The microbiome extends to subepidermal compartments of normal skin

• Published in: Nature communications Vol. 4; no. 1; p. 1431
• Main Authors: Nakatsuji, Teruaki, Chiang, Hsin-I., Jiang, Shangi B., Nagarajan, Harish, Zengler, Karsten, Gallo, Richard L.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 2013; Nature Publishing Group
• Subjects: 631/250; 631/326/2565/2134; Adipose tissue; Aged; Bacteria; Bacteria - genetics; DNA, Bacterial - genetics; DNA, Bacterial - isolation & purification; Epidermis; Epidermis - microbiology; Face - microbiology; Female; Humanities and Social Sciences; Humans; In Situ Hybridization; Male; Metagenome - genetics; Middle Aged; multidisciplinary; RNA, Ribosomal, 16S - genetics; Science; Science (multidisciplinary); Sequence Analysis, DNA

Commensal microbes on the skin surface influence the behaviour of cells below the epidermis. We hypothesized that bacteria or their products exist below the surface epithelium and thus permit physical interaction between microbes and dermal cells. Here to test this hypothesis, we employed multiple i...