Ultrafast ultrasound imaging pattern analysis reveals distinctive dynamic brain states and potent sub-network alterations in arthritic animals

• Published in: Scientific reports Vol. 10; no. 1; p. 10485
• Main Authors: Rahal, Line, Thibaut, Miguel, Rivals, Isabelle, Claron, Julien, Lenkei, Zsolt, Sitt, Jacobo D., Tanter, Mickael, Pezet, Sophie
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.06.2020; Nature Publishing Group
• Subjects: 631/378/1689/2610; 692/53/2422; Animal models; Animals; Arthritis; Arthritis - physiopathology; Bioengineering; Brain Mapping - methods; Chronic pain; Chronic Pain - physiopathology; Cognition - physiology; Cognitive ability; Connectome - methods; Emotions - physiology; Fluctuations; Hemodynamics - physiology; Human health and pathology; Humanities and Social Sciences; Imaging; Inflammation; Life Sciences; Male; Mental disorders; multidisciplinary; Neural networks; Neural Pathways - physiology; Neuroimaging; Neurological diseases; Neuronal Plasticity - physiology; Neurons and Cognition; Pain; Pathogenicity; Pathogens; Rats; Rats, Sprague-Dawley; Rhumatology and musculoskeletal system; Science; Science (multidisciplinary); Somatosensory cortex; Somatosensory Cortex - physiology; Therapeutic applications; Ultrasonic imaging; Ultrasonography - methods; Ultrasound

Chronic pain pathologies, which are due to maladaptive changes in the peripheral and/or central nervous systems, are debilitating diseases that affect 20% of the European adult population. A better understanding of the mechanisms underlying this pathogenesis would facilitate the identification of no...