Fetal Growth Restriction Caused by Sexual Transmission of Zika Virus in Mice

Zika virus (ZIKV) can be transmitted by mosquito bite or sexual contact. Using mice that lack the type I interferon receptor, we examined sexual transmission of ZIKV. Electron microscopy analyses showed association of virions with developing sperm within testes as well as with mature sperm within ep...

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Published inThe Journal of infectious diseases Vol. 215; no. 11; pp. 1720 - 1724
Main Authors Uraki, Ryuta, Jurado, Kellie Ann, Hwang, Jesse, Szigeti-Buck, Klara, Horvath, Tamas L., Iwasaki, Akiko, Fikrig, Erol
Format Journal Article
LanguageEnglish
Published US Oxford University Press 01.06.2017
Subjects
Animals
Brief Report
Disease Models, Animal
Female
Fetal Growth Retardation - virology
Male
Mice
Pregnancy
Pregnancy Complications, Infectious - virology
Sexually Transmitted Diseases, Viral - transmission
Sexually Transmitted Diseases, Viral - virology
VIRUSES
Zika Virus
Zika Virus Infection - transmission
Zika Virus Infection - virology
fetal growth abnormalities
electron microscopy
Zika virus
sexual transmission
Online AccessGet full text

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Abstract Zika virus (ZIKV) can be transmitted by mosquito bite or sexual contact. Using mice that lack the type I interferon receptor, we examined sexual transmission of ZIKV. Electron microscopy analyses showed association of virions with developing sperm within testes as well as with mature sperm within epididymis. When ZIKV-infected male mice were mated with naive female mice, the weight of fetuses at embryonic day 18.5 was significantly reduced compared with the control group. Additionally, we found ocular deformities in a minority of the fetuses. These results suggest that ZIKV causes fetal abnormalities after female mating with an infected male.
AbstractList Zika virus, which is associated with sperm, can be sexually transmitted from infected males to naive females and cause fetal growth restriction in mice. Zika virus (ZIKV) can be transmitted by mosquito bite or sexual contact. Using mice that lack the type I interferon receptor, we examined sexual transmission of ZIKV. Electron microscopy analyses showed association of virions with developing sperm within testes as well as with mature sperm within epididymis. When ZIKV-infected male mice were mated with naive female mice, the weight of fetuses at embryonic day 18.5 was significantly reduced compared with the control group. Additionally, we found ocular deformities in a minority of the fetuses. These results suggest that ZIKV causes fetal abnormalities after female mating with an infected male.
Summary Zika virus, which is associated with sperm, can be sexually transmitted from infected males to naive females and cause fetal growth restriction in mice. Abstract Zika virus (ZIKV) can be transmitted by mosquito bite or sexual contact. Using mice that lack the type I interferon receptor, we examined sexual transmission of ZIKV. Electron microscopy analyses showed association of virions with developing sperm within testes as well as with mature sperm within epididymis. When ZIKV-infected male mice were mated with naive female mice, the weight of fetuses at embryonic day 18.5 was significantly reduced compared with the control group. Additionally, we found ocular deformities in a minority of the fetuses. These results suggest that ZIKV causes fetal abnormalities after female mating with an infected male.
Zika virus (ZIKV) can be transmitted by mosquito bite or sexual contact. Using mice that lack the type I interferon receptor, we examined sexual transmission of ZIKV. Electron microscopy analyses showed association of virions with developing sperm within testes as well as with mature sperm within epididymis. When ZIKV-infected male mice were mated with naive female mice, the weight of fetuses at embryonic day 18.5 was significantly reduced compared with the control group. Additionally, we found ocular deformities in a minority of the fetuses. These results suggest that ZIKV causes fetal abnormalities after female mating with an infected male.
Zika virus (ZIKV) can be transmitted by mosquito bite or sexual contact. Using mice that lack the type I interferon receptor, we examined sexual transmission of ZIKV. Electron microscopy analyses showed association of virions with developing sperm within testes as well as with mature sperm within epididymis. When ZIKV-infected male mice were mated with naive female mice, the weight of fetuses at embryonic day 18.5 was significantly reduced compared with the control group. Additionally, we found ocular deformities in a minority of the fetuses. These results suggest that ZIKV causes fetal abnormalities after female mating with an infected male.Zika virus (ZIKV) can be transmitted by mosquito bite or sexual contact. Using mice that lack the type I interferon receptor, we examined sexual transmission of ZIKV. Electron microscopy analyses showed association of virions with developing sperm within testes as well as with mature sperm within epididymis. When ZIKV-infected male mice were mated with naive female mice, the weight of fetuses at embryonic day 18.5 was significantly reduced compared with the control group. Additionally, we found ocular deformities in a minority of the fetuses. These results suggest that ZIKV causes fetal abnormalities after female mating with an infected male.
Author Hwang, Jesse
Uraki, Ryuta
Fikrig, Erol
Horvath, Tamas L.
Jurado, Kellie Ann
Szigeti-Buck, Klara
Iwasaki, Akiko
AuthorAffiliation 4 Howard Hughes Medical Institute , Chevy Chase, Maryland
3 Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine , New Haven, Connecticut ; and
1 Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine
2 Department of Immunobiology , and
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– name: 4 Howard Hughes Medical Institute , Chevy Chase, Maryland
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ContentType Journal Article
Copyright Copyright © 2016 Oxford University Press on behalf of the Infectious Diseases Society of America
The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2017
The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
Copyright_xml – notice: Copyright © 2016 Oxford University Press on behalf of the Infectious Diseases Society of America
– notice: The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2017
– notice: The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
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Keywords fetal growth abnormalities
electron microscopy
Zika virus
sexual transmission
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Correspondence: E. Fikrig, MD, Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, Anlyan Center for Medical Research and Education, 300 Cedar St, New Haven, CT 06520 (erol.fikrig@yale.edu).
R. U. and K. A. J. contributed equally to this study.
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Snippet Zika virus (ZIKV) can be transmitted by mosquito bite or sexual contact. Using mice that lack the type I interferon receptor, we examined sexual transmission...
Summary Zika virus, which is associated with sperm, can be sexually transmitted from infected males to naive females and cause fetal growth restriction in...
Zika virus, which is associated with sperm, can be sexually transmitted from infected males to naive females and cause fetal growth restriction in mice. Zika...
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SubjectTerms Animals
Brief Report
Disease Models, Animal
Female
Fetal Growth Retardation - virology
Male
Mice
Pregnancy
Pregnancy Complications, Infectious - virology
Sexually Transmitted Diseases, Viral - transmission
Sexually Transmitted Diseases, Viral - virology
VIRUSES
Zika Virus
Zika Virus Infection - transmission
Zika Virus Infection - virology
Title Fetal Growth Restriction Caused by Sexual Transmission of Zika Virus in Mice
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