Immunogenicity and functional characterization of Leishmania-derived hepatitis C virus envelope glycoprotein complex

• Published in: Scientific reports Vol. 6; no. 1; p. 30627
• Main Authors: Grzyb, Katarzyna, Czarnota, Anna, Brzozowska, Agnieszka, Cieślik, Anna, Rąbalski, Łukasz, Tyborowska, Jolanta, Bieńkowska-Szewczyk, Krystyna
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.08.2016; Nature Publishing Group
• Subjects: 13; 13/1; 13/109; 631/250/255/234/2513/1551; 631/61/24/590/2294; 64; 64/60; 82/16; 82/80; 82/83; Animals; Antibodies, Neutralizing - blood; Antibody response; Cross Reactions; Cross-reactivity; Epitopes; Gene Expression; Genotypes; Glycoproteins; Hepacivirus - immunology; Hepatitis; Hepatitis C; Hepatitis C Antibodies - blood; Humanities and Social Sciences; Immune response; Immunogenicity; Leishmania - genetics; Mammalian cells; Mice; multidisciplinary; Recombinant Proteins - genetics; Recombinant Proteins - immunology; Science; Vaccines; Viral Envelope Proteins - genetics; Viral Envelope Proteins - immunology; Viral infections; Viral Vaccines - administration & dosage; Viral Vaccines - immunology

Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 are the main inducers of a cross-neutralizing antibody response which plays an important role in the early phase of viral infection. Correctly folded and immunologically active E1E2 complex can be expressed in mammalian cells, though the produ...