Radiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer [11C]3MeO4AP

• Published in: EJNMMI research Vol. 14; no. 1; pp. 43 - 10
• Main Authors: Zhou, Yu-Peng, Wilks, Moses Q., Dhaynaut, Maeva, Guehl, Nicolas J., Vesper, Danielle R., Moon, Sung-Hyun, Rice, Peter A., El Fakhri, Georges, Normandin, Marc D., Brugarolas, Pedro
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 29.04.2024; Springer Nature B.V; SpringerOpen
• Subjects: [11C]3MeO4AP; Automation; Biodistribution; Brain; Cardiac Imaging; cGMP; Computed tomography; Data acquisition; Decay; Dosimeters; Dosimetry; Imaging; In vivo methods and tests; Medicine; Medicine & Public Health; Multiple sclerosis; Nuclear Medicine; Oncology; Organs; Original Research; Orthopedics; PET tracer; Positron emission; Primates; Radiation; Radiation dosage; Radiochemistry; Radiology; Synthesis; Tracers; Voltage-gated potassium channel; Automation; C]3MeO4AP; cGMP; Radiation dosimetry; [; PET tracer; Voltage-gated potassium channel; Biodistribution; [11C]3MeO4AP

Background 4-Aminopyridine (4AP) is a medication for the symptomatic treatment of multiple sclerosis. Several 4AP-based PET tracers have been developed for imaging demyelination. In preclinical studies, [ 11 C]3MeO4AP has shown promise due to its high brain permeability, high metabolic stability, hi...