Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy

• Published in: JNCI : Journal of the National Cancer Institute Vol. 107; no. 4; p. 1
• Main Authors: Ager, Eleanor I., Kozin, Sergey V., Kirkpatrick, Nathaniel D., Seano, Giorgio, Kodack, David P., Askoxylakis, Vasileios, Huang, Yuhui, Goel, Shom, Snuderl, Matija, Muzikansky, Alona, Finkelstein, Dianne M., Dransfield, Daniel T., Devy, Laetitia, Boucher, Yves, Fukumura, Dai, Jain, Rakesh K.
• Format: Journal Article
• Language: English
• Published: United States Oxford Publishing Limited (England) 01.04.2015; Oxford University Press
• Subjects: Amidines - pharmacology; Animals; Antibodies, Monoclonal - pharmacology; Antibodies, Monoclonal - therapeutic use; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Benzylamines - pharmacology; Breast Neoplasms - blood supply; Breast Neoplasms - drug therapy; Breast Neoplasms - immunology; Breast Neoplasms - metabolism; Breast Neoplasms - radiotherapy; Cell Line, Tumor; Dose Fractionation; Enzyme Inhibitors - pharmacology; Enzyme Inhibitors - therapeutic use; Enzymes; Female; Gene expression; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genotype & phenotype; Humans; Immunoglobulin G - blood; Immunoglobulins; Immunology; Macrophages - drug effects; Macrophages - enzymology; Mammary Neoplasms, Experimental; Matrix Metalloproteinase 14 - drug effects; Matrix Metalloproteinase 14 - metabolism; Mice; Neovascularization, Pathologic; Nitric Oxide Synthase Type II - antagonists & inhibitors; Nitric Oxide Synthase Type II - drug effects; Nitric Oxide Synthase Type II - metabolism; Phenotype; Radiation therapy; Signal Transduction - drug effects; Smad2 Protein - metabolism; Smad3 Protein - metabolism; Transforming Growth Factor beta - metabolism; Tumors; Up-Regulation

Matrix metalloproteinase (MMP) 14 may mediate tumor progression through vascular and immune-modulatory effects. Orthotopic murine breast tumors (4T1 and E0771 with high and low MMP14 expression, respectively; n = 5-10 per group) were treated with an anti-MMP14 inhibitory antibody (DX-2400), IgG cont...