Elevation of miR-221 and -222 in the internal mammary arteries of diabetic subjects and normalization with metformin

• Published in: Molecular and cellular endocrinology Vol. 374; no. 1-2; pp. 125 - 129
• Main Authors: Coleman, Chasity B., Lightell, Daniel J., Moss, Stephanie C., Bates, Michael, Parrino, Patrick E., Woods, T. Cooper
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 15.07.2013
• Subjects: Aged; Biopsy; cardiovascular diseases; Cardiovascular Diseases - complications; Cardiovascular Diseases - drug therapy; Cardiovascular Diseases - genetics; Cardiovascular Diseases - surgery; Coronary Artery Bypass; coronary vessels; Cross-Sectional Studies; Diabetes; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - surgery; Female; Gene Expression Regulation; Humans; Hypoglycemic Agents - pharmacology; Internal mammary artery; Male; Mammary Arteries - metabolism; Mammary Arteries - pathology; Mammary Arteries - surgery; messenger RNA; Metformin; Metformin - pharmacology; microRNA; MicroRNAs - antagonists & inhibitors; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; miR-221/222; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - pathology; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - metabolism; Myocytes, Smooth Muscle - pathology; Primary Cell Culture; risk factors; smooth muscle; Vascular smooth muscle cell; CVD; AMPK; Vascular smooth muscle cell; VSMC; Diabetes; Metformin; Internal mammary artery; IMA; miR-221/222

•miR-221/222 accelerate cell proliferation and intimal thickening.•miR-221/222 are elevated in the internal mammary arteries of diabetic subjects.•Diabetic subjects on metformin therapy exhibit normal miR-221/222 levels. Diabetes is a major risk factor for cardiovascular disease and is associated wi...