Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis

• Published in: Biochemical and biophysical research communications Vol. 403; no. 1; pp. 103 - 107
• Main Authors: Cheng, Xiaoyun, Xia, Weiya, Yang, Jer-Yen, Hsu, Jennifer L., Chou, Chao-Kai, Sun, Hui-Lung, Wyszomierski, Shannon L., Mills, Gordon B., Muller, William J., Yu, Dihua, Hung, Mien-Chie
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.12.2010
• Subjects: Animals; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell Transformation, Neoplastic - metabolism; Cell Transformation, Neoplastic - pathology; Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis; Epithelium - metabolism; Epithelium - pathology; Female; Humans; Lung metastasis; Lung Neoplasms - metabolism; Lung Neoplasms - secondary; Mammary Neoplasms, Experimental - metabolism; Mammary Neoplasms, Experimental - pathology; Mammary tumorigenesis; Mice; Mice, Transgenic; Mouse mammary tumor virus; p21; PKB/Akt; Proto-Oncogene Proteins c-akt - metabolism; p21

► Akt-activated p21 was primarily expressed in cytoplasm of cells in transgenic mice. ► Akt-activated p21 accelerated tumor onset in MMTV/neu mice. ► Akt-activated p21 promoted lung metastasis in MMTV/neu mice. ► In vivo evidence that cytoplasmic p21 functions as an oncogene. While p21 is well known...