Histologic and Cost-Benefit Analysis of Laparoscopic Sleeve Gastrectomy Specimens Performed for Morbid Obesity

• Published in: Archives of pathology & laboratory medicine (1976) Vol. 145; no. 3; pp. 365 - 370
• Main Authors: Nowak, Klaudia, Di Palma, Adam, Chieu, Kenny, Quereshy, Fayez, Jackson, Timothy, Okrainec, Allan, Serra, Stefano, Chetty, Runjan
• Format: Journal Article
• Language: English
• Published: United States College of American Pathologists 01.03.2021
• Subjects: Adult; Analysis; Bariatric Surgery; Body weight loss; Care and treatment; Cost benefit analysis; Diagnostic specimens; Drug therapy; Economic aspects; Endoscopy; Female; Gastrectomy; Gastrectomy - economics; Gastric bypass; Gastrointestinal cancer; Gastrointestinal surgery; Health care networks; Helicobacter Infections - diagnosis; Helicobacter Infections - pathology; Helicobacter Infections - surgery; Helicobacter pylori - isolation & purification; Histology, Pathological; Humans; Hyperplasia; Intestine; Laparoscopic surgery; Laparoscopy; Laparoscopy - economics; Male; Medical care, Cost of; Metabolism; Metaplasia; Methods; Middle Aged; Neuroendocrine tumors; Obesity; Obesity, Morbid - diagnosis; Obesity, Morbid - pathology; Obesity, Morbid - surgery; Ontario; Patients; Proton pump inhibitors; Stomach; Surgery; Surgical outcomes; Weight control; Ontario; Canada; Toronto Ontario Canada; United States > US
• DOI: 10.5858/arpa.2020-0084-OA
• ISSN: 0003-9985; 1543-2165

Laparoscopic sleeve gastrectomy (LSG) has quickly become the bariatric surgical procedure of choice for patients with obesity who have failed medical management. Laparoscopic sleeve gastrectomy results in a gastric remnant that is routinely subject to pathologic examination. To perform a histologic and cost-benefit analysis of gastric remnants post-LSG. All LSG cases performed at University Health Network, Toronto, Ontario, Canada, between 2010 and 2019 were reviewed. Specimens that underwent routine histopathologic assessment and ancillary immunohistochemical analysis were analyzed. Baseline patient characteristics and surgical outcomes were obtained from our internal database. The total cost of specimen gross preparation, examination, sampling, and producing and reporting a hematoxylin-eosin slide was calculated. A total of 572 patients underwent LSG during the study period and had their specimens examined histologically. A mean of 4.87 blocks generating 4 hematoxylin-eosin slides was produced. The most common histologic findings reported in LSG specimens ranged from no pathologic abnormalities identified together with proton pump inhibitor-related change. A minority of cases demonstrated clinically actionable histologic findings, of which Helicobacter pylori infection was the most common. The total cost for the complete pathologic analysis of these cases amounted to CaD $66 383.10 (US $47 080.21) with a mean of CaD $116.05 (US $82.40) per case. A total of CaD $62 622.75 (US $44 413.30) was spent on full examination of cases that had no further postoperative clinical impact. There is a broad spectrum of pathologic findings in LSG specimens, ranging from clinically nonactionable to more clinically actionable. The vast majority of histologic findings had no clinical impact, with only a minority of cases being clinically significant. This study therefore recommends that LSG specimens be subject to gross pathologic examination in the vast majority of cases. However, sections should be submitted for microscopic analysis if grossly evident lesions are present and if there is a clinical/known history of clinically actionable findings.