sharkey (2021052607425876700_b73) 1995; 374
Rasulov (2021052607425876700_b63) 2009; 149
Thulasiram (2021052607425876700_b79) 2007; 316
Behnke (2021052607425876700_b10) 2010; 104
Bick (2021052607425876700_b12) 2003; 415
Behnke (2021052607425876700_b9) 2009; 29
Gershenzon (2021052607425876700_b28) 2007; 3
Behnke (2021052607425876700_b5) 2007; 51
Ghirardo (2021052607425876700_b31) 2010; 71
Behnke (2021052607425876700_b6) 2013; 33
Dudareva (2021052607425876700_b22) 2013; 198
Hemmerlin (2021052607425876700_b35) 2003; 278
Vranová (2021052607425876700_b84) 2012; 5
Way (2021052607425876700_b85) 2013; 200
Werner (2021052607425876700_b88) 2001; 15
Coplen (2021052607425876700_b19) 2006; 78
Velikova (2021052607425876700_b82) 2005; 28
Sun (2021052607425876700_b78) 2013; 198
Zeidler (2021052607425876700_b93) 1997; 53
Laule (2021052607425876700_b43) 2003; 100
Loivamäki (2021052607425876700_b47) 2007; 143
Rasulov (2021052607425876700_b62) 2013; 37
Rosenstiel (2021052607425876700_b68) 2003; 421
Weise (2021052607425876700_b87) 2013; 435
Loreto (2021052607425876700_b51) 2001; 127
Pulido (2021052607425876700_b61) 2013; 25
Kasahara (2021052607425876700_b39) 2002; 277
Muñoz-Bertomeu (2021052607425876700_b56) 2006; 142
Archibald (2021052607425876700_b2) 2011; 38
Vickers (2021052607425876700_b83) 2009; 5
Ryan (2021052607425876700_b69) 2014; 201
Brüggemann (2021052607425876700_b14) 2002; 22
Affek (2021052607425876700_b1) 2003; 131
Loreto (2021052607425876700_b50) 2010; 15
Giuliano (2021052607425876700_b32) 2008; 26
Peñuelas (2021052607425876700_b59) 2005; 28
Ehlting (2021052607425876700_b23) 2007; 30
Illarionova (2021052607425876700_b36) 2006; 71
Xiao (2021052607425876700_b92) 2012; 149
Ivanova (2021052607425876700_b37) 2009; 11
Velikova (2021052607425876700_b81)
Niinemets (2021052607425876700_b58) 1999; 22
2021052607425876700_b33
Loreto (2021052607425876700_b49) 2004; 135
Gerber (2021052607425876700_b27) 2009; 21
Ghirardo (2021052607425876700_b30) 2010; 33
Karl (2021052607425876700_b38) 2002; 215
Schnitzler (2021052607425876700_b72) 2005; 222
Behnke (2021052607425876700_b7) 2012; 194
Behnke (2021052607425876700_b8) 2010; 74
Li (2021052607425876700_b45) 2013; 36
Schnitzler (2021052607425876700_b70) 2004; 135
Brüggemann (2021052607425876700_b15) 2002; 115
Brilli (2021052607425876700_b13) 2007; 175
Enfissi (2021052607425876700_b24) 2005; 3
Schnitzler (2021052607425876700_b71) 2010; 12
Sun (2021052607425876700_b76) 2013; 64
Delwiche (2021052607425876700_b20) 1993; 650
Lois (2021052607425876700_b46) 2000; 22
Guevara-García (2021052607425876700_b34) 2005; 17
Sharkey (2021052607425876700_b74) 2008; 101
Poisson (2021052607425876700_b60) 2000; 36
Fuentes (2021052607425876700_b26) 2000; 81
Ghirardo (2021052607425876700_b29) 2011; 6
Lange (2021052607425876700_b42) 1998; 95
Kiendler-Scharr (2021052607425876700_b40) 2012; 12
Rasulov (2021052607425876700_b64) 2010; 154
Zhou (2021052607425876700_b94) 2013; 440
2021052607425876700_b44
Kaling (2021052607425876700_b95) 2014
Wiberley (2021052607425876700_b89) 2009; 32
Sun (2021052607425876700_b77) 2012; 18
Mayrhofer (2021052607425876700_b52) 2005; 139
Mongélard (2021052607425876700_b53) 2011; 34
Loreto (2021052607425876700_b48) 2000; 23
Rodríguez-Concepción (2021052607425876700_b67) 2006; 5
Wu (2021052607425876700_b91) 2006; 24
References_xml – volume: 143
  start-page: 540
  year: 2007
  ident: 2021052607425876700_b47
  article-title: Circadian rhythms of isoprene biosynthesis in grey poplar leaves
  publication-title: Plant Physiol
  doi: 10.1104/pp.106.092759
– volume: 28
  start-page: 278
  year: 2005
  ident: 2021052607425876700_b59
  article-title: Linking isoprene with plant thermotolerance, antioxidants and monoterpene emissions
  publication-title: Plant Cell Environ
  doi: 10.1111/j.1365-3040.2004.01250.x
– volume: 135
  start-page: 152
  year: 2004
  ident: 2021052607425876700_b70
  article-title: Contribution of different carbon sources to isoprene biosynthesis in poplar leaves
  publication-title: Plant Physiol
  doi: 10.1104/pp.103.037374
– volume: 5
  start-page: 318
  year: 2012
  ident: 2021052607425876700_b84
  article-title: Structure and dynamics of the isoprenoid pathway network
  publication-title: Mol Plant
  doi: 10.1093/mp/sss015
– volume: 22
  start-page: 503
  year: 2000
  ident: 2021052607425876700_b46
  article-title: Carotenoid biosynthesis during tomato fruit development: regulatory role of 1-deoxy-d-xylulose 5-phosphate synthase
  publication-title: Plant J
  doi: 10.1046/j.1365-313x.2000.00764.x
– volume: 650
  start-page: 587
  year: 1993
  ident: 2021052607425876700_b20
  article-title: Rapid appearance of 13C in biogenic isoprene when 13CO2 is fed to intact leaves
  publication-title: Plant Cell Environ
  doi: 10.1111/j.1365-3040.1993.tb00907.x
– volume: 7
  start-page: e32387
  year: 2012
  ident: 2021052607425876700_b80
  article-title: Contribution of various carbon sources toward isoprene biosynthesis in poplar leaves mediated by altered atmospheric CO2 concentrations
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0032387
– volume: 71
  start-page: 918
  year: 2010
  ident: 2021052607425876700_b31
  article-title: Analysis of 1-deoxy-d-xylulose 5-phosphate synthase activity in grey poplar leaves using isotope ratio mass spectrometry
  publication-title: Phytochemistry
  doi: 10.1016/j.phytochem.2010.02.016
– volume: 52
  start-page: 407
  year: 2001
  ident: 2021052607425876700_b75
  article-title: Isoprene emission from plants
  publication-title: Annu Rev Plant Physiol Plant Mol Biol
  doi: 10.1146/annurev.arplant.52.1.407
– volume: 278
  start-page: 26666
  year: 2003
  ident: 2021052607425876700_b35
  article-title: Cross-talk between the cytosolic mevalonate and the plastidial methylerythritol phosphate pathways in tobacco bright yellow-2 cells
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M302526200
– volume: 421
  start-page: 256
  year: 2003
  ident: 2021052607425876700_b68
  article-title: Increased CO2 uncouples growth from isoprene emission in an agriforest ecosystem
  publication-title: Nature
  doi: 10.1038/nature01312
– volume: 277
  start-page: 45188
  year: 2002
  ident: 2021052607425876700_b39
  article-title: Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of gibberellins in Arabidopsis
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M208659200
– volume: 131
  start-page: 1727
  year: 2003
  ident: 2021052607425876700_b1
  article-title: Natural abundance carbon isotope composition of isoprene reflects incomplete coupling between isoprene synthesis and photosynthetic carbon flow
  publication-title: Plant Physiol
  doi: 10.1104/pp.102.012294
– volume: 316
  start-page: 73
  year: 2007
  ident: 2021052607425876700_b79
  article-title: Chimeras of two isoprenoid synthases catalyze all four coupling reactions in isoprenoid biosynthesis
  publication-title: Science
  doi: 10.1126/science.1137786
– volume: 69
  start-page: 593
  year: 2009
  ident: 2021052607425876700_b18
  article-title: Regulation of isoprene synthase promoter by environmental and internal factors
  publication-title: Plant Mol Biol
  doi: 10.1007/s11103-008-9441-2
– volume: 200
  start-page: 27
  year: 2013
  ident: 2021052607425876700_b55
  article-title: Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biology in vivo and in vitro
  publication-title: New Phytol
  doi: 10.1111/nph.12325
– volume: 198
  start-page: 788
  year: 2013
  ident: 2021052607425876700_b78
  article-title: Elevated atmospheric CO2 concentration leads to increased whole-plant isoprene emission in hybrid aspen (Populus tremula × Populus tremuloides)
  publication-title: New Phytol
  doi: 10.1111/nph.12200
– ident: 2021052607425876700_b33
– volume: 28
  start-page: 318
  year: 2005
  ident: 2021052607425876700_b82
  article-title: On the relationship between isoprene emission and thermotolerance in Phragmites australis leaves exposed to high temperatures and during the recovery from a heat stress
  publication-title: Plant Cell Environ
  doi: 10.1111/j.1365-3040.2004.01314.x
– volume: 102
  start-page: 933
  year: 2005
  ident: 2021052607425876700_b21
  article-title: The nonmevalonate pathway supports both monoterpene and sesquiterpene formation in snapdragon flowers
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0407360102
– volume: 15
  start-page: 154
  year: 2010
  ident: 2021052607425876700_b50
  article-title: Abiotic stresses and induced BVOCs
  publication-title: Trends Plant Sci
  doi: 10.1016/j.tplants.2009.12.006
– volume: 201
  start-page: 205
  year: 2014
  ident: 2021052607425876700_b69
  article-title: Isoprene emission protects photosynthesis but reduces plant productivity during drought in transgenic tobacco (Nicotiana tabacum) plants
  publication-title: New Phytol
  doi: 10.1111/nph.12477
– volume: 22
  start-page: 1319
  year: 1999
  ident: 2021052607425876700_b58
  article-title: A model of isoprene emission based on energetic requirements for isoprene synthesis and leaf photosynthetic properties for Liquidambar and Quercus
  publication-title: Plant Cell Environ
  doi: 10.1046/j.1365-3040.1999.00505.x
– volume: 38
  year: 2011
  ident: 2021052607425876700_b2
  article-title: Impacts of HOx regeneration and recycling in the oxidation of isoprene: consequences for the composition of past, present and future atmospheres
  publication-title: Geophys Res Lett
  doi: 10.1029/2010GL046520
– volume: 36
  start-page: 429
  year: 2013
  ident: 2021052607425876700_b45
  article-title: Metabolic profiling of the methylerythritol phosphate pathway reveals the source of post-illumination isoprene burst from leaves
  publication-title: Plant Cell Environ
  doi: 10.1111/j.1365-3040.2012.02584.x
– volume: 149
  start-page: 1609
  year: 2009
  ident: 2021052607425876700_b63
  article-title: Postillumination isoprene emission: in vivo measurements of dimethylallyldiphosphate pool size and isoprene synthase kinetics in aspen leaves
  publication-title: Plant Physiol
  doi: 10.1104/pp.108.133512
– volume: 51
  start-page: 485
  year: 2007
  ident: 2021052607425876700_b5
  article-title: Transgenic, non-isoprene emitting poplars don’t like it hot
  publication-title: Plant J
  doi: 10.1111/j.1365-313X.2007.03157.x
– volume: 30
  start-page: 796
  year: 2007
  ident: 2021052607425876700_b23
  article-title: Interaction of nitrogen nutrition and salinity in grey poplar (Populus tremula × alba)
  publication-title: Plant Cell Environ
  doi: 10.1111/j.1365-3040.2007.01668.x
– volume: 152
  start-page: 2188
  year: 2010
  ident: 2021052607425876700_b11
  article-title: Continuous turnover of carotenes and chlorophyll a in mature leaves of Arabidopsis revealed by 14CO2 pulse-chase labeling
  publication-title: Plant Physiol
  doi: 10.1104/pp.109.151647
– volume: 6
  start-page: e17393
  year: 2011
  ident: 2021052607425876700_b29
  article-title: Biogenic volatile organic compound and respiratory CO2 emissions after 13C-labeling: online tracing of C translocation dynamics in poplar plants
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0017393
– volume: 26
  start-page: 139
  year: 2008
  ident: 2021052607425876700_b32
  article-title: Metabolic engineering of carotenoid biosynthesis in plants
  publication-title: Trends Biotechnol
  doi: 10.1016/j.tibtech.2007.12.003
– volume: 12
  start-page: 1021
  year: 2012
  ident: 2021052607425876700_b40
  article-title: Isoprene in poplar emissions: effects on new particle formation and OH concentrations
  publication-title: Atmos Chem Phys
  doi: 10.5194/acp-12-1021-2012
– volume: 53
  start-page: 980
  year: 1997
  ident: 2021052607425876700_b93
  article-title: Is isoprene emitted by plants synthesized via the novel isopentenyl pyrophosphate pathway?
  publication-title: Z Naturforsch C
  doi: 10.1515/znc-1998-11-1208
– volume: 95
  start-page: 2100
  year: 1998
  ident: 2021052607425876700_b42
  article-title: A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.95.5.2100
– volume: 3
  start-page: 17
  year: 2005
  ident: 2021052607425876700_b24
  article-title: Metabolic engineering of the mevalonate and non-mevalonate isopentenyl diphosphate-forming pathways for the production of health-promoting isoprenoids in tomato
  publication-title: Plant Biotechnol J
  doi: 10.1111/j.1467-7652.2004.00091.x
– volume: 100
  start-page: 6866
  year: 2003
  ident: 2021052607425876700_b43
  article-title: Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1031755100
– volume: 127
  start-page: 1781
  year: 2001
  ident: 2021052607425876700_b51
  article-title: Isoprene produced by leaves protects the photosynthetic apparatus against ozone damage, quenches ozone products, and reduces lipid peroxidation of cellular membranes
  publication-title: Plant Physiol
  doi: 10.1104/pp.010497
– volume: 22
  start-page: 1011
  year: 2002
  ident: 2021052607425876700_b14
  article-title: Relationship of isopentenyl diphosphate (IDP) isomerase activity to isoprene emission of oak leaves
  publication-title: Tree Physiol
  doi: 10.1093/treephys/22.14.1011
– volume: 37
  start-page: 724
  year: 2013
  ident: 2021052607425876700_b62
  article-title: Competition between isoprene emission and pigments synthesis during leaf development in aspen
  publication-title: Plant Cell Environ
  doi: 10.1111/pce.12190
– volume: 139
  start-page: 474
  year: 2005
  ident: 2021052607425876700_b52
  article-title: Diurnal and seasonal variation of isoprene biosynthesis-related genes in grey poplar leaves
  publication-title: Plant Physiol
  doi: 10.1104/pp.105.066373
– volume: 33
  start-page: 562
  year: 2013
  ident: 2021052607425876700_b6
  article-title: Isoprene function in two contrasting poplars under salt and sunflecks
  publication-title: Tree Physiol
  doi: 10.1093/treephys/tpt018
– volume: 34
  start-page: 1241
  year: 2011
  ident: 2021052607425876700_b53
  article-title: Measurement of carbon flux through the MEP pathway for isoprenoid synthesis by 31P-NMR spectroscopy after specific inhibition of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate reductase: effect of light and temperature
  publication-title: Plant Cell Environ
  doi: 10.1111/j.1365-3040.2011.02322.x
– volume: 288
  start-page: 16926
  year: 2013
  ident: 2021052607425876700_b4
  article-title: Feedback inhibition of deoxy-d-xylulose-5-phosphate synthase regulates the methylerythritol 4-phosphate pathway
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M113.464636
– volume: 156
  start-page: 171
  year: 2002
  ident: 2021052607425876700_b41
  article-title: Xylem-transported glucose as an additional carbon source for leaf isoprene formation in Quercus robur
  publication-title: New Phytol
  doi: 10.1046/j.1469-8137.2002.00516.x
– volume: 2
  start-page: 674
  year: 2006
  ident: 2021052607425876700_b17
  article-title: Production of isoprenoid pharmaceuticals by engineered microbes
  publication-title: Nat Chem Biol
  doi: 10.1038/nchembio836
– ident: 2021052607425876700_b57
– volume: 198
  start-page: 16
  year: 2013
  ident: 2021052607425876700_b22
  article-title: Biosynthesis, function and metabolic engineering of plant volatile organic compounds
  publication-title: New Phytol
  doi: 10.1111/nph.12145
– volume: 78
  start-page: 2439
  year: 2006
  ident: 2021052607425876700_b19
  article-title: New guidelines for δ13C measurements
  publication-title: Anal Chem
  doi: 10.1021/ac052027c
– volume: 11
  start-page: 625
  year: 2009
  ident: 2021052607425876700_b37
  article-title: Chloroplast parameters differ in wild type and transgenic poplars overexpressing gsh1 in the cytosol
  publication-title: Plant Biol (Stuttg)
  doi: 10.1111/j.1438-8677.2008.00146.x
– volume: 154
  start-page: 1558
  year: 2010
  ident: 2021052607425876700_b64
  article-title: Temperature response of isoprene emission in vivo reflects a combined effect of substrate limitations and isoprene synthase activity: a kinetic analysis
  publication-title: Plant Physiol
  doi: 10.1104/pp.110.162081
– volume: 200
  start-page: 534
  year: 2013
  ident: 2021052607425876700_b85
  article-title: Increasing atmospheric CO2 reduces metabolic and physiological differences between isoprene- and non-isoprene-emitting poplars
  publication-title: New Phytol
  doi: 10.1111/nph.12391
– volume: 71
  start-page: 8824
  year: 2006
  ident: 2021052607425876700_b36
  article-title: Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods
  publication-title: J Org Chem
  doi: 10.1021/jo061466o
– volume: 135
  start-page: 1903
  year: 2004
  ident: 2021052607425876700_b49
  article-title: 13C labeling reveals chloroplastic and extrachloroplastic pools of dimethylallyl pyrophosphate and their contribution to isoprene formation
  publication-title: Plant Physiol
  doi: 10.1104/pp.104.039537
– volume: 276
  start-page: 22901
  year: 2001
  ident: 2021052607425876700_b25
  article-title: 1-Deoxy-d-xylulose-5-phosphate synthase, a limiting enzyme for plastidic isoprenoid biosynthesis in plants
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M100854200
– volume: 104
  start-page: 5
  year: 2010
  ident: 2021052607425876700_b10
  article-title: Isoprene emission protects photosynthesis in sunfleck exposed grey poplar
  publication-title: Photosynth Res
  doi: 10.1007/s11120-010-9528-x
– ident: 2021052607425876700_b44
– volume: 101
  start-page: 5
  year: 2008
  ident: 2021052607425876700_b74
  article-title: Isoprene emission from plants: why and how
  publication-title: Ann Bot (Lond)
  doi: 10.1093/aob/mcm240
– volume: 194
  start-page: 70
  year: 2012
  ident: 2021052607425876700_b7
  article-title: Isoprene emission-free poplars: a chance to reduce the impact from poplar plantations on the atmosphere
  publication-title: New Phytol
  doi: 10.1111/j.1469-8137.2011.03979.x
– volume: 17
  start-page: 628
  year: 2005
  ident: 2021052607425876700_b34
  article-title: Characterization of the Arabidopsis clb6 mutant illustrates the importance of posttranscriptional regulation of the methyl-d-erythritol 4-phosphate pathway
  publication-title: Plant Cell
  doi: 10.1105/tpc.104.028860
– volume: 3
  start-page: 408
  year: 2007
  ident: 2021052607425876700_b28
  article-title: The function of terpene natural products in the natural world
  publication-title: Nat Chem Biol
  doi: 10.1038/nchembio.2007.5
– volume: 195
  start-page: 541
  year: 2012
  ident: 2021052607425876700_b54
  article-title: Modeling the isoprene emission rate from leaves
  publication-title: New Phytol
  doi: 10.1111/j.1469-8137.2012.04204.x
– volume: 32
  start-page: 939
  year: 2009
  ident: 2021052607425876700_b89
  article-title: Regulation of isoprene emission from poplar leaves throughout a day
  publication-title: Plant Cell Environ
  doi: 10.1111/j.1365-3040.2009.01980.x
– volume: 18
  start-page: 3423
  year: 2012
  ident: 2021052607425876700_b77
  article-title: Enhanced isoprene emission capacity and altered light responsiveness in aspen grown under elevated atmospheric CO2 concentration
  publication-title: Glob Change Biol
  doi: 10.1111/j.1365-2486.2012.02789.x
– volume: 29
  start-page: 725
  year: 2009
  ident: 2021052607425876700_b9
  article-title: RNAi-mediated suppression of isoprene biosynthesis in hybrid poplar impacts ozone tolerance
  publication-title: Tree Physiol
  doi: 10.1093/treephys/tpp009
– volume: 36
  start-page: 157
  year: 2000
  ident: 2021052607425876700_b60
  article-title: Impact of non-methane hydrocarbons on tropospheric chemistry and the oxidizing power of the global troposphere: 3-dimensional modelling results
  publication-title: J Atmos Chem
  doi: 10.1023/A:1006300616544
– volume: 68
  start-page: 2351
  year: 2007
  ident: 2021052607425876700_b66
  article-title: Experimental and mathematical approaches to modeling plant metabolic networks
  publication-title: Phytochemistry
  doi: 10.1016/j.phytochem.2007.04.021
– year: 2014
  ident: 2021052607425876700_b95
  article-title: UV-SI: UV-B mediated metabolic rearrangements in poplar revealed by non-targeted metabolomics
  publication-title: Plant Cell Environ
– volume: 23
  start-page: 229
  year: 2000
  ident: 2021052607425876700_b48
  article-title: Incomplete 13C labelling of α-pinene content of Quercus ilex leaves and appearance of unlabelled C in α-pinene emission in the dark
  publication-title: Plant Cell Environ
  doi: 10.1046/j.1365-3040.2000.00536.x
– volume: 5
  start-page: 1
  year: 2006
  ident: 2021052607425876700_b67
  article-title: Early steps in isoprenoid biosynthesis: multilevel regulation of the supply of common precursors in plant cells
  publication-title: Phytochem Rev
  doi: 10.1007/s11101-005-3130-4
– volume: 374
  start-page: 769
  year: 1995
  ident: 2021052607425876700_b73
  article-title: Why plants emits isoprene
  publication-title: Nature
  doi: 10.1038/374769a0
– volume: 149
  start-page: 1525
  year: 2012
  ident: 2021052607425876700_b92
  article-title: Retrograde signaling by the plastidial metabolite MEcPP regulates expression of nuclear stress-response genes
  publication-title: Cell
  doi: 10.1016/j.cell.2012.04.038
– volume: 33
  start-page: 781
  year: 2010
  ident: 2021052607425876700_b30
  article-title: Determination of de novo and pool emissions of terpenes from four common boreal/alpine trees by 13CO2 labelling and PTR-MS analysis
  publication-title: Plant Cell Environ
  doi: 10.1111/j.1365-3040.2009.02104.x
– volume: 5
  start-page: 283
  year: 2009
  ident: 2021052607425876700_b83
  article-title: A unified mechanism of action for volatile isoprenoids in plant abiotic stress
  publication-title: Nat Chem Biol
  doi: 10.1038/nchembio.158
– volume: 215
  start-page: 894
  year: 2002
  ident: 2021052607425876700_b38
  article-title: On-line analysis of the 13CO2 labeling of leaf isoprene suggests multiple subcellular origins of isoprene precursors
  publication-title: Planta
  doi: 10.1007/s00425-002-0825-2
– volume: 24
  start-page: 1441
  year: 2006
  ident: 2021052607425876700_b91
  article-title: Redirection of cytosolic or plastidic isoprenoid precursors elevates terpene production in plants
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt1251
– volume: 12
  start-page: 302
  year: 2010
  ident: 2021052607425876700_b71
  article-title: Poplar volatiles: biosynthesis, regulation and (eco)physiology of isoprene and stress-induced isoprenoids
  publication-title: Plant Biol (Stuttg)
  doi: 10.1111/j.1438-8677.2009.00284.x
– volume-title: J Proteome Res
  ident: 2021052607425876700_b81
  article-title: The genetic manipulation of isoprene emissions in poplar plants remodels the chloroplast proteome
  doi: 10.1021/pr401124z
– volume: 8
  start-page: 4605
  year: 2008
  ident: 2021052607425876700_b3
  article-title: Why are estimates of global terrestrial isoprene emissions so similar (and why is this not so for monoterpenes)?
  publication-title: Atmos Chem Phys
  doi: 10.5194/acp-8-4605-2008
– volume: 64
  start-page: 5509
  year: 2013
  ident: 2021052607425876700_b76
  article-title: Elevated [CO2] magnifies isoprene emissions under heat and improves thermal resistance in hybrid aspen
  publication-title: J Exp Bot
  doi: 10.1093/jxb/ert318
– volume: 135
  start-page: 1939
  year: 2004
  ident: 2021052607425876700_b90
  article-title: Rapid regulation of the methylerythritol 4-phosphate pathway during isoprene synthesis
  publication-title: Plant Physiol
  doi: 10.1104/pp.104.043737
– volume: 81
  start-page: 1537
  year: 2000
  ident: 2021052607425876700_b26
  article-title: Biogenic hydrocarbons in the atmospheric boundary layer: a review
  publication-title: Bull Am Meteorol Soc
  doi: 10.1175/1520-0477(2000)081<1537:BHITAB>2.3.CO;2
– volume: 151
  start-page: 448
  year: 2009
  ident: 2021052607425876700_b65
  article-title: Evidence that light, carbon dioxide, and oxygen dependencies of leaf isoprene emission are driven by energy status in hybrid aspen
  publication-title: Plant Physiol
  doi: 10.1104/pp.109.141978
– volume: 415
  start-page: 146
  year: 2003
  ident: 2021052607425876700_b12
  article-title: Metabolic cross talk between cytosolic and plastidial pathways of isoprenoid biosynthesis: unidirectional transport of intermediates across the chloroplast envelope membrane
  publication-title: Arch Biochem Biophys
  doi: 10.1016/S0003-9861(03)00233-9
– volume: 175
  start-page: 244
  year: 2007
  ident: 2021052607425876700_b13
  article-title: Response of isoprene emission and carbon metabolism to drought in white poplar (Populus alba) saplings
  publication-title: New Phytol
  doi: 10.1111/j.1469-8137.2007.02094.x
– volume: 142
  start-page: 890
  year: 2006
  ident: 2021052607425876700_b56
  article-title: Up-regulation of 1-deoxy-d-xylulose-5-phosphate synthase enhances production of essential oils in transgenic spike lavender
  publication-title: Plant Physiol
  doi: 10.1104/pp.106.086355
– volume: 435
  start-page: 27
  year: 2013
  ident: 2021052607425876700_b87
  article-title: Measuring dimethylallyl diphosphate available for isoprene synthesis
  publication-title: Anal Biochem
  doi: 10.1016/j.ab.2012.11.031
– volume: 115
  start-page: 190
  year: 2002
  ident: 2021052607425876700_b15
  article-title: Diurnal variation of dimethylallyl diphosphate concentrations in oak (Quercus robur) leaves
  publication-title: Physiol Plant
  doi: 10.1034/j.1399-3054.2002.1150203.x
– volume: 74
  start-page: 61
  year: 2010
  ident: 2021052607425876700_b8
  article-title: RNAi-mediated suppression of isoprene emission in poplar transiently impacts phenolic metabolism under high temperature and high light intensities: a transcriptomic and metabolomic analysis
  publication-title: Plant Mol Biol
  doi: 10.1007/s11103-010-9654-z
– volume: 222
  start-page: 777
  year: 2005
  ident: 2021052607425876700_b72
  article-title: Biochemical properties of isoprene synthase in poplar (Populus × canescens)
  publication-title: Planta
  doi: 10.1007/s00425-005-0022-1
– volume: 15
  start-page: 501
  year: 2001
  ident: 2021052607425876700_b88
  article-title: Referencing strategies and techniques in stable isotope ratio analysis
  publication-title: Rapid Commun Mass Spectrom
  doi: 10.1002/rcm.258
– volume: 440
  start-page: 130
  year: 2013
  ident: 2021052607425876700_b94
  article-title: Isopentenyl diphosphate and dimethylallyl diphosphate/isopentenyl diphosphate ratio measured with recombinant isopentenyl diphosphate isomerase and isoprene synthase
  publication-title: Anal Biochem
  doi: 10.1016/j.ab.2013.05.028
– volume: 25
  start-page: 4183
  year: 2013
  ident: 2021052607425876700_b61
  article-title: Arabidopsis J-protein J20 delivers the first enzyme of the plastidial isoprenoid pathway to protein quality control
  publication-title: Plant Cell
  doi: 10.1105/tpc.113.113001
– volume: 15
  start-page: 266
  year: 2010
  ident: 2021052607425876700_b16
  article-title: Source to sink: regulation of carotenoid biosynthesis in plants
  publication-title: Trends Plant Sci
  doi: 10.1016/j.tplants.2010.02.003
– volume: 21
  start-page: 285
  year: 2009
  ident: 2021052607425876700_b27
  article-title: The plastidial 2-C-methyl-d-erythritol 4-phosphate pathway provides the isoprenyl moiety for protein geranylgeranylation in tobacco BY-2 cells
  publication-title: Plant Cell
  doi: 10.1105/tpc.108.063248
– volume: 166
  start-page: 273
  year: 2011
  ident: 2021052607425876700_b86
  article-title: Enhanced isoprene-related tolerance of heat- and light-stressed photosynthesis at low, but not high, CO2 concentrations
  publication-title: Oecologia
  doi: 10.1007/s00442-011-1947-7
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Snippet The plastidic 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway is one of the most important pathways in plants and produces a large variety of essential...
The plastidic 2-C-methyl-d-erythritol-4-phosphate (MEP) pathway is one of the most important pathways in plants and produces a large variety of essential...
Isoprene biosynthesis demands a huge carbon flux through the plastidic isoprenoid pathway, and the concentration of its immediate precursor modulates this flux...
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SubjectTerms BIOCHEMISTRY AND METABOLISM
Biosynthesis
Butadienes
Carbon
Carbon - metabolism
Carbon Dioxide - metabolism
Carbon Isotopes
Down-Regulation - radiation effects
Erythritol - analogs & derivatives
Erythritol - metabolism
Hemiterpenes - biosynthesis
Hemiterpenes - metabolism
isoprene
Isotope Labeling
Leaves
Light
metabolic flux analysis
Metabolic Flux Analysis - methods
Metabolism
Models, Biological
Organophosphorus Compounds - metabolism
Pentanes
Pigments
Pigments, Biological - metabolism
Plant cells
Plant Leaves - metabolism
Plant Leaves - radiation effects
Plants
Plastids
Plastids - enzymology
Plastids - metabolism
Plastids - radiation effects
Pollutant emissions
Populus - metabolism
Populus - radiation effects
Sugar Phosphates - metabolism
Temperature
Terpenoids
Transferases - metabolism
Title Metabolic Flux Analysis of Plastidic Isoprenoid Biosynthesis in Poplar Leaves Emitting and Nonemitting Isoprene
URI https://www.jstor.org/stable/43190934
https://www.ncbi.nlm.nih.gov/pubmed/24590857
https://www.proquest.com/docview/1521911204
https://www.proquest.com/docview/2000109030
https://pubmed.ncbi.nlm.nih.gov/PMC4012595
Volume 165
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