Mycobacterium abscessus: a new antibiotic nightmare

The intrinsic and acquired resistance of Mycobacterium abscessus to commonly used antibiotics limits the chemotherapeutic options for infections caused by these mycobacteria. Intrinsic resistance is attributed to a combination of the permeability barrier of the complex multilayer cell envelope, drug...

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Published in	Journal of antimicrobial chemotherapy Vol. 67; no. 4; pp. 810 - 818
Main Authors	Nessar, Rachid, Cambau, Emmanuelle, Reyrat, Jean Marc, Murray, Alan, Gicquel, Brigitte
Format	Journal Article
Language	English
Published	Oxford Oxford University Press 01.04.2012 Oxford Publishing Limited (England)
Subjects	Aminoglycoside antibiotics Anti-Bacterial Agents - pharmacology Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobial agents Biological and medical sciences Cell envelopes Chemotherapy Cytoplasm Drug resistance Drug Resistance, Multiple, Bacterial Enzymes Humans Infection Infections Medical sciences Mutation Mycobacterium Mycobacterium - classification Mycobacterium - drug effects Mycobacterium abscessus Mycobacterium Infections - drug therapy Mycobacterium Infections - microbiology Pathogens Permeability Pharmacology. Drug treatments Reviews natural acquired resistance Resistance Antibiotic Mycobacteriales Acquired Mycobacteriaceae Bacteria Actinomycetes Antibacterial agent Mycobacterium abscessus
Online Access	Get full text
ISSN	0305-7453 1460-2091 1460-2091
DOI	10.1093/jac/dkr578

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Abstract	The intrinsic and acquired resistance of Mycobacterium abscessus to commonly used antibiotics limits the chemotherapeutic options for infections caused by these mycobacteria. Intrinsic resistance is attributed to a combination of the permeability barrier of the complex multilayer cell envelope, drug export systems, antibiotic targets with low affinity and enzymes that neutralize antibiotics in the cytoplasm. To date, acquired resistance has only been observed for aminoglycosides and macrolides, which is conferred by mutations affecting the genes encoding the antibiotic targets (rrs and rrl, respectively). Here we summarize previous and recent findings on the resistance of M. abscessus to antibiotics in light of what has been discovered for other mycobacteria. Since we can now distinguish three groups of strains belonging to M. abscessus (M. abscessus sensu stricto, Mycobacterium massiliense and Mycobacterium bolletii), studies on antibiotic susceptibility and resistance should be considered according to this new classification. This review raises the profile of this important pathogen and highlights the work needed to decipher the molecular events responsible for its extensive chemotherapeutic resistance.
AbstractList	The intrinsic and acquired resistance of Mycobacterium abscessus to commonly used antibiotics limits the chemotherapeutic options for infections caused by these mycobacteria. Intrinsic resistance is attributed to a combination of the permeability barrier of the complex multilayer cell envelope, drug export systems, antibiotic targets with low affinity and enzymes that neutralize antibiotics in the cytoplasm. To date, acquired resistance has only been observed for aminoglycosides and macrolides, which is conferred by mutations affecting the genes encoding the antibiotic targets (rrs and rrl, respectively). Here we summarize previous and recent findings on the resistance of M. abscessus to antibiotics in light of what has been discovered for other mycobacteria. Since we can now distinguish three groups of strains belonging to M. abscessus (M. abscessus sensu stricto, Mycobacterium massiliense and Mycobacterium bolletii), studies on antibiotic susceptibility and resistance should be considered according to this new classification. This review raises the profile of this important pathogen and highlights the work needed to decipher the molecular events responsible for its extensive chemotherapeutic resistance.The intrinsic and acquired resistance of Mycobacterium abscessus to commonly used antibiotics limits the chemotherapeutic options for infections caused by these mycobacteria. Intrinsic resistance is attributed to a combination of the permeability barrier of the complex multilayer cell envelope, drug export systems, antibiotic targets with low affinity and enzymes that neutralize antibiotics in the cytoplasm. To date, acquired resistance has only been observed for aminoglycosides and macrolides, which is conferred by mutations affecting the genes encoding the antibiotic targets (rrs and rrl, respectively). Here we summarize previous and recent findings on the resistance of M. abscessus to antibiotics in light of what has been discovered for other mycobacteria. Since we can now distinguish three groups of strains belonging to M. abscessus (M. abscessus sensu stricto, Mycobacterium massiliense and Mycobacterium bolletii), studies on antibiotic susceptibility and resistance should be considered according to this new classification. This review raises the profile of this important pathogen and highlights the work needed to decipher the molecular events responsible for its extensive chemotherapeutic resistance. The intrinsic and acquired resistance of Mycobacterium abscessus to commonly used antibiotics limits the chemotherapeutic options for infections caused by these mycobacteria. Intrinsic resistance is attributed to a combination of the permeability barrier of the complex multilayer cell envelope, drug export systems, antibiotic targets with low affinity and enzymes that neutralize antibiotics in the cytoplasm. To date, acquired resistance has only been observed for aminoglycosides and macrolides, which is conferred by mutations affecting the genes encoding the antibiotic targets (rrs and rrl, respectively). Here we summarize previous and recent findings on the resistance of M. abscessus to antibiotics in light of what has been discovered for other mycobacteria. Since we can now distinguish three groups of strains belonging to M. abscessus (M. abscessus sensu stricto, Mycobacterium massiliense and Mycobacterium bolletii), studies on antibiotic susceptibility and resistance should be considered according to this new classification. This review raises the profile of this important pathogen and highlights the work needed to decipher the molecular events responsible for its extensive chemotherapeutic resistance. The intrinsic and acquired resistance of Mycobacterium abscessus to commonly used antibiotics limits the chemotherapeutic options for infections caused by these mycobacteria. Intrinsic resistance is attributed to a combination of the permeability barrier of the complex multilayer cell envelope, drug export systems, antibiotic targets with low affinity and enzymes that neutralize antibiotics in the cytoplasm. To date, acquired resistance has only been observed for aminoglycosides and macrolides, which is conferred by mutations affecting the genes encoding the antibiotic targets (rrs and rrl, respectively). Here we summarize previous and recent findings on the resistance of M. abscessus to antibiotics in light of what has been discovered for other mycobacteria. Since we can now distinguish three groups of strains belonging to M. abscessus (M. abscessus sensu stricto, Mycobacterium massiliense and Mycobacterium bolletii), studies on antibiotic susceptibility and resistance should be considered according to this new classification. This review raises the profile of this important pathogen and highlights the work needed to decipher the molecular events responsible for its extensive chemotherapeutic resistance. [PUBLICATION ABSTRACT]
Author	Murray, Alan Nessar, Rachid Gicquel, Brigitte Reyrat, Jean Marc Cambau, Emmanuelle
Author_xml	– sequence: 1 givenname: Rachid surname: Nessar fullname: Nessar, Rachid organization: 1 Université Paris Descartes, Faculté de Médecine, F-75730 Paris cedex 15, France – sequence: 2 givenname: Emmanuelle surname: Cambau fullname: Cambau, Emmanuelle organization: 2 Université Paris Diderot, EA3964, APHP, Groupe Hospitalier Lariboisière-Saint Louis, Bactériologie, Paris 75010, France – sequence: 3 givenname: Jean Marc surname: Reyrat fullname: Reyrat, Jean Marc organization: 1 Université Paris Descartes, Faculté de Médecine, F-75730 Paris cedex 15, France – sequence: 4 givenname: Alan surname: Murray fullname: Murray, Alan organization: 3 Unité de Génétique Mycobactérienne, Institut Pasteur, Paris cedex 15, France – sequence: 5 givenname: Brigitte surname: Gicquel fullname: Gicquel, Brigitte email: bgicquel@pasteur.fr organization: 3 Unité de Génétique Mycobactérienne, Institut Pasteur, Paris cedex 15, France
BackLink	http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25637962$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/22290346$$D View this record in MEDLINE/PubMed
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Copyright	The Author 2012. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com 2012 2015 INIST-CNRS Copyright Oxford Publishing Limited(England) Apr 2012
Copyright_xml	– notice: The Author 2012. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com 2012 – notice: 2015 INIST-CNRS – notice: Copyright Oxford Publishing Limited(England) Apr 2012
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Snippet	The intrinsic and acquired resistance of Mycobacterium abscessus to commonly used antibiotics limits the chemotherapeutic options for infections caused by...
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SubjectTerms	Aminoglycoside antibiotics Anti-Bacterial Agents - pharmacology Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobial agents Biological and medical sciences Cell envelopes Chemotherapy Cytoplasm Drug resistance Drug Resistance, Multiple, Bacterial Enzymes Humans Infection Infections Medical sciences Mutation Mycobacterium Mycobacterium - classification Mycobacterium - drug effects Mycobacterium abscessus Mycobacterium Infections - drug therapy Mycobacterium Infections - microbiology Pathogens Permeability Pharmacology. Drug treatments Reviews
Title	Mycobacterium abscessus: a new antibiotic nightmare
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