Gadolinium-staining reveals amyloid plaques in the brain of Alzheimer's transgenic mice

Abstract Detection of amyloid plaques in the brain by in vivo neuroimaging is a very promising biomarker approach for early diagnosis of Alzheimer's disease (AD) and evaluation of therapeutic efficacy. Here we describe a new method to detect amyloid plaques by in vivo magnetic resonance imaging...

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Published inNeurobiology of aging Vol. 33; no. 8; pp. 1533 - 1544
Main Authors Petiet, Alexandra, Santin, Mathieu, Bertrand, Anne, Wiggins, Christopher J, Petit, Fanny, Houitte, Diane, Hantraye, Philippe, Benavides, Jesus, Debeir, Thomas, Rooney, Thomas, Dhenain, Marc
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.2012
Elsevier
Subjects
Aging
Alzheimer
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer's disease
Amyloid
Animals
beta -Amyloid
Biomarker
biomarkers
Brain - metabolism
Brain - pathology
Contrast agent
Contrast Media
Cortex
Female
Gadolinium
Gadolinium - pharmacokinetics
Hippocampus
Human health and pathology
Image processing
Internal Medicine
Life Sciences
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Mice
Mice, Transgenic
Molecular Imaging - methods
MRI
Nervous system
Neurodegenerative diseases
Neuroimaging
Neurology
Plaque, Amyloid - metabolism
Plaques
Sensory Organs
Staining and Labeling - methods
Tissue Distribution
Transgenic mice
Gadolinium
Biomarker
Amyloid
MRI
Alzheimer
Contrast agent
Online AccessGet full text

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Abstract Abstract Detection of amyloid plaques in the brain by in vivo neuroimaging is a very promising biomarker approach for early diagnosis of Alzheimer's disease (AD) and evaluation of therapeutic efficacy. Here we describe a new method to detect amyloid plaques by in vivo magnetic resonance imaging (MRI) based on the intracerebroventricular injection of a nontargeted gadolinium (Gd)-based contrast agent, which rapidly diffuses throughout the brain and increases the signal and contrast of magnetic resonance (MR) images by shortening the T1 relaxation time. This gain in image sensitivity after in vitro and in vivo Gd staining significantly improves the detection and resolution of individual amyloid plaques in the cortex and hippocampus of AD transgenic mice. The improved image resolution is sensitive enough to demonstrate an age-dependent increase of amyloid plaque load and a good correlation between the amyloid load measured by μMRI and histology. These results provide the first demonstration that nontargeted Gd staining can enhance the detection of amyloid plaques to follow the progression of AD and to evaluate the activity of amyloid-lowering therapeutic strategies in longitudinal studies.
AbstractList Detection of amyloid plaques in the brain by in vivo neuroimaging is a very promising biomarker approach for early diagnosis of Alzheimer's disease (AD) and evaluation of therapeutic efficacy. Here we describe a new method to detect amyloid plaques by in vivo magnetic resonance imaging (MRI) based on the intracerebroventricular injection of a nontargeted gadolinium (Gd)-based contrast agent, which rapidly diffuses throughout the brain and increases the signal and contrast of magnetic resonance (MR) images by shortening the T1 relaxation time. This gain in image sensitivity after in vitro and in vivo Gd staining significantly improves the detection and resolution of individual amyloid plaques in the cortex and hippocampus of AD transgenic mice. The improved image resolution is sensitive enough to demonstrate an age-dependent increase of amyloid plaque load and a good correlation between the amyloid load measured by MRI and histology. These results provide the first demonstration that nontargeted Gd staining can enhance the detection of amyloid plaques to follow the progression of AD and to evaluate the activity of amyloid-lowering therapeutic strategies in longitudinal studies.
Detection of amyloid plaques in the brain by in vivo neuroimaging is a very promising biomarker approach for early diagnosis of Alzheimer's disease (AD) and evaluation of therapeutic efficacy. Here we describe a new method to detect amyloid plaques by in vivo magnetic resonance imaging (MRI) based on the intracerebroventricular injection of a nontargeted gadolinium (Gd)-based contrast agent, which rapidly diffuses throughout the brain and increases the signal and contrast of magnetic resonance (MR) images by shortening the T1 relaxation time. This gain in image sensitivity after in vitro and in vivo Gd staining significantly improves the detection and resolution of individual amyloid plaques in the cortex and hippocampus of AD transgenic mice. The improved image resolution is sensitive enough to demonstrate an age-dependent increase of amyloid plaque load and a good correlation between the amyloid load measured by mu MRI and histology. These results provide the first demonstration that nontargeted Gd staining can enhance the detection of amyloid plaques to follow the progression of AD and to evaluate the activity of amyloid-lowering therapeutic strategies in longitudinal studies.
Abstract Detection of amyloid plaques in the brain by in vivo neuroimaging is a very promising biomarker approach for early diagnosis of Alzheimer's disease (AD) and evaluation of therapeutic efficacy. Here we describe a new method to detect amyloid plaques by in vivo magnetic resonance imaging (MRI) based on the intracerebroventricular injection of a nontargeted gadolinium (Gd)-based contrast agent, which rapidly diffuses throughout the brain and increases the signal and contrast of magnetic resonance (MR) images by shortening the T1 relaxation time. This gain in image sensitivity after in vitro and in vivo Gd staining significantly improves the detection and resolution of individual amyloid plaques in the cortex and hippocampus of AD transgenic mice. The improved image resolution is sensitive enough to demonstrate an age-dependent increase of amyloid plaque load and a good correlation between the amyloid load measured by μMRI and histology. These results provide the first demonstration that nontargeted Gd staining can enhance the detection of amyloid plaques to follow the progression of AD and to evaluate the activity of amyloid-lowering therapeutic strategies in longitudinal studies.
Detection of amyloid plaques in the brain by in vivo neuroimaging is a very promising biomarker approach for early diagnosis of Alzheimer's disease (AD) and evaluation of therapeutic efficacy. Here we describe a new method to detect amyloid plaques by in vivo magnetic resonance imaging (MRI) based on the intracerebroventricular injection of a nontargeted gadolinium (Gd)-based contrast agent, which rapidly diffuses throughout the brain and increases the signal and contrast of magnetic resonance (MR) images by shortening the T1 relaxation time. This gain in image sensitivity after in vitro and in vivo Gd staining significantly improves the detection and resolution of individual amyloid plaques in the cortex and hippocampus of AD transgenic mice. The improved image resolution is sensitive enough to demonstrate an age-dependent increase of amyloid plaque load and a good correlation between the amyloid load measured by μMRI and histology. These results provide the first demonstration that nontargeted Gd staining can enhance the detection of amyloid plaques to follow the progression of AD and to evaluate the activity of amyloid-lowering therapeutic strategies in longitudinal studies.
Author Wiggins, Christopher J
Santin, Mathieu
Bertrand, Anne
Petit, Fanny
Dhenain, Marc
Hantraye, Philippe
Debeir, Thomas
Petiet, Alexandra
Benavides, Jesus
Houitte, Diane
Rooney, Thomas
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Issue 8
Keywords Gadolinium
Biomarker
Amyloid
MRI
Alzheimer
Contrast agent
Language English
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Snippet Abstract Detection of amyloid plaques in the brain by in vivo neuroimaging is a very promising biomarker approach for early diagnosis of Alzheimer's disease...
Detection of amyloid plaques in the brain by in vivo neuroimaging is a very promising biomarker approach for early diagnosis of Alzheimer's disease (AD) and...
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SubjectTerms Aging
Alzheimer
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer's disease
Amyloid
Animals
beta -Amyloid
Biomarker
biomarkers
Brain - metabolism
Brain - pathology
Contrast agent
Contrast Media
Cortex
Female
Gadolinium
Gadolinium - pharmacokinetics
Hippocampus
Human health and pathology
Image processing
Internal Medicine
Life Sciences
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Mice
Mice, Transgenic
Molecular Imaging - methods
MRI
Nervous system
Neurodegenerative diseases
Neuroimaging
Neurology
Plaque, Amyloid - metabolism
Plaques
Sensory Organs
Staining and Labeling - methods
Tissue Distribution
Transgenic mice
Title Gadolinium-staining reveals amyloid plaques in the brain of Alzheimer's transgenic mice
URI https://www.clinicalkey.es/playcontent/1-s2.0-S0197458011000819
https://dx.doi.org/10.1016/j.neurobiolaging.2011.03.009
https://www.ncbi.nlm.nih.gov/pubmed/21531045
https://search.proquest.com/docview/1020048282
https://search.proquest.com/docview/1034826531
https://inria.hal.science/hal-01439340
Volume 33
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