An endoplasmic reticulum stress-related signature could robustly predict prognosis and closely associate with response to immunotherapy in pancreatic ductal adenocarcinoma

• Published in: Journal of cancer research and clinical oncology Vol. 149; no. 17; pp. 15589 - 15608
• Main Authors: Liu, Shuguang, Hu, Qianying, Xie, Zishan, Chen, Shaojing, Li, Yixuan, Quan, Nali, Huang, Kaimeng, Li, Riqing, Fang, Lishan
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2023; Springer Nature B.V
• Subjects: Adenocarcinoma; Algorithms; Calcium channels (voltage-gated); Cancer Research; Carcinoma, Pancreatic Ductal - drug therapy; Carcinoma, Pancreatic Ductal - genetics; Chemotherapy; drug therapy; Endoplasmic reticulum; endoplasmic reticulum stress; Endoribonucleases; genome; Genomes; Genotypes; Hematology; Humans; Immunosuppressive agents; Immunotherapy; Inhibitor drugs; Internal Medicine; Medical prognosis; Medicine; Medicine & Public Health; Membrane Proteins; Metastases; Oncology; Pancreas; Pancreatic cancer; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - genetics; Patients; Prognosis; Protein Serine-Threonine Kinases; regression analysis; risk; Risk groups; transcription (genetics); Transforming growth factor-b1; Prognosis; Immunotherapy response; Overall survival; Pancreatic ductal adenocarcinoma; Endoplasmic reticulum stress

Purpose Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors. Endoplasmic reticulum stress (ERS) plays an essential role in PDAC progression. Here, we aim to identify the ERS-related genes in PDAC and build reliable risk models for diagnosis, prognosis and immunotherapy respon...