Gadolinium-staining reveals amyloid plaques in the brain of Alzheimer's transgenic mice

• Published in: Neurobiology of aging Vol. 33; no. 8; pp. 1533 - 1544
• Main Authors: Petiet, Alexandra, Santin, Mathieu, Bertrand, Anne, Wiggins, Christopher J, Petit, Fanny, Houitte, Diane, Hantraye, Philippe, Benavides, Jesus, Debeir, Thomas, Rooney, Thomas, Dhenain, Marc
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2012; Elsevier
• Subjects: Aging; Alzheimer; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid; Animals; beta -Amyloid; Biomarker; biomarkers; Brain - metabolism; Brain - pathology; Contrast agent; Contrast Media; Cortex; Female; Gadolinium; Gadolinium - pharmacokinetics; Hippocampus; Human health and pathology; Image processing; Internal Medicine; Life Sciences; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Mice; Mice, Transgenic; Molecular Imaging - methods; MRI; Nervous system; Neurodegenerative diseases; Neuroimaging; Neurology; Plaque, Amyloid - metabolism; Plaques; Sensory Organs; Staining and Labeling - methods; Tissue Distribution; Transgenic mice; Gadolinium; Biomarker; Amyloid; MRI; Alzheimer; Contrast agent

Abstract Detection of amyloid plaques in the brain by in vivo neuroimaging is a very promising biomarker approach for early diagnosis of Alzheimer's disease (AD) and evaluation of therapeutic efficacy. Here we describe a new method to detect amyloid plaques by in vivo magnetic resonance imaging...