Role of the 5-HT2A Receptor in Acute Effects of LSD on Empathy and Circulating Oxytocin
The psychedelic lysergic acid diethylamide (LSD) has experienced a revival in research, including clinical trials that evaluate LSD-assisted psychotherapy. LSD induces perceptual alterations and influences emotion processing in ways that may support psychotherapy. Here, we investigated the effects o...
Saved in:
| Published in | Frontiers in pharmacology Vol. 12; p. 711255 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Frontiers Media S.A
13.07.2021
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1663-9812 1663-9812 |
| DOI | 10.3389/fphar.2021.711255 |
Cover
Loading…
| Abstract | The psychedelic lysergic acid diethylamide (LSD) has experienced a revival in research, including clinical trials that evaluate LSD-assisted psychotherapy. LSD induces perceptual alterations and influences emotion processing in ways that may support psychotherapy. Here, we investigated the effects of LSD on emotional empathy and mediating role of the serotonin 5-hydroxytryptamine-2A (5-HT
2A
) receptor by administering 25, 50, 100, and 200 µg LSD alone and 200 µg LSD combined with pretreatment with the 5-HT
2A
receptor antagonist ketanserin (40 mg) using a placebo-controlled, double-blind, random-order, crossover design in 16 healthy subjects. The Multifaceted Empathy Test (MET) was used to assess the effects of LSD on emotional empathy. Plasma oxytocin levels were also measured. LSD dose-dependently increased implicit and explicit emotional empathy, with the highest 200 µg LSD dose having a significant effect compared with placebo. The 200 µg dose of LSD also moderately increased plasma oxytocin levels compared with placebo. Ketanserin reduced the LSD-induced elevations of oxytocin but not the LSD-induced increases in emotional empathy. These findings confirm that LSD enhances empathy, and this effect may be partially independent of its primary action on 5-HT
2A
receptors to induce subjective psychedelic effects. In contrast, LSD-induced oxytocin release may depend on 5-HT
2A
receptor stimulation, which is consistent with the psychedelic effect of LSD. Further studies are needed to investigate whether LSD may also enhance empathy and potentially produce therapeutic effects in patients who have deficits in empathy and impairments in social functioning. |
|---|---|
| AbstractList | The psychedelic lysergic acid diethylamide (LSD) has experienced a revival in research, including clinical trials that evaluate LSD-assisted psychotherapy. LSD induces perceptual alterations and influences emotion processing in ways that may support psychotherapy. Here, we investigated the effects of LSD on emotional empathy and mediating role of the serotonin 5-hydroxytryptamine-2A (5-HT2A) receptor by administering 25, 50, 100, and 200 µg LSD alone and 200 µg LSD combined with pretreatment with the 5-HT2A receptor antagonist ketanserin (40 mg) using a placebo-controlled, double-blind, random-order, crossover design in 16 healthy subjects. The Multifaceted Empathy Test (MET) was used to assess the effects of LSD on emotional empathy. Plasma oxytocin levels were also measured. LSD dose-dependently increased implicit and explicit emotional empathy, with the highest 200 µg LSD dose having a significant effect compared with placebo. The 200 µg dose of LSD also moderately increased plasma oxytocin levels compared with placebo. Ketanserin reduced the LSD-induced elevations of oxytocin but not the LSD-induced increases in emotional empathy. These findings confirm that LSD enhances empathy, and this effect may be partially independent of its primary action on 5-HT2A receptors to induce subjective psychedelic effects. In contrast, LSD-induced oxytocin release may depend on 5-HT2A receptor stimulation, which is consistent with the psychedelic effect of LSD. Further studies are needed to investigate whether LSD may also enhance empathy and potentially produce therapeutic effects in patients who have deficits in empathy and impairments in social functioning. The psychedelic lysergic acid diethylamide (LSD) has experienced a revival in research, including clinical trials that evaluate LSD-assisted psychotherapy. LSD induces perceptual alterations and influences emotion processing in ways that may support psychotherapy. Here, we investigated the effects of LSD on emotional empathy and mediating role of the serotonin 5-hydroxytryptamine-2A (5-HT 2A ) receptor by administering 25, 50, 100, and 200 µg LSD alone and 200 µg LSD combined with pretreatment with the 5-HT 2A receptor antagonist ketanserin (40 mg) using a placebo-controlled, double-blind, random-order, crossover design in 16 healthy subjects. The Multifaceted Empathy Test (MET) was used to assess the effects of LSD on emotional empathy. Plasma oxytocin levels were also measured. LSD dose-dependently increased implicit and explicit emotional empathy, with the highest 200 µg LSD dose having a significant effect compared with placebo. The 200 µg dose of LSD also moderately increased plasma oxytocin levels compared with placebo. Ketanserin reduced the LSD-induced elevations of oxytocin but not the LSD-induced increases in emotional empathy. These findings confirm that LSD enhances empathy, and this effect may be partially independent of its primary action on 5-HT 2A receptors to induce subjective psychedelic effects. In contrast, LSD-induced oxytocin release may depend on 5-HT 2A receptor stimulation, which is consistent with the psychedelic effect of LSD. Further studies are needed to investigate whether LSD may also enhance empathy and potentially produce therapeutic effects in patients who have deficits in empathy and impairments in social functioning. The psychedelic lysergic acid diethylamide (LSD) has experienced a revival in research, including clinical trials that evaluate LSD-assisted psychotherapy. LSD induces perceptual alterations and influences emotion processing in ways that may support psychotherapy. Here, we investigated the effects of LSD on emotional empathy and mediating role of the serotonin 5-hydroxytryptamine-2A (5-HT2A) receptor by administering 25, 50, 100, and 200 µg LSD alone and 200 µg LSD combined with pretreatment with the 5-HT2A receptor antagonist ketanserin (40 mg) using a placebo-controlled, double-blind, random-order, crossover design in 16 healthy subjects. The Multifaceted Empathy Test (MET) was used to assess the effects of LSD on emotional empathy. Plasma oxytocin levels were also measured. LSD dose-dependently increased implicit and explicit emotional empathy, with the highest 200 µg LSD dose having a significant effect compared with placebo. The 200 µg dose of LSD also moderately increased plasma oxytocin levels compared with placebo. Ketanserin reduced the LSD-induced elevations of oxytocin but not the LSD-induced increases in emotional empathy. These findings confirm that LSD enhances empathy, and this effect may be partially independent of its primary action on 5-HT2A receptors to induce subjective psychedelic effects. In contrast, LSD-induced oxytocin release may depend on 5-HT2A receptor stimulation, which is consistent with the psychedelic effect of LSD. Further studies are needed to investigate whether LSD may also enhance empathy and potentially produce therapeutic effects in patients who have deficits in empathy and impairments in social functioning.The psychedelic lysergic acid diethylamide (LSD) has experienced a revival in research, including clinical trials that evaluate LSD-assisted psychotherapy. LSD induces perceptual alterations and influences emotion processing in ways that may support psychotherapy. Here, we investigated the effects of LSD on emotional empathy and mediating role of the serotonin 5-hydroxytryptamine-2A (5-HT2A) receptor by administering 25, 50, 100, and 200 µg LSD alone and 200 µg LSD combined with pretreatment with the 5-HT2A receptor antagonist ketanserin (40 mg) using a placebo-controlled, double-blind, random-order, crossover design in 16 healthy subjects. The Multifaceted Empathy Test (MET) was used to assess the effects of LSD on emotional empathy. Plasma oxytocin levels were also measured. LSD dose-dependently increased implicit and explicit emotional empathy, with the highest 200 µg LSD dose having a significant effect compared with placebo. The 200 µg dose of LSD also moderately increased plasma oxytocin levels compared with placebo. Ketanserin reduced the LSD-induced elevations of oxytocin but not the LSD-induced increases in emotional empathy. These findings confirm that LSD enhances empathy, and this effect may be partially independent of its primary action on 5-HT2A receptors to induce subjective psychedelic effects. In contrast, LSD-induced oxytocin release may depend on 5-HT2A receptor stimulation, which is consistent with the psychedelic effect of LSD. Further studies are needed to investigate whether LSD may also enhance empathy and potentially produce therapeutic effects in patients who have deficits in empathy and impairments in social functioning. |
| Author | Varghese, Nimmy Liechti, Matthias E. Eckert, Anne Avedisian, Isidora Holze, Friederike |
| AuthorAffiliation | 3 Psychiatric University Hospital, University of Basel, Basel , Switzerland 1 Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel and University of Basel, Basel , Switzerland 2 Department of Pharmaceutical Sciences, University of Basel, Basel , Switzerland 4 Transfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, Basel , Switzerland |
| AuthorAffiliation_xml | – name: 4 Transfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, Basel , Switzerland – name: 1 Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel and University of Basel, Basel , Switzerland – name: 3 Psychiatric University Hospital, University of Basel, Basel , Switzerland – name: 2 Department of Pharmaceutical Sciences, University of Basel, Basel , Switzerland |
| Author_xml | – sequence: 1 givenname: Friederike surname: Holze fullname: Holze, Friederike – sequence: 2 givenname: Isidora surname: Avedisian fullname: Avedisian, Isidora – sequence: 3 givenname: Nimmy surname: Varghese fullname: Varghese, Nimmy – sequence: 4 givenname: Anne surname: Eckert fullname: Eckert, Anne – sequence: 5 givenname: Matthias E. surname: Liechti fullname: Liechti, Matthias E. |
| BookMark | eNp1kUFr2zAYhsXoWLuuP2A3HXdJpk-yJfsyCFm2FgKFrmNHIcufEhVH8mS5LP9-dtPBOpguEtL7PnzoeUvOQgxIyHtgSyGq-qPr9yYtOeOwVAC8LF-RC5BSLOoK-Nlf53NyNQwPbFqiroUs3pBzUQgulRIX5Mdd7JBGR_Meabm4vucreocW-xwT9YGu7JiRbpxDm4c5t_32mcZAN4fe5P2RmtDStU927Ez2YUdvfx1ztD68I6-d6Qa8et4vyfcvm_v19WJ7-_VmvdoubMmqvLBggXGHhWsAmHJWycaUrUEp6oLxUtbGNE2LqCRAA5YhlFgp1UqUNW-FuCQ3J24bzYPukz-YdNTReP10EdNOm5S97VADd2AKM1Nk4VreVIXkSqkGXCkc4MT6dGL1Y3PA1mLIyXQvoC9fgt_rXXzUlQBRsXoCfHgGpPhzxCHrgx8sdp0JGMdBT5IU5wCqnKLqFLUpDkNCp63P0xfGmew7DUzPlvWTZT1b1ifLUxP-af4Z8P-d38J-q10 |
| CitedBy_id | crossref_primary_10_1016_j_neubiorev_2022_104793 crossref_primary_10_3389_fphar_2021_749068 crossref_primary_10_1007_s00210_023_02778_x crossref_primary_10_1007_s00213_022_06092_x crossref_primary_10_1124_pharmrev_121_000514 crossref_primary_10_3389_fpsyt_2022_990405 crossref_primary_10_3390_biom12111618 crossref_primary_10_1038_s41598_024_74810_w crossref_primary_10_1007_s40263_023_01008_5 crossref_primary_10_3389_fphar_2022_927984 crossref_primary_10_1007_s40429_025_00638_7 crossref_primary_10_1038_s41386_024_01972_6 crossref_primary_10_1177_02698811221093793 crossref_primary_10_1038_s41380_024_02743_x crossref_primary_10_1080_10508619_2022_2148061 crossref_primary_10_3389_fphar_2023_1239159 crossref_primary_10_1016_j_neuropharm_2025_110413 crossref_primary_10_3390_ijms24021329 crossref_primary_10_3389_fpsyg_2023_1100058 crossref_primary_10_1038_s41386_022_01297_2 crossref_primary_10_1007_s00213_022_06279_2 crossref_primary_10_1111_jnc_15607 crossref_primary_10_1111_jnc_70020 crossref_primary_10_3389_fpain_2025_1527783 crossref_primary_10_1038_s44184_023_00053_8 crossref_primary_10_3389_fpsyg_2022_812930 crossref_primary_10_3390_biology12111380 crossref_primary_10_1002_advs_202402493 crossref_primary_10_3390_ph15050640 crossref_primary_10_3389_fphar_2022_906639 crossref_primary_10_1038_s41380_023_02360_0 crossref_primary_10_3389_fpsyg_2021_749788 crossref_primary_10_1177_02698811231155117 crossref_primary_10_1186_s40337_024_01185_8 crossref_primary_10_1038_s41386_023_01607_2 crossref_primary_10_1038_s41386_023_01609_0 crossref_primary_10_1038_s44220_024_00302_5 crossref_primary_10_1080_14740338_2022_2066650 crossref_primary_10_1016_j_bpsc_2024_02_001 crossref_primary_10_1016_j_euroneuro_2023_05_008 crossref_primary_10_1038_s41380_024_02875_0 |
| Cites_doi | 10.1038/nature03701 10.1371/journal.pone.0100719 10.1111/jne.12374 10.1007/s10803-007-0486-x 10.3389/fphar.2017.00814 10.1016/j.neuroscience.2007.02.032 10.1093/cercor/bhx257 10.1038/tp.2017.54 10.1007/s00213-017-4650-5 10.1007/s00213-017-4733-3 10.1177/0269881108094300 10.1111/bph.15481 10.1177/0269881120959604 10.1111/acps.12818 10.1007/s00213-014-3714-z 10.1177/0269881108095705 10.1021/acsptsci.0c00099 10.1016/j.biopsych.2014.11.015 10.1038/npp.2016.82 10.7554/eLife.35082 10.1038/s41386-020-00883-6 10.1097/NMD.0000000000000113 10.1093/scan/nst161 10.1016/j.biopsych.2021.01.016 10.1016/j.euroneuro.2015.01.009 10.1080/17470910802649470 10.2165/00003088-199120040-00002 10.1523/JNEUROSCI.5538-09.2010 10.1016/j.cub.2016.12.030 10.1093/ijnp/pyv072 10.1371/journal.pone.0036476 10.1016/j.brainresbull.2011.06.011 10.1016/S0924-9338(15)30017-1 10.1177/0269881114542454 10.1177/0269881116663120 10.1177/02698811211015221 10.1016/j.nicl.2018.03.005 10.1111/bcp.13918 10.1016/j.biopsych.2008.10.011 10.1097/PSY.0b013e318187aef7 10.1007/s00213-017-4610-0 10.1016/j.psyneuen.2016.08.011 10.1017/S0033291715002901 10.1016/j.celrep.2018.05.022 10.1038/s41386-019-0569-3 10.1016/j.euroneuro.2016.05.001 10.1073/pnas.1518377113 |
| ContentType | Journal Article |
| Copyright | Copyright © 2021 Holze, Avedisian, Varghese, Eckert and Liechti. Copyright © 2021 Holze, Avedisian, Varghese, Eckert and Liechti. 2021 Holze, Avedisian, Varghese, Eckert and Liechti |
| Copyright_xml | – notice: Copyright © 2021 Holze, Avedisian, Varghese, Eckert and Liechti. – notice: Copyright © 2021 Holze, Avedisian, Varghese, Eckert and Liechti. 2021 Holze, Avedisian, Varghese, Eckert and Liechti |
| DBID | AAYXX CITATION 7X8 5PM DOA |
| DOI | 10.3389/fphar.2021.711255 |
| DatabaseName | CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals (WRLC) url: https://www.doaj.org/ sourceTypes: Open Website |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| DocumentTitleAlternate | Holze et al |
| EISSN | 1663-9812 |
| ExternalDocumentID | oai_doaj_org_article_12f1a4ab1c064fd2b8462777b1f53f1e PMC8313809 10_3389_fphar_2021_711255 |
| GrantInformation_xml | – fundername: Schweizerischer Nationalfonds Zur Förderung der Wissenschaftlichen Forschung – fundername: Universität Basel |
| GroupedDBID | 53G 5VS 9T4 AAFWJ AAKDD AAYXX ACGFO ACGFS ACXDI ADBBV ADRAZ AENEX AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK EMOBN GROUPED_DOAJ GX1 HYE KQ8 M48 M~E O5R O5S OK1 P2P PGMZT RNS RPM 7X8 5PM |
| ID | FETCH-LOGICAL-c508t-c1c102fe4fb1107fc76ba5dae639402569aabbdee7611b1c0e15e877d6e692d33 |
| IEDL.DBID | M48 |
| ISSN | 1663-9812 |
| IngestDate | Wed Aug 27 00:58:32 EDT 2025 Thu Aug 21 14:09:26 EDT 2025 Thu Jul 10 23:43:34 EDT 2025 Tue Jul 01 03:27:29 EDT 2025 Thu Apr 24 22:59:46 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c508t-c1c102fe4fb1107fc76ba5dae639402569aabbdee7611b1c0e15e877d6e692d33 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Charles D. Nichols, Louisiana State University, United States Danilo De Gregorio, McGill University, Canada This article was submitted to Neuropharmacology, a section of the journal Frontiers in Pharmacology Edited by: Katrin H. Preller, University of Zurich, Switzerland |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.3389/fphar.2021.711255 |
| PMID | 34326773 |
| PQID | 2557221175 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_12f1a4ab1c064fd2b8462777b1f53f1e pubmedcentral_primary_oai_pubmedcentral_nih_gov_8313809 proquest_miscellaneous_2557221175 crossref_citationtrail_10_3389_fphar_2021_711255 crossref_primary_10_3389_fphar_2021_711255 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2021-07-13 |
| PublicationDateYYYYMMDD | 2021-07-13 |
| PublicationDate_xml | – month: 07 year: 2021 text: 2021-07-13 day: 13 |
| PublicationDecade | 2020 |
| PublicationTitle | Frontiers in pharmacology |
| PublicationYear | 2021 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | Schmid (B45) 2018; 235 Ly (B32) 2018; 23 Preller (B37) 2018; 7 Carhart-Harris (B5) 2015; 232 Kraehenmann (B30); 234 Mueller (B33); 7 Griffiths (B18) 2008; 22 Barrett (B1) 2018; 28 Hunt (B23) 2011; 86 Gasser (B17) 2014; 202 Preller (B38) 2017; 27 Dolder (B11) 2018; 235 de Wit (B7) Holze (B20) 2019; 85 Strajhar (B46) 2016; 28 Bershad (B3) 2016; 30 Holze (B21) 2021; 46 Müller (B35); 136 Carhart-Harris (B4); 46 Rae (B40) 2021 de Wit (B8); 89 Persson (B36) 1991; 20 Hysek (B27) 2012; 7 Di Simplicio (B9) 2009; 23 Rickli (B41) 2016; 26 Schmid (B43) 2021; 35 Kuypers (B31) 2014; 9 Preller (B39) 2015; 30 Thompson (B47) 2007; 146 Schmid (B42) 2015; 78 Dumont (B14) 2009; 4 Carhart-Harris (B6); 113 Bernasconi (B2) 2015; 25 Ditzen (B10) 2009; 65 Hutten (B25) 2020; 4 Francis (B16) 2016; 74 Dolder (B13) 2016; 41 Holze (B22) 2020; 45 Kraehenmann (B29); 8 Kosfeld (B28) 2005; 435 Schmid (B44) 2014; 28 Dolder (B12) 2015; 19 Müller (B34) 2018; 18 Hysek (B26) 2014; 9 Holt-Lunstad (B19) 2008; 70 Hurlemann (B24) 2010; 30 Dziobek (B15) 2008; 38 |
| References_xml | – volume: 435 start-page: 673 year: 2005 ident: B28 article-title: Oxytocin Increases Trust in Humans publication-title: Nature doi: 10.1038/nature03701 – volume: 9 start-page: e100719 year: 2014 ident: B31 article-title: No Evidence that MDMA-Induced Enhancement of Emotional Empathy Is Related to Peripheral Oxytocin Levels or 5-HT1a Receptor Activation publication-title: PLoS One doi: 10.1371/journal.pone.0100719 – volume: 28 start-page: 12374 year: 2016 ident: B46 article-title: Acute Effects of Lysergic Acid Diethylamide on Circulating Steroid Levels in Healthy Subjects publication-title: J. Neuroendocrinol doi: 10.1111/jne.12374 – volume: 38 start-page: 464 year: 2008 ident: B15 article-title: Dissociation of Cognitive and Emotional Empathy in Adults with Asperger Syndrome Using the Multifaceted Empathy Test (MET) publication-title: J. Autism Dev. Disord. doi: 10.1007/s10803-007-0486-x – volume: 8 start-page: 814 ident: B29 article-title: LSD Increases Primary Process Thinking via Serotonin 2A Receptor Activation publication-title: Front. Pharmacol. doi: 10.3389/fphar.2017.00814 – volume: 146 start-page: 509 year: 2007 ident: B47 article-title: A Role for Oxytocin and 5-HT1A Receptors in the Prosocial Effects of 3,4 Methylenedioxymethamphetamine ("ecstasy") publication-title: Neuroscience doi: 10.1016/j.neuroscience.2007.02.032 – volume: 28 start-page: 3939 year: 2018 ident: B1 article-title: Serotonin 2A Receptor Signaling Underlies LSD-Induced Alteration of the Neural Response to Dynamic Changes in Music publication-title: Cereb. Cortex doi: 10.1093/cercor/bhx257 – volume: 7 start-page: e1084 ident: B33 article-title: Acute Effects of LSD on Amygdala Activity during Processing of Fearful Stimuli in Healthy Subjects publication-title: Transl Psychiatry doi: 10.1038/tp.2017.54 – volume: 235 start-page: 467 year: 2018 ident: B11 article-title: Direct Comparison of the Acute Subjective, Emotional, Autonomic, and Endocrine Effects of MDMA, Methylphenidate, and Modafinil in Healthy Subjects publication-title: Psychopharmacology doi: 10.1007/s00213-017-4650-5 – volume: 235 start-page: 535 year: 2018 ident: B45 article-title: Long-lasting Subjective Effects of LSD in normal Subjects publication-title: Psychopharmacology doi: 10.1007/s00213-017-4733-3 – volume: 22 start-page: 621 year: 2008 ident: B18 article-title: Mystical-type Experiences Occasioned by Psilocybin Mediate the Attribution of Personal Meaning and Spiritual Significance 14 Months Later publication-title: J. Psychopharmacol. doi: 10.1177/0269881108094300 – year: 2021 ident: B40 article-title: Oxytocin and Vasopressin: Signalling, Behavioural Modulation and Potential Therapeutic Effects publication-title: Br. J. Pharmacol. doi: 10.1111/bph.15481 – volume: 35 start-page: 362 year: 2021 ident: B43 article-title: Acute Subjective Effects in LSD- and MDMA-Assisted Psychotherapy publication-title: J. Psychopharmacol. doi: 10.1177/0269881120959604 – volume: 136 start-page: 648 ident: B35 article-title: Increased Thalamic Resting-State Connectivity as a Core Driver of LSD-Induced Hallucinations publication-title: Acta Psychiatr. Scand. doi: 10.1111/acps.12818 – volume: 232 start-page: 785 year: 2015 ident: B5 article-title: LSD Enhances Suggestibility in Healthy Volunteers publication-title: Psychopharmacology doi: 10.1007/s00213-014-3714-z – volume: 23 start-page: 241 year: 2009 ident: B9 article-title: Oxytocin Enhances Processing of Positive versus Negative Emotional Information in Healthy Male Volunteers publication-title: J. Psychopharmacol. doi: 10.1177/0269881108095705 – volume: 4 start-page: 461 year: 2020 ident: B25 article-title: Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers publication-title: ACS Pharmacol. Transl. Sci. doi: 10.1021/acsptsci.0c00099 – volume: 78 start-page: 544 year: 2015 ident: B42 article-title: Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2014.11.015 – volume: 41 start-page: 2638 year: 2016 ident: B13 article-title: LSD Acutely Impairs Fear Recognition and Enhances Emotional Empathy and Sociality publication-title: Neuropsychopharmacol doi: 10.1038/npp.2016.82 – volume: 7 start-page: e35082 year: 2018 ident: B37 article-title: Changes in Global and Thalamic Brain Connectivity in LSD-Induced Altered States of Consciousness Are Attributable to the 5-HT2A Receptor publication-title: Elife doi: 10.7554/eLife.35082 – volume: 46 start-page: 537 year: 2021 ident: B21 article-title: Acute Dose-dependent Effects of Lysergic Acid Diethylamide in a Double-Blind Placebo-Controlled Study in Healthy Subjects publication-title: Neuropsychopharmacol. doi: 10.1038/s41386-020-00883-6 – volume: 202 start-page: 513 year: 2014 ident: B17 article-title: Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated with Life-Threatening Diseases publication-title: J. Nerv Ment. Dis. doi: 10.1097/NMD.0000000000000113 – volume: 9 start-page: 1645 year: 2014 ident: B26 article-title: MDMA Enhances Emotional Empathy and Prosocial Behavior publication-title: Soc. Cogn. Affect Neurosci. doi: 10.1093/scan/nst161 – volume: 89 start-page: e61 ident: B8 article-title: Can MDMA Change Sociopolitical Values? Insights from a Research Participant publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2021.01.016 – volume: 25 start-page: 474 year: 2015 ident: B2 article-title: The Electrophysiological Effects of the Serotonin 1A Receptor Agonist Buspirone in Emotional Face Processing publication-title: Eur. Neuropsychopharmacol. doi: 10.1016/j.euroneuro.2015.01.009 – volume: 4 start-page: 359 year: 2009 ident: B14 article-title: Increased Oxytocin Concentrations and Prosocial Feelings in Humans after Ecstasy (3,4-methylenedioxymethamphetamine) Administration publication-title: Soc. Neurosci. doi: 10.1080/17470910802649470 – volume: 20 start-page: 263 year: 1991 ident: B36 article-title: Clinical Pharmacokinetics of Ketanserin publication-title: Clin. Pharmacokinet. doi: 10.2165/00003088-199120040-00002 – volume: 30 start-page: 4999 year: 2010 ident: B24 article-title: Oxytocin Enhances Amygdala-dependent, Socially Reinforced Learning and Emotional Empathy in Humans publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.5538-09.2010 – volume: 27 start-page: 451 year: 2017 ident: B38 article-title: The Fabric of Meaning and Subjective Effects in LSD-Induced States Depend on Serotonin 2A Receptor Activation publication-title: Curr. Biol. doi: 10.1016/j.cub.2016.12.030 – volume: 19 start-page: pyv072 year: 2015 ident: B12 article-title: Pharmacokinetics and Concentration-Effect Relationship of Oral LSD in Humans publication-title: Ijnppy doi: 10.1093/ijnp/pyv072 – volume: 7 start-page: e36476 year: 2012 ident: B27 article-title: Duloxetine Inhibits Effects of MDMA ("ecstasy") In Vitro and in Humans in a Randomized Placebo-Controlled Laboratory Study publication-title: PLoS One doi: 10.1371/journal.pone.0036476 – volume: 86 start-page: 65 year: 2011 ident: B23 article-title: MDMA-induced C-Fos Expression in Oxytocin-Containing Neurons Is Blocked by Pretreatment with the 5-HT-1A Receptor Antagonist WAY 100635 publication-title: Brain Res. Bull. doi: 10.1016/j.brainresbull.2011.06.011 – volume: 30 start-page: 22 year: 2015 ident: B39 article-title: The Effect of 5-HT2A/1a Agonist Treatment on Social Cognition, Empathy, and Social Decision-Making publication-title: Eur. Psychiatry doi: 10.1016/S0924-9338(15)30017-1 – volume: 28 start-page: 847 year: 2014 ident: B44 article-title: Differential Effects of MDMA and Methylphenidate on Social Cognition publication-title: J. Psychopharmacol. doi: 10.1177/0269881114542454 – volume: 30 start-page: 1248 year: 2016 ident: B3 article-title: The Effects of MDMA on Socio-Emotional Processing: Does MDMA Differ from Other Stimulants? publication-title: J. Psychopharmacol. doi: 10.1177/0269881116663120 – start-page: 026988112110152 ident: B7 article-title: Challenges in Translational Research: MDMA in the Laboratory versus Therapeutic Settings publication-title: J. Psychopharmacol. doi: 10.1177/02698811211015221 – volume: 18 start-page: 694 year: 2018 ident: B34 article-title: Altered Network Hub Connectivity after Acute LSD Administration publication-title: Neuroimage Clin. doi: 10.1016/j.nicl.2018.03.005 – volume: 85 start-page: 1474 year: 2019 ident: B20 article-title: Pharmacokinetics and Subjective Effects of a Novel Oral LSD Formulation in Healthy Subjects publication-title: Br. J. Clin. Pharmacol. doi: 10.1111/bcp.13918 – volume: 65 start-page: 728 year: 2009 ident: B10 article-title: Intranasal Oxytocin Increases Positive Communication and Reduces Cortisol Levels during Couple Conflict publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2008.10.011 – volume: 70 start-page: 976 year: 2008 ident: B19 article-title: Influence of a "warm Touch" Support Enhancement Intervention Among Married Couples on Ambulatory Blood Pressure, Oxytocin, Alpha Amylase, and Cortisol publication-title: Psychosom Med. doi: 10.1097/PSY.0b013e318187aef7 – volume: 234 start-page: 2031 ident: B30 article-title: Dreamlike Effects of LSD on Waking Imagery in Humans Depend on Serotonin 2A Receptor Activation publication-title: Psychopharmacology doi: 10.1007/s00213-017-4610-0 – volume: 74 start-page: 92 year: 2016 ident: B16 article-title: Urinary and Plasma Oxytocin Changes in Response to MDMA or Intranasal Oxytocin Administration publication-title: Psychoneuroendocrinology doi: 10.1016/j.psyneuen.2016.08.011 – volume: 46 start-page: 1379 ident: B4 article-title: The Paradoxical Psychological Effects of Lysergic Acid Diethylamide (LSD) publication-title: Psychol. Med. doi: 10.1017/S0033291715002901 – volume: 23 start-page: 3170 year: 2018 ident: B32 article-title: Psychedelics Promote Structural and Functional Neural Plasticity publication-title: Cell Rep. doi: 10.1016/j.celrep.2018.05.022 – volume: 45 start-page: 462 year: 2020 ident: B22 article-title: Distinct Acute Effects of LSD, MDMA, and D-Amphetamine in Healthy Subjects publication-title: Neuropsychopharmacol. doi: 10.1038/s41386-019-0569-3 – volume: 26 start-page: 1327 year: 2016 ident: B41 article-title: Receptor Interaction Profiles of Novel Psychoactive Tryptamines Compared with Classic Hallucinogens publication-title: Eur. Neuropsychopharmacol. doi: 10.1016/j.euroneuro.2016.05.001 – volume: 113 start-page: 4853 ident: B6 article-title: Neural Correlates of the LSD Experience Revealed by Multimodal Neuroimaging publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1518377113 |
| SSID | ssj0000399364 |
| Score | 2.4638777 |
| Snippet | The psychedelic lysergic acid diethylamide (LSD) has experienced a revival in research, including clinical trials that evaluate LSD-assisted psychotherapy. LSD... |
| SourceID | doaj pubmedcentral proquest crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Enrichment Source Index Database |
| StartPage | 711255 |
| SubjectTerms | 5-HT2A receptor emotion processing empathy ketanserin LSD oxytocin Pharmacology |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3JbtswECWKnHIp0g112xRToMihiBKTWigd3SwwimxoHCQ3gqKGjYGEMmIZqP--M5KTWJf20qtEgRLfiO8NJb4R4qtz6TDRzkUkhn2USEXzYOxsROxQ6LSyRKG8Dnl6lo2vkh836c1aqS_-J6yzB-4Gbl8qL21iS-mIPH2lSiJMpbUupU9jL5FnX-K8tWSqnYOZd7Ok-4xJWVix72e3lv0_ldzTpDF4a98aEbV-_T2R2f9Fco1zjrfEy5VYhFF3k6_ECwyvxc5F5za93IXJ8-ap-S7swMWzD_Xyjbj-Wd8h1B5I40EajSdqBKQScUZpNkwDjNyiQejsi-fc7uTyEOoAR_dcpngJNlRwMH1wbYGv8AvOfy8bgjK8FVfHR5ODcbSqoxAREHkTOelIRnhMfMnZnnc6Ky3hgBmXRSfNU1hblhWizqTkgUaZYq51lWFWqCqO34mNUAd8LyDnSh1FUSEhkei8sg5jEgSJ9ZwHyWIgho-DatzKZJxrXdwZSjYYB9PiYBgH0-EwEN-eLpl1Dht_a_ydkXpqyObY7QEKGbMKGfOvkBmIL484G3qZ-AuJDVgv5oZ60Eqxe-lA6F4A9HrsnwnT29aWO49lnA-LD__jFj-KTX5qXkSW8Sex0TwscJvUT1N-bgP9D_BlAq4 priority: 102 providerName: Directory of Open Access Journals |
| Title | Role of the 5-HT2A Receptor in Acute Effects of LSD on Empathy and Circulating Oxytocin |
| URI | https://www.proquest.com/docview/2557221175 https://pubmed.ncbi.nlm.nih.gov/PMC8313809 https://doaj.org/article/12f1a4ab1c064fd2b8462777b1f53f1e |
| Volume | 12 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1db9MwFLXGkNBeEJ-iMCYjoT2gZdQfsZMHhMrYVCEGE7Rib5Hj2Ful4nRtKi3_nnuTdCPSxAOviZ0PH9v3XCc-h5C31sZDqa2NgAz7SDIO86CwJoLokOq4MBBCcR3y9JsaT-WX8_h8i2zsrboGXN2Z2qGf1HQ5P7y-qj_CgP-AGSdc8r1fXBqU9uTsUAN9iON75D4EJo1ODqcd228mZgzGSrbfNu-uuUMe4E5LpbXoBapGz79HQvu_UP4Vk04ekYcdmaSjFv3HZMuFJ2T_rFWjrg_o5HZz1eqA7tOzW53q-in59aOcO1p6ChyQxtF4wkcUWKRbQBpOZ4GO7LpytJU3XmG5rz8_0zLQ499oY1xTEwp6NFvaxgAsXNDv13UFUIdnZHpyPDkaR53PQgRAJVVkmQWa4Z30OWaD3mqVG8DJKbRNB06UGpPnhXNaMZYzO3QsdonWhXIq5YUQz8l2KIN7QWiCTh5pWjhfcKmTwlgngDBI4zFPYumADDeNmtlOhBy9MOYZJCMISdZAkiEkWQvJgLy7qbJoFTj-VfgTInVTEMWzmwPl8iLrxmLGuGdGGnwTJeFBc-BgXGudMx8Lz9yAvNngnMFgwy8oJrhyvcrgDppzVDcdEN3rAL079s-E2WUj250IJpJh-vK_a74iO_iquLLMxC7ZrpZr9xooUZXvNUsJe013_wMRogxL |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Role+of+the+5-HT2A+Receptor+in+Acute+Effects+of+LSD+on+Empathy+and+Circulating+Oxytocin&rft.jtitle=Frontiers+in+pharmacology&rft.au=Holze%2C+Friederike&rft.au=Avedisian%2C+Isidora&rft.au=Varghese%2C+Nimmy&rft.au=Eckert%2C+Anne&rft.date=2021-07-13&rft.pub=Frontiers+Media+S.A&rft.eissn=1663-9812&rft.volume=12&rft_id=info:doi/10.3389%2Ffphar.2021.711255&rft_id=info%3Apmid%2F34326773&rft.externalDocID=PMC8313809 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1663-9812&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1663-9812&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1663-9812&client=summon |