Grb2 monomer–dimer equilibrium determines normal versus oncogenic function

• Published in: Nature communications Vol. 6; no. 1; p. 7354
• Main Authors: Ahmed, Zamal, Timsah, Zahra, Suen, Kin M., Cook, Nathan P., Lee, Gilbert R., Lin, Chi-Chuan, Gagea, Mihai, Marti, Angel A., Ladbury, John E.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.06.2015; Nature Publishing Group; Nature Pub. Group
• Subjects: 13; 14; 14/33; 631/67; 631/80/458/1733; 631/80/86; 692/420/755; Breast Neoplasms - metabolism; Colonic Neoplasms - metabolism; Female; GRB2 Adaptor Protein - chemistry; GRB2 Adaptor Protein - metabolism; HEK293 Cells; Humanities and Social Sciences; Humans; Male; MAP Kinase Signaling System; multidisciplinary; Phosphorylation; Prostatic Neoplasms - metabolism; Protein Multimerization; Science; Science (multidisciplinary); Signal Transduction; Son of Sevenless Proteins - metabolism; src Homology Domains; Tissue Array Analysis; Tyrosine - metabolism

The adaptor protein growth factor receptor-bound protein 2 (Grb2) is ubiquitously expressed in eukaryotic cells and involved in a multitude of intracellular protein interactions. Grb2 plays a pivotal role in tyrosine kinase-mediated signal transduction including linking receptor tyrosine kinases to...