Mitochondrial dysfunction in Parkinson’s disease – a key disease hallmark with therapeutic potential

Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic Parkinson’s disease (PD). However, strategies aimed at ameliorating mitochondrial dysfunction, including antioxidants, antidiabetic drugs, and iron chelators, have failed in disease-modification clinical trial...

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Published inMolecular neurodegeneration Vol. 18; no. 1; pp. 83 - 20
Main Authors Henrich, Martin T., Oertel, Wolfgang H., Surmeier, D. James, Geibl, Fanni F.
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 11.11.2023
BioMed Central
BMC
Subjects
Adenosine triphosphate
Antioxidants
Antioxidants - metabolism
Antioxidants - therapeutic use
Bioenergetics
Brain
Chelating agents
Clinical trials
Diabetes mellitus
Electron transport
Electron transport chain
Exenatide
Genotype & phenotype
Health aspects
Homeostasis
Humans
Liraglutide
Mitochondria
Mitochondria - metabolism
Mitochondrial dysfunction
Movement disorders
MPTP
Neurodegeneration
Neurodegenerative diseases
Neurons
Neurophysiology
Oxidative Stress
Parkinson Disease - metabolism
Parkinson's disease
Pathogenesis
Pathology
Quality control
Quality management
Synuclein
Transmitters
Antioxidants
Electron transport chain
Neuroprotective therapies
Mitochondria
Mitochondrial dysfunction
MPTP
Synuclein
Parkinson’s disease
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Abstract Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic Parkinson’s disease (PD). However, strategies aimed at ameliorating mitochondrial dysfunction, including antioxidants, antidiabetic drugs, and iron chelators, have failed in disease-modification clinical trials. In this review, we summarize the cellular determinants of mitochondrial dysfunction, including impairment of electron transport chain complex 1, increased oxidative stress, disturbed mitochondrial quality control mechanisms, and cellular bioenergetic deficiency. In addition, we outline mitochondrial pathways to neurodegeneration in the current context of PD pathogenesis, and review past and current treatment strategies in an attempt to better understand why translational efforts thus far have been unsuccessful.
AbstractList Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial dysfunction, including antioxidants, antidiabetic drugs, and iron chelators, have failed in disease-modification clinical trials. In this review, we summarize the cellular determinants of mitochondrial dysfunction, including impairment of electron transport chain complex 1, increased oxidative stress, disturbed mitochondrial quality control mechanisms, and cellular bioenergetic deficiency. In addition, we outline mitochondrial pathways to neurodegeneration in the current context of PD pathogenesis, and review past and current treatment strategies in an attempt to better understand why translational efforts thus far have been unsuccessful.
Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial dysfunction, including antioxidants, antidiabetic drugs, and iron chelators, have failed in disease-modification clinical trials. In this review, we summarize the cellular determinants of mitochondrial dysfunction, including impairment of electron transport chain complex 1, increased oxidative stress, disturbed mitochondrial quality control mechanisms, and cellular bioenergetic deficiency. In addition, we outline mitochondrial pathways to neurodegeneration in the current context of PD pathogenesis, and review past and current treatment strategies in an attempt to better understand why translational efforts thus far have been unsuccessful.Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial dysfunction, including antioxidants, antidiabetic drugs, and iron chelators, have failed in disease-modification clinical trials. In this review, we summarize the cellular determinants of mitochondrial dysfunction, including impairment of electron transport chain complex 1, increased oxidative stress, disturbed mitochondrial quality control mechanisms, and cellular bioenergetic deficiency. In addition, we outline mitochondrial pathways to neurodegeneration in the current context of PD pathogenesis, and review past and current treatment strategies in an attempt to better understand why translational efforts thus far have been unsuccessful.
Abstract Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic Parkinson’s disease (PD). However, strategies aimed at ameliorating mitochondrial dysfunction, including antioxidants, antidiabetic drugs, and iron chelators, have failed in disease-modification clinical trials. In this review, we summarize the cellular determinants of mitochondrial dysfunction, including impairment of electron transport chain complex 1, increased oxidative stress, disturbed mitochondrial quality control mechanisms, and cellular bioenergetic deficiency. In addition, we outline mitochondrial pathways to neurodegeneration in the current context of PD pathogenesis, and review past and current treatment strategies in an attempt to better understand why translational efforts thus far have been unsuccessful.
Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial dysfunction, including antioxidants, antidiabetic drugs, and iron chelators, have failed in disease-modification clinical trials. In this review, we summarize the cellular determinants of mitochondrial dysfunction, including impairment of electron transport chain complex 1, increased oxidative stress, disturbed mitochondrial quality control mechanisms, and cellular bioenergetic deficiency. In addition, we outline mitochondrial pathways to neurodegeneration in the current context of PD pathogenesis, and review past and current treatment strategies in an attempt to better understand why translational efforts thus far have been unsuccessful. Keywords: Parkinson's disease, Synuclein, Mitochondria, Mitochondrial dysfunction, MPTP, Electron transport chain, Antioxidants, Neuroprotective therapies
ArticleNumber 83
Audience Academic
Author Henrich, Martin T.
Surmeier, D. James
Oertel, Wolfgang H.
Geibl, Fanni F.
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  fullname: Henrich, Martin T.
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  surname: Geibl
  fullname: Geibl, Fanni F.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37951933$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1212/WNL.98.18_supplement.3068
10.1038/nature14156
10.1371/journal.pone.0039953
10.1371/journal.pone.0131281
10.1038/srep00898
10.1016/S0140-6736(14)61393-3
10.1016/j.nbd.2014.06.017
10.1212/01.wnl.0000250355.28474.8e
10.1016/j.yexcr.2009.09.014
10.1007/s11064-014-1377-0
10.1083/jcb.201807019
10.1073/pnas.1922342117
10.1038/nn.3489
10.1038/s41467-018-03421-7
10.1016/j.nbd.2022.105768
10.1007/s11064-010-0217-0
10.1016/j.brainres.2016.03.001
10.1074/jbc.M113.545749
10.1016/j.stem.2016.08.002
10.1111/jnc.14253
10.1073/pnas.0802076105
10.1016/j.bbadis.2017.07.032
10.1016/j.cub.2011.11.057
10.1038/ncomms6244
10.1016/j.nbd.2011.04.007
10.1038/nature14893
10.1016/j.jns.2021.117412
10.1002/mds.28075
10.1093/brain/115.2.333
10.1016/j.expneurol.2021.113693
10.1126/scitranslmed.aaf3634
10.3389/fcell.2021.636506
10.1038/nm1314
10.1038/s41556-018-0124-1
10.1038/cddis.2015.166
10.3389/fnana.2011.00022
10.1016/j.neuron.2014.12.007
10.1016/j.neulet.2008.05.005
10.1126/science.1227157
10.1016/j.mcn.2014.08.002
10.1073/pnas.0711845105
10.1016/j.stem.2021.02.011
10.1126/science.aag1095
10.1007/s00210-019-01804-1
10.1093/jnen/61.7.634
10.1111/jnc.14810
10.1038/srep36669
10.1038/s41467-018-04422-2
10.1111/jnc.15656
10.1089/ars.2016.6905
10.1073/pnas.1217296110
10.1038/nn.3209
10.1126/science.aat8407
10.1016/j.neurobiolaging.2009.07.010
10.1016/j.ajhg.2011.06.001
10.1001/jama.2021.10207
10.3233/JPD-161040
10.1016/j.molcel.2009.02.013
10.1038/s41582-018-0101-0
10.1038/s41467-023-37815-z
10.1371/journal.pone.0016038
10.1073/pnas.0737556100
10.1002/jnr.24952
10.1016/0006-291X(90)90698-M
10.1016/j.cmet.2022.02.001
10.1038/s41598-020-66493-w
10.1126/science.6823561
10.1002/mds.28850
10.1186/s13024-020-00367-7
10.1093/hmg/ddaa077
10.1126/sciadv.abp8701
10.1016/j.neulet.2009.02.056
10.1212/WNL.0000000000002744
10.1038/s41598-017-07181-0
10.1371/journal.pone.0085815
10.1074/jbc.M109.066662
10.1093/brain/awq051
10.1016/S0896-6273(03)00126-0
10.1097/NEN.0b013e3182269ecd
10.1016/j.neuroscience.2004.06.016
10.3390/antiox12061257
10.1046/j.1471-4159.2003.01533.x
10.1002/ana.20587
10.1126/science.1093891
10.1007/BF01244786
10.1007/s00702-010-0531-3
10.1016/0006-8993(95)01255-9
10.1016/j.cmet.2019.09.001
10.1074/jbc.M401135200
10.1016/j.cub.2015.07.050
10.1038/s41392-022-00933-z
10.1523/JNEUROSCI.1659-16.2016
10.1111/j.1471-4159.2005.03112.x
10.1172/JCI95898
10.1126/sciadv.aba1193
10.1002/cpt.1548
10.1073/pnas.0705363105
10.1002/cpdd.1146
10.1016/j.neuropharm.2023.109652
10.1038/nrn.2016.178
10.1111/j.1471-4159.2007.05097.x
10.1093/hmg/ddv340
10.1016/j.jocn.2022.10.023
10.1186/1750-1326-8-29
10.1016/j.stemcr.2020.07.013
10.1007/s00401-021-02285-4
10.1038/s41582-019-0155-7
10.1371/journal.pone.0012333
10.1002/mds.27193
10.1038/ng1884
10.1016/j.nbd.2005.08.018
10.1038/s41586-020-1968-7
10.1038/nature04779
10.1016/0304-3940(94)90372-7
10.1016/S0002-9440(10)61113-3
10.1002/mds.23148
10.1016/j.neuroscience.2014.05.038
10.1016/j.mcn.2010.12.004
10.1523/JNEUROSCI.2519-09.2009
10.1016/j.neuro.2021.02.002
10.3389/fneur.2018.00455
10.1016/S0896-6273(03)00568-3
10.1101/cshperspect.a009290
10.1016/j.brainres.2018.06.010
10.1093/hmg/ddab057
10.1038/nrdp.2017.13
10.1523/JNEUROSCI.4029-08.2009
10.3233/JPD-2011-11023
10.1007/s00401-017-1794-7
10.1016/S1474-4422(15)00144-1
10.1038/s41582-019-0301-2
10.1001/jamaneurol.2014.131
10.1039/C4MT00326H
10.1016/j.neuropharm.2008.08.033
10.1172/JCI120848
10.1038/s41419-022-04602-5
10.1038/nature04788
10.1016/S0014-4886(03)00342-X
10.3390/cells8090961
10.1111/j.1471-4159.1990.tb04973.x
10.1038/s41586-018-0448-9
10.1016/j.celrep.2015.08.001
10.1002/ana.24346
10.1016/j.ajhg.2011.06.008
10.1002/1873-3468.12964
10.1093/hmg/ddq430
10.1038/s41586-019-1405-y
10.1016/0006-2952(92)90091-V
10.1038/s41598-017-01402-2
10.1111/j.1471-4159.2005.03442.x
10.1073/pnas.0703219104
10.1038/cdd.2017.175
10.1186/1750-1326-7-22
10.1016/j.neulet.2020.135493
10.1083/jcb.201603105
10.1016/S0006-8993(97)01192-X
10.1001/jamaneurol.2013.5528
10.1186/s13024-016-0090-7
10.1126/science.aam9080
10.1242/jcs.078303
10.1038/s41598-019-46120-z
10.1002/ddr.22077
10.1186/s40035-020-00229-8
10.1016/j.tins.2021.12.002
10.1073/pnas.1112368109
10.1242/jcs.258653
10.1016/S0140-6736(21)00218-X
10.1016/S0197-4580(02)00065-9
10.1016/j.celrep.2018.05.009
10.1073/pnas.80.14.4546
10.1016/0006-291X(89)91141-8
10.1016/j.abb.2018.04.018
10.1097/WNF.0000000000000528
10.1371/journal.pbio.0020362
10.1139/G08-085
10.1007/s12033-007-0052-y
10.1016/j.ccr.2005.02.010
10.1007/s12035-014-9043-8
10.1002/emmm.200900006
10.1038/nn.3717
10.1016/j.brainres.2021.147434
10.1016/j.freeradbiomed.2010.08.028
10.2174/1871527314666150821103306
10.1371/journal.pone.0040501
10.1016/j.ajhg.2016.01.014
10.1016/j.nbd.2022.105687
10.1002/mds.28826
10.1073/pnas.0501078102
10.1007/s11481-016-9650-4
10.1038/nature09536
10.1007/s00401-017-1704-z
10.1016/j.pnpbp.2019.109670
10.1007/s12035-022-02897-1
10.1016/S0140-6736(89)92366-0
10.1093/hmg/ddq215
10.1136/bmjopen-2020-047993
10.1093/hmg/ddz241
10.7573/dic.212553
10.1186/s40478-019-0821-4
10.7326/M19-2534
10.1002/jcph.1575
10.3389/fnagi.2021.660843
10.1016/S1474-4422(06)70373-8
10.3389/fneur.2020.592104
10.1083/jcb.202106046
10.1093/brain/awq015
10.1016/0014-5793(92)80118-Z
10.1074/jbc.M710012200
10.1001/archneur.59.10.1541
10.1038/ncomms13548
10.1093/aje/kwr362
10.1186/s13024-021-00501-z
10.1083/jcb.201803152
10.1073/pnas.0803998105
10.1002/mds.22732
10.1016/j.brainresbull.2015.02.007
10.3389/fnins.2022.970925
10.3389/fnmol.2020.00153
10.1111/febs.16099
10.1002/mds.22139
10.1016/0024-3205(85)90146-8
10.1038/s42255-019-0161-5
10.1002/mds.25135
10.1007/s00401-012-1013-5
10.1128/MCB.25.22.10190-10201.2005
10.1007/s10571-020-00849-8
10.1165/rcmb.2015-0304OC
10.1016/j.neulet.2008.09.069
10.1016/j.brainres.2010.02.045
10.1093/brain/awx118
10.1001/jamaneurol.2017.3363
10.1038/cddis.2014.307
10.1038/nm.3983
10.1016/j.stemcr.2017.08.026
10.1371/journal.pone.0009367
10.1093/hmg/ddm083
10.1007/s00401-017-1684-z
10.1038/s41586-021-04059-0
10.1002/mds.27823
10.1093/brain/aww080
10.1007/s00018-017-2541-x
10.1089/ars.2011.4033
10.1016/j.cell.2016.05.039
10.1093/hmg/ddq288
10.1089/ars.2013.5593
10.1006/exnr.2002.8050
10.1111/j.1471-4159.2008.05332.x
10.1159/000103641
10.1016/S0140-6736(17)31585-4
10.1212/WNL.0000000000001905
10.1007/s00726-011-0850-1
10.3389/fcell.2020.615461
10.1002/mds.26424
10.1111/jnc.13731
10.1007/s12640-022-00501-x
10.1046/j.1471-4159.2003.02210.x
10.1111/j.1471-4159.2009.06040.x
10.1073/pnas.1906565116
10.1126/science.1077209
10.1006/exnr.1999.7049
10.1111/j.1471-4159.2012.07734.x
10.1089/ars.2013.5446
10.1016/j.neuint.2016.07.003
10.1212/01.wnl.0000201252.57661.e1
10.1038/nature05865
10.1002/ana.410300409
10.1016/j.neulet.2010.09.061
10.1056/NEJMoa2209254
10.1073/pnas.0602493103
10.1007/s00401-018-1873-4
10.1007/s00401-010-0664-3
10.1074/jbc.M109.061051
10.1038/ng1769
10.1002/ana.21492
10.1074/jbc.M304517200
10.1038/s41467-018-07416-2
10.1016/S0002-9440(10)64553-1
10.1038/nature10992
10.1002/mds.28238
10.1016/j.expneurol.2012.11.007
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Issue 1
Keywords Antioxidants
Electron transport chain
Neuroprotective therapies
Mitochondria
Mitochondrial dysfunction
MPTP
Synuclein
Parkinson’s disease
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License 2023. The Author(s).
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References N Noda (676_CR201) 2022; 11
JN Guzman (676_CR145) 2010; 468
A Singh (676_CR86) 2019; 1702
RH Kim (676_CR147) 2005; 7
IH Flones (676_CR48) 2018; 135
S van Veen (676_CR89) 2020; 578
W Poewe (676_CR3) 2017; 3
MEA El-Shamarka (676_CR228) 2020; 393
H Houlden (676_CR115) 2012; 124
HW Park (676_CR194) 2020; 10
CH Hsieh (676_CR271) 2016; 19
Q Gao (676_CR135) 2022; 7
E Tolosa (676_CR84) 2020; 16
P Klivenyi (676_CR164) 2006; 21
B Pasternak (676_CR283) 2012; 175
V Soubannier (676_CR119) 2012; 22
T Fujii (676_CR90) 2023; 14
T Ozawa (676_CR51) 1990; 172
YT Liu (676_CR107) 2020; 29
L Zhou (676_CR103) 2017; 1863
D Athauda (676_CR260) 2017; 390
A Shtifman (676_CR76) 2011; 32
A Elkouzi (676_CR252) 2019; 15
676_CR146
WJ Nicklas (676_CR37) 1985; 36
676_CR266
A Rahimmi (676_CR214) 2015; 113
TN Martinez (676_CR42) 2012; 16
MH Ludtmann (676_CR64) 2016; 36
AJ Whitworth (676_CR134) 2005; 102
AM Todd (676_CR277) 2008; 51
X Wang (676_CR79) 2012; 121
LK Song (676_CR166) 2015; 10
S Paillusson (676_CR172) 2017; 134
C Cleren (676_CR197) 2008; 104
K Doppler (676_CR9) 2017; 133
B Brakedal (676_CR223) 2022; 34
I Schlesinger (676_CR224) 2008; 23
Y Ruan (676_CR104) 2022; 13
MO Poulter (676_CR208) 2004; 128
RS Akundi (676_CR131) 2011; 6
Y Moon (676_CR193) 2005; 93
676_CR110
LF Burbulla (676_CR153) 2017; 357
S Nath (676_CR184) 2011; 46
TL Lewis Jr (676_CR22) 2018; 9
JC Corona (676_CR264) 2015; 40
S Shendelman (676_CR151) 2004; 2
L Zondler (676_CR152) 2014; 5
D Devos (676_CR250) 2014; 21
R Taipa (676_CR77) 2016; 139
S Bukhatwa (676_CR187) 2010; 1326
D Conze (676_CR221) 2019; 9
S Gandhi (676_CR73) 2009; 33
CE Ellis (676_CR65) 2005; 25
VM Mann (676_CR53) 1992; 299
NF Abdelkader (676_CR233) 2016; 53
MA Schwarzschild (676_CR232) 2021; 326
JW Langston (676_CR34) 1983; 219
JY Han (676_CR185) 1895; 2018
LK Mischley (676_CR213) 2017; 7
L Chen (676_CR256) 2022; 106
J Park (676_CR133) 2006; 441
G Liu (676_CR163) 2009; 454
AY Abramov (676_CR122) 2010; 133
RP Chakrabarty (676_CR19) 2021; 28
M Delgado-Camprubi (676_CR97) 2017; 24
A Martin-Bastida (676_CR249) 2017; 7
A Meister (676_CR211) 1992; 44
CC Stichel (676_CR127) 2007; 16
ME Haque (676_CR274) 2008; 105
F Molina-Holgado (676_CR248) 2008; 105
N Kuhlmann (676_CR81) 2020; 13
MHR Ludtmann (676_CR169) 2018; 9
E Ilijic (676_CR281) 2011; 43
G Krebiehl (676_CR143) 2010; 5
E Chung (676_CR278) 2020; 6
G Aston-Jones (676_CR26) 2016; 1645
A Ghosh (676_CR204) 2010; 49
D Matheoud (676_CR182) 2016; 166
AMA El-Latif (676_CR230) 2023; 84
L Bergkvist (676_CR259) 2021; 341
SJ Lee (676_CR150) 2003; 278
ET Williams (676_CR99) 2022; 170
KR Chaudhuri (676_CR4) 2006; 5
CA Gautier (676_CR128) 2012; 7
JB Spinelli (676_CR18) 2018; 20
V Bonifati (676_CR142) 2003; 299
R Di Maio (676_CR170) 2016; 8
676_CR178
S Lautrup (676_CR218) 2019; 30
K Bahmed (676_CR148) 2016; 55
CA Gautier (676_CR72) 2008; 105
J Arias-Fuenzalida (676_CR61) 2017; 9
MJ LaVoie (676_CR138) 2005; 11
R Dodel (676_CR242) 2010; 25
JY Wang (676_CR244) 2016; 6
A Ghosh (676_CR206) 2016; 11
Investigators (676_CR265) 2015; 14
SR Subramaniam (676_CR62) 2014; 70
SM Fereshtehnejad (676_CR287) 2017; 140
W Dauer (676_CR35) 2003; 39
AK Reeve (676_CR162) 2015; 6
BR Bloem (676_CR1) 2021; 397
MG Schlossmacher (676_CR137) 2002; 160
VS Burchell (676_CR95) 2013; 16
E Katsyuba (676_CR255) 2020; 2
S Dahiya (676_CR257) 2022; 6
S Kim (676_CR188) 1807; 2021
LJ Hsu (676_CR66) 2000; 157
ES Luth (676_CR159) 2014; 289
G Yellen (676_CR17) 2018; 217
G Richarme (676_CR154) 2017; 357
YC Wong (676_CR16) 2019; 34
IE Clark (676_CR71) 2006; 441
S Charisis (676_CR210) 2022; 37
L Li (676_CR60) 2013; 8
D Devos (676_CR251) 2022; 387
VM Mann (676_CR45) 1992; 115
TV Ilic (676_CR191) 1999; 14
JN Guzman (676_CR176) 2018; 128
JN Guzman (676_CR27) 2009; 29
G Raghu (676_CR254) 2021; 19
A Bender (676_CR55) 2006; 38
J Sassone (676_CR98) 2021; 41
P Gonzalez-Rodriguez (676_CR43) 2021; 599
AA Abdin (676_CR195) 2008; 55
J Sanchez-Padilla (676_CR30) 2014; 17
A Zimprich (676_CR157) 2011; 89
N Reich (676_CR258) 2022; 16
W Wang (676_CR101) 2016; 22
M Bian (676_CR276) 2012; 7
W Matsuda (676_CR20) 2009; 29
A Bose (676_CR174) 2016; 139
V Nicoletti (676_CR175) 2021; 9
S Vrijsen (676_CR92) 2020; 117
CW Shults (676_CR198) 2002; 59
DT Dexter (676_CR245) 2011; 118
C Jiang (676_CR235) 2022; 45
AG Sathe (676_CR237) 2020; 60
VA Morais (676_CR130) 2009; 1
P Ge (676_CR67) 2020; 15
ZD Zhou (676_CR96) 2015; 24
A Singh (676_CR282) 2016; 99
DJ Surmeier (676_CR286) 2022; 37
S Joseph (676_CR94) 2018; 144
MX Henderson (676_CR11) 2022; 168
GL McLelland (676_CR120) 2016; 214
EC Hirsch (676_CR14) 2021; 36
D Matheoud (676_CR183) 2019; 571
C Malatt (676_CR262) 2022; 98
DJ Surmeier (676_CR29) 2012; 2
E Giaime (676_CR80) 2012; 7
DG Workman (676_CR247) 2015; 7
C Shan (676_CR219) 2019; 94
N Subrahmanian (676_CR47) 2021; 1767
JM Tokarew (676_CR141) 2021; 141
S Younes-Mhenni (676_CR190) 2007; 58
N Giguere (676_CR12) 2018; 9
L Devi (676_CR59) 2008; 283
Y Yang (676_CR280) 2006; 103
MF Beal (676_CR196) 1998; 783
S Sahoo (676_CR15) 2022; 59
E Andres-Mateos (676_CR144) 2007; 104
CS Chan (676_CR28) 2007; 447
G Gu (676_CR54) 2002; 61
SJ Chinta (676_CR160) 2010; 486
JC Greene (676_CR132) 2003; 100
AP West (676_CR180) 2015; 520
A Negida (676_CR200) 2016; 15
I Kamienieva (676_CR68) 2021; 10
EM Rocha (676_CR83) 2022; 45
H Qi (676_CR236) 2021; 741
T Klopstock (676_CR238) 2011; 40
N Vijiaratnam (676_CR261) 2021; 11
HY Heo (676_CR85) 2010; 316
W Wang (676_CR158) 2017; 26
FL Tang (676_CR102) 2015; 12
GU Hoglinger (676_CR40) 2003; 84
E Zampese (676_CR32) 2022; 8
H Mortiboys (676_CR234) 2015; 85
Y Mizuno (676_CR49) 1989; 163
H Mortiboys (676_CR124) 2008; 64
RB Postuma (676_CR2) 2015; 30
B Dehay (676_CR93) 2012; 109
T Dehmer (676_CR263) 2004; 88
JR Cannon (676_CR167) 2013; 240
JH Martinez (676_CR171) 2018; 651
LV Kalia (676_CR13) 2015; 386
C Martinez-Gonzalez (676_CR25) 2011; 5
J Prasuhn (676_CR202) 2020; 11
D Kaur (676_CR246) 2003; 37
M Periquet (676_CR126) 2005; 95
AH Schapira (676_CR44) 1989; 1
CR Sunico (676_CR140) 2013; 8
P Banerjee (676_CR203) 2022; 40
MA Schwarzschild (676_CR231) 2014; 71
S Khanal (676_CR229) 2023; 238
M Cui (676_CR136) 2010; 285
XL Zhang (676_CR269) 2021; 84
TG Beach (676_CR7) 2010; 119
PR Angelova (676_CR33) 2018; 592
X Chen (676_CR226) 2013; 110
IP Hargreaves (676_CR189) 2008; 447
676_CR215
S Koga (676_CR6) 2021; 16
P Lestienne (676_CR52) 1990; 55
DA Monti (676_CR217) 2019; 106
JP Bolam (676_CR23) 2012; 27
V Loeb (676_CR161) 2010; 285
B Xiao (676_CR87) 2018; 75
Y Yang (676_CR118) 2008; 105
PP Pramstaller (676_CR112) 2005; 58
KS McNaught (676_CR186) 2003; 179
T Oka (676_CR179) 2012; 485
MF Beal (676_CR199) 2014; 71
A Rakovic (676_CR123) 2010; 19
CR Martens (676_CR222) 2018; 9
J Prasuhn (676_CR253) 2020; 8
GE Meredith (676_CR39) 2011; 1
Investigators (676_CR209) 2007; 68
JA Goldberg (676_CR31) 2012; 15
KK Chung (676_CR139) 2004; 304
RZ Fan (676_CR268) 2019; 7
C Vilarino-Guell (676_CR156) 2011; 89
F Pan-Montojo (676_CR41) 2012; 2
N Hattori (676_CR50) 1991; 30
GD Zeevalk (676_CR212) 2010; 35
S Cankaya (676_CR239) 2019; 8
I Irrcher (676_CR78) 2010; 19
BJ Snow (676_CR207) 2010; 25
C Dolle (676_CR56) 2016; 7
M Takanashi (676_CR114) 2016; 86
SA Schneider (676_CR116) 2017; 32
H Braak (676_CR8) 2003; 24
DA Sliter (676_CR181) 2018; 561
M Pinto (676_CR279) 2016; 11
RS Burns (676_CR38) 1983; 80
A Ramirez (676_CR91) 2006; 38
J Cao (676_CR149) 2014; 21
L Bonet-Ponce (676_CR82) 2022; 289
M Kumar (676_CR121) 2020; 15
T Yasuda (676_CR275) 2011; 70
JC Steele (676_CR113) 2015; 77
B Janetzky (676_CR46) 1994; 169
S Bido (676_CR267) 2017; 7
A Ikeda (676_CR106) 2019; 28
AG Erustes (676_CR173) 2021; 99
RT Matthews (676_CR240) 1999; 157
VG Desai (676_CR36) 1996; 715
Investigators (676_CR241) 2006; 66
V Tapias (676_CR63) 2017; 74
DC Schondorf (676_CR220) 2018; 23
S Rahman (676_CR57) 2019; 15
E Area-Gomez (676_CR21) 2019; 129
CH Hsieh (676_CR273) 2019; 30
DD Song (676_CR165) 2004; 186
D Sulzer (676_CR58) 2019; 150
GP Littarru (676_CR192) 2007; 37
M Langley (676_CR205) 2017; 27
J Clark (676_CR216) 2010; 5
AM Pickrell (676_CR69) 2015; 85
MC Mazza (676_CR155) 2022; 162
KJ Thomas (676_CR74) 2011; 20
E Sofic (676_CR243) 1988; 74
YF Tseng (676_CR284) 2021; 424
S Sato (676_CR108) 2021; 30
S Cipriani (676_CR227) 2014; 274
H Deng (676_CR117) 2008; 105
B Heeman (676_CR129) 2011; 124
A Shaltouki (676_CR272) 2018; 136
KC Luk (676_CR10) 2012; 338
Parkinson Study Group S-PDIIII (676_CR285) 2020; 172
R Perfeito (676_CR177) 2014; 62
L Samaranch (676_CR111) 2010; 133
JJ Palacino (676_CR125) 2004; 279
N Kumar (676_CR109) 2018; 217
T Luth (676_CR88) 2020; 35
S Guerreiro (676_CR225) 2009; 109
C Pacelli (676_CR24) 2015; 25
Y Liu (676_CR75) 2019; 116
DJ Surmeier (676_CR5) 2017; 18
M Lazarou (676_CR70) 2015; 524
PM Rappold (676_CR270) 2014; 5
TR Kee (676_CR105) 2021; 13
S Lesage (676_CR100) 2016; 98
S Shavali (676_CR168) 2008; 439
References_xml – volume: 98
  start-page: 3068
  year: 2022
  ident: 676_CR262
  publication-title: Neurology
  doi: 10.1212/WNL.98.18_supplement.3068
– volume: 520
  start-page: 553
  year: 2015
  ident: 676_CR180
  publication-title: Nature
  doi: 10.1038/nature14156
– volume: 7
  start-page: e39953
  year: 2012
  ident: 676_CR276
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0039953
– volume: 10
  start-page: e0131281
  year: 2015
  ident: 676_CR166
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0131281
– volume: 2
  start-page: 898
  year: 2012
  ident: 676_CR41
  publication-title: Sci Rep
  doi: 10.1038/srep00898
– volume: 386
  start-page: 896
  year: 2015
  ident: 676_CR13
  publication-title: Lancet
  doi: 10.1016/S0140-6736(14)61393-3
– volume: 70
  start-page: 204
  year: 2014
  ident: 676_CR62
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2014.06.017
– volume: 68
  start-page: 20
  year: 2007
  ident: 676_CR209
  publication-title: Neurology
  doi: 10.1212/01.wnl.0000250355.28474.8e
– volume: 316
  start-page: 649
  year: 2010
  ident: 676_CR85
  publication-title: Exp Cell Res
  doi: 10.1016/j.yexcr.2009.09.014
– volume: 40
  start-page: 308
  year: 2015
  ident: 676_CR264
  publication-title: Neurochem Res
  doi: 10.1007/s11064-014-1377-0
– volume: 217
  start-page: 3625
  year: 2018
  ident: 676_CR109
  publication-title: J Cell Biol
  doi: 10.1083/jcb.201807019
– volume: 117
  start-page: 31198
  year: 2020
  ident: 676_CR92
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1922342117
– volume: 16
  start-page: 1257
  year: 2013
  ident: 676_CR95
  publication-title: Nat Neurosci
  doi: 10.1038/nn.3489
– volume: 9
  start-page: 1286
  year: 2018
  ident: 676_CR222
  publication-title: Nat Commun
  doi: 10.1038/s41467-018-03421-7
– volume: 170
  start-page: 105768
  year: 2022
  ident: 676_CR99
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2022.105768
– volume: 35
  start-page: 1575
  year: 2010
  ident: 676_CR212
  publication-title: Neurochem Res
  doi: 10.1007/s11064-010-0217-0
– volume: 1645
  start-page: 75
  year: 2016
  ident: 676_CR26
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2016.03.001
– volume: 289
  start-page: 21490
  year: 2014
  ident: 676_CR159
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M113.545749
– volume: 19
  start-page: 709
  year: 2016
  ident: 676_CR271
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2016.08.002
– volume: 144
  start-page: 118
  year: 2018
  ident: 676_CR94
  publication-title: J Neurochem
  doi: 10.1111/jnc.14253
– volume: 105
  start-page: 11364
  year: 2008
  ident: 676_CR72
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0802076105
– volume: 1863
  start-page: 2791
  year: 2017
  ident: 676_CR103
  publication-title: Biochim Biophys Acta Mol basis Dis
  doi: 10.1016/j.bbadis.2017.07.032
– volume: 22
  start-page: 135
  year: 2012
  ident: 676_CR119
  publication-title: Curr Biol
  doi: 10.1016/j.cub.2011.11.057
– volume: 5
  start-page: 5244
  year: 2014
  ident: 676_CR270
  publication-title: Nat Commun
  doi: 10.1038/ncomms6244
– volume: 43
  start-page: 364
  year: 2011
  ident: 676_CR281
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2011.04.007
– volume: 524
  start-page: 309
  year: 2015
  ident: 676_CR70
  publication-title: Nature
  doi: 10.1038/nature14893
– volume: 424
  start-page: 117412
  year: 2021
  ident: 676_CR284
  publication-title: J Neurol Sci
  doi: 10.1016/j.jns.2021.117412
– volume: 36
  start-page: 16
  year: 2021
  ident: 676_CR14
  publication-title: Mov Disord
  doi: 10.1002/mds.28075
– volume: 115
  start-page: 333
  issue: Pt 2
  year: 1992
  ident: 676_CR45
  publication-title: Brain
  doi: 10.1093/brain/115.2.333
– volume: 341
  start-page: 113693
  year: 2021
  ident: 676_CR259
  publication-title: Exp Neurol
  doi: 10.1016/j.expneurol.2021.113693
– volume: 8
  start-page: 342ra378
  year: 2016
  ident: 676_CR170
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.aaf3634
– volume: 9
  start-page: 636506
  year: 2021
  ident: 676_CR175
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2021.636506
– volume: 11
  start-page: 1214
  year: 2005
  ident: 676_CR138
  publication-title: Nat Med
  doi: 10.1038/nm1314
– volume: 20
  start-page: 745
  year: 2018
  ident: 676_CR18
  publication-title: Nat Cell Biol
  doi: 10.1038/s41556-018-0124-1
– volume: 6
  start-page: e1820
  year: 2015
  ident: 676_CR162
  publication-title: Cell Death Dis
  doi: 10.1038/cddis.2015.166
– volume: 5
  start-page: 22
  year: 2011
  ident: 676_CR25
  publication-title: Front Neuroanat
  doi: 10.3389/fnana.2011.00022
– volume: 85
  start-page: 257
  year: 2015
  ident: 676_CR69
  publication-title: Neuron
  doi: 10.1016/j.neuron.2014.12.007
– volume: 439
  start-page: 125
  year: 2008
  ident: 676_CR168
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2008.05.005
– volume: 338
  start-page: 949
  year: 2012
  ident: 676_CR10
  publication-title: Science
  doi: 10.1126/science.1227157
– volume: 62
  start-page: 51
  year: 2014
  ident: 676_CR177
  publication-title: Mol Cell Neurosci
  doi: 10.1016/j.mcn.2014.08.002
– volume: 105
  start-page: 7070
  year: 2008
  ident: 676_CR118
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0711845105
– volume: 28
  start-page: 394
  year: 2021
  ident: 676_CR19
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2021.02.011
– volume: 357
  start-page: 208
  year: 2017
  ident: 676_CR154
  publication-title: Science
  doi: 10.1126/science.aag1095
– volume: 393
  start-page: 1041
  year: 2020
  ident: 676_CR228
  publication-title: Naunyn Schmiedeberg's Arch Pharmacol
  doi: 10.1007/s00210-019-01804-1
– volume: 61
  start-page: 634
  year: 2002
  ident: 676_CR54
  publication-title: J Neuropathol Exp Neurol
  doi: 10.1093/jnen/61.7.634
– volume: 150
  start-page: 475
  year: 2019
  ident: 676_CR58
  publication-title: J Neurochem
  doi: 10.1111/jnc.14810
– volume: 6
  start-page: 36669
  year: 2016
  ident: 676_CR244
  publication-title: Sci Rep
  doi: 10.1038/srep36669
– volume: 9
  start-page: 2293
  year: 2018
  ident: 676_CR169
  publication-title: Nat Commun
  doi: 10.1038/s41467-018-04422-2
– volume: 162
  start-page: 245
  year: 2022
  ident: 676_CR155
  publication-title: J Neurochem
  doi: 10.1111/jnc.15656
– volume: 27
  start-page: 1048
  year: 2017
  ident: 676_CR205
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2016.6905
– volume: 110
  start-page: 300
  year: 2013
  ident: 676_CR226
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1217296110
– volume: 15
  start-page: 1414
  year: 2012
  ident: 676_CR31
  publication-title: Nat Neurosci
  doi: 10.1038/nn.3209
– ident: 676_CR178
  doi: 10.1126/science.aat8407
– volume: 32
  start-page: 125
  year: 2011
  ident: 676_CR76
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2009.07.010
– volume: 89
  start-page: 162
  year: 2011
  ident: 676_CR156
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2011.06.001
– volume: 326
  start-page: 926
  year: 2021
  ident: 676_CR232
  publication-title: JAMA
  doi: 10.1001/jama.2021.10207
– volume: 7
  start-page: 289
  year: 2017
  ident: 676_CR213
  publication-title: J Parkinsons Dis
  doi: 10.3233/JPD-161040
– volume: 33
  start-page: 627
  year: 2009
  ident: 676_CR73
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2009.02.013
– volume: 15
  start-page: 40
  year: 2019
  ident: 676_CR57
  publication-title: Nat Rev Neurol
  doi: 10.1038/s41582-018-0101-0
– volume: 14
  start-page: 2174
  year: 2023
  ident: 676_CR90
  publication-title: Nat Commun
  doi: 10.1038/s41467-023-37815-z
– volume: 6
  start-page: e16038
  year: 2011
  ident: 676_CR131
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0016038
– volume: 100
  start-page: 4078
  year: 2003
  ident: 676_CR132
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0737556100
– volume: 99
  start-page: 2932
  year: 2021
  ident: 676_CR173
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.24952
– volume: 172
  start-page: 483
  year: 1990
  ident: 676_CR51
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/0006-291X(90)90698-M
– volume: 34
  start-page: e396
  issue: 396–407
  year: 2022
  ident: 676_CR223
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2022.02.001
– volume: 10
  start-page: 9572
  year: 2020
  ident: 676_CR194
  publication-title: Sci Rep
  doi: 10.1038/s41598-020-66493-w
– volume: 219
  start-page: 979
  year: 1983
  ident: 676_CR34
  publication-title: Science
  doi: 10.1126/science.6823561
– volume: 37
  start-page: 334
  year: 2022
  ident: 676_CR286
  publication-title: Mov Disord
  doi: 10.1002/mds.28850
– volume: 15
  start-page: 20
  year: 2020
  ident: 676_CR67
  publication-title: Mol Neurodegener
  doi: 10.1186/s13024-020-00367-7
– volume: 29
  start-page: 1547
  year: 2020
  ident: 676_CR107
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddaa077
– volume: 8
  start-page: eabp8701
  year: 2022
  ident: 676_CR32
  publication-title: Sci Adv
  doi: 10.1126/sciadv.abp8701
– volume: 454
  start-page: 187
  year: 2009
  ident: 676_CR163
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2009.02.056
– volume: 86
  start-page: 2212
  year: 2016
  ident: 676_CR114
  publication-title: Neurology
  doi: 10.1212/WNL.0000000000002744
– volume: 7
  start-page: 7495
  year: 2017
  ident: 676_CR267
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-07181-0
– volume: 8
  start-page: e85815
  year: 2013
  ident: 676_CR60
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0085815
– volume: 285
  start-page: 11740
  year: 2010
  ident: 676_CR136
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M109.066662
– volume: 30
  start-page: e1137
  issue: 1131–1140
  year: 2019
  ident: 676_CR273
  publication-title: Cell Metab
– volume: 133
  start-page: 1128
  year: 2010
  ident: 676_CR111
  publication-title: Brain
  doi: 10.1093/brain/awq051
– volume: 37
  start-page: 899
  year: 2003
  ident: 676_CR246
  publication-title: Neuron
  doi: 10.1016/S0896-6273(03)00126-0
– volume: 70
  start-page: 686
  year: 2011
  ident: 676_CR275
  publication-title: J Neuropathol Exp Neurol
  doi: 10.1097/NEN.0b013e3182269ecd
– volume: 128
  start-page: 1
  year: 2004
  ident: 676_CR208
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2004.06.016
– ident: 676_CR215
  doi: 10.3390/antiox12061257
– volume: 84
  start-page: 491
  year: 2003
  ident: 676_CR40
  publication-title: J Neurochem
  doi: 10.1046/j.1471-4159.2003.01533.x
– volume: 58
  start-page: 411
  year: 2005
  ident: 676_CR112
  publication-title: Ann Neurol
  doi: 10.1002/ana.20587
– volume: 304
  start-page: 1328
  year: 2004
  ident: 676_CR139
  publication-title: Science
  doi: 10.1126/science.1093891
– volume: 74
  start-page: 199
  year: 1988
  ident: 676_CR243
  publication-title: J Neural Transm
  doi: 10.1007/BF01244786
– volume: 118
  start-page: 223
  year: 2011
  ident: 676_CR245
  publication-title: J Neural Transm (Vienna)
  doi: 10.1007/s00702-010-0531-3
– volume: 715
  start-page: 1
  year: 1996
  ident: 676_CR36
  publication-title: Brain Res
  doi: 10.1016/0006-8993(95)01255-9
– volume: 6
  start-page: 100133
  year: 2022
  ident: 676_CR257
  publication-title: Clin Park Relat Disord
– volume: 30
  start-page: 630
  year: 2019
  ident: 676_CR218
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2019.09.001
– volume: 279
  start-page: 18614
  year: 2004
  ident: 676_CR125
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M401135200
– volume: 25
  start-page: 2349
  year: 2015
  ident: 676_CR24
  publication-title: Curr Biol
  doi: 10.1016/j.cub.2015.07.050
– volume: 7
  start-page: 103
  year: 2022
  ident: 676_CR135
  publication-title: Signal Transduct Target Ther
  doi: 10.1038/s41392-022-00933-z
– volume: 36
  start-page: 10510
  year: 2016
  ident: 676_CR64
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.1659-16.2016
– volume: 93
  start-page: 1199
  year: 2005
  ident: 676_CR193
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.2005.03112.x
– volume: 128
  start-page: 2266
  year: 2018
  ident: 676_CR176
  publication-title: J Clin Invest
  doi: 10.1172/JCI95898
– volume: 6
  start-page: eaba1193
  year: 2020
  ident: 676_CR278
  publication-title: Sci Adv
  doi: 10.1126/sciadv.aba1193
– volume: 106
  start-page: 884
  year: 2019
  ident: 676_CR217
  publication-title: Clin Pharmacol Ther
  doi: 10.1002/cpt.1548
– volume: 105
  start-page: 1716
  year: 2008
  ident: 676_CR274
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0705363105
– volume: 11
  start-page: 1136
  year: 2022
  ident: 676_CR201
  publication-title: Clin Pharmacol Drug Dev
  doi: 10.1002/cpdd.1146
– volume: 238
  start-page: 109652
  year: 2023
  ident: 676_CR229
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2023.109652
– volume: 18
  start-page: 101
  year: 2017
  ident: 676_CR5
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn.2016.178
– volume: 104
  start-page: 1613
  year: 2008
  ident: 676_CR197
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.2007.05097.x
– volume: 24
  start-page: 6314
  year: 2015
  ident: 676_CR96
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddv340
– volume: 106
  start-page: 154
  year: 2022
  ident: 676_CR256
  publication-title: J Clin Neurosci
  doi: 10.1016/j.jocn.2022.10.023
– volume: 8
  start-page: 29
  year: 2013
  ident: 676_CR140
  publication-title: Mol Neurodegener
  doi: 10.1186/1750-1326-8-29
– volume: 15
  start-page: 629
  year: 2020
  ident: 676_CR121
  publication-title: Stem Cell Rep
  doi: 10.1016/j.stemcr.2020.07.013
– volume: 141
  start-page: 725
  year: 2021
  ident: 676_CR141
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-021-02285-4
– volume: 15
  start-page: 204
  year: 2019
  ident: 676_CR252
  publication-title: Nat Rev Neurol
  doi: 10.1038/s41582-019-0155-7
– volume: 5
  start-page: e12333
  year: 2010
  ident: 676_CR216
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0012333
– volume: 32
  start-page: 1504
  year: 2017
  ident: 676_CR116
  publication-title: Mov Disord
  doi: 10.1002/mds.27193
– volume: 38
  start-page: 1184
  year: 2006
  ident: 676_CR91
  publication-title: Nat Genet
  doi: 10.1038/ng1884
– volume: 21
  start-page: 541
  year: 2006
  ident: 676_CR164
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2005.08.018
– volume: 578
  start-page: 419
  year: 2020
  ident: 676_CR89
  publication-title: Nature
  doi: 10.1038/s41586-020-1968-7
– volume: 441
  start-page: 1162
  year: 2006
  ident: 676_CR71
  publication-title: Nature
  doi: 10.1038/nature04779
– volume: 169
  start-page: 126
  year: 1994
  ident: 676_CR46
  publication-title: Neurosci Lett
  doi: 10.1016/0304-3940(94)90372-7
– volume: 160
  start-page: 1655
  year: 2002
  ident: 676_CR137
  publication-title: Am J Pathol
  doi: 10.1016/S0002-9440(10)61113-3
– volume: 25
  start-page: 1670
  year: 2010
  ident: 676_CR207
  publication-title: Mov Disord
  doi: 10.1002/mds.23148
– volume: 274
  start-page: 242
  year: 2014
  ident: 676_CR227
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2014.05.038
– volume: 46
  start-page: 516
  year: 2011
  ident: 676_CR184
  publication-title: Mol Cell Neurosci
  doi: 10.1016/j.mcn.2010.12.004
– volume: 29
  start-page: 11011
  year: 2009
  ident: 676_CR27
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2519-09.2009
– volume: 84
  start-page: 1
  year: 2021
  ident: 676_CR269
  publication-title: Neurotoxicology
  doi: 10.1016/j.neuro.2021.02.002
– volume: 9
  start-page: 455
  year: 2018
  ident: 676_CR12
  publication-title: Front Neurol
  doi: 10.3389/fneur.2018.00455
– volume: 39
  start-page: 889
  year: 2003
  ident: 676_CR35
  publication-title: Neuron
  doi: 10.1016/S0896-6273(03)00568-3
– volume: 2
  start-page: a009290
  year: 2012
  ident: 676_CR29
  publication-title: Cold Spring Harb Perspect Med
  doi: 10.1101/cshperspect.a009290
– volume: 1702
  start-page: 96
  year: 2019
  ident: 676_CR86
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2018.06.010
– volume: 30
  start-page: 443
  year: 2021
  ident: 676_CR108
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddab057
– volume: 3
  start-page: 17013
  year: 2017
  ident: 676_CR3
  publication-title: Nat Rev Dis Primers
  doi: 10.1038/nrdp.2017.13
– volume: 29
  start-page: 444
  year: 2009
  ident: 676_CR20
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.4029-08.2009
– volume: 1
  start-page: 19
  year: 2011
  ident: 676_CR39
  publication-title: J Parkinsons Dis
  doi: 10.3233/JPD-2011-11023
– volume: 135
  start-page: 409
  year: 2018
  ident: 676_CR48
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-017-1794-7
– volume: 14
  start-page: 795
  year: 2015
  ident: 676_CR265
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(15)00144-1
– volume: 16
  start-page: 97
  year: 2020
  ident: 676_CR84
  publication-title: Nat Rev Neurol
  doi: 10.1038/s41582-019-0301-2
– volume: 71
  start-page: 543
  year: 2014
  ident: 676_CR199
  publication-title: JAMA Neurol
  doi: 10.1001/jamaneurol.2014.131
– volume: 7
  start-page: 867
  year: 2015
  ident: 676_CR247
  publication-title: Metallomics
  doi: 10.1039/C4MT00326H
– volume: 55
  start-page: 1340
  year: 2008
  ident: 676_CR195
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2008.08.033
– volume: 129
  start-page: 34
  year: 2019
  ident: 676_CR21
  publication-title: J Clin Invest
  doi: 10.1172/JCI120848
– volume: 13
  start-page: 156
  year: 2022
  ident: 676_CR104
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-022-04602-5
– volume: 441
  start-page: 1157
  year: 2006
  ident: 676_CR133
  publication-title: Nature
  doi: 10.1038/nature04788
– volume: 186
  start-page: 158
  year: 2004
  ident: 676_CR165
  publication-title: Exp Neurol
  doi: 10.1016/S0014-4886(03)00342-X
– ident: 676_CR266
  doi: 10.3390/cells8090961
– volume: 55
  start-page: 1810
  year: 1990
  ident: 676_CR52
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.1990.tb04973.x
– volume: 561
  start-page: 258
  year: 2018
  ident: 676_CR181
  publication-title: Nature
  doi: 10.1038/s41586-018-0448-9
– volume: 12
  start-page: 1631
  year: 2015
  ident: 676_CR102
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2015.08.001
– volume: 77
  start-page: 458
  year: 2015
  ident: 676_CR113
  publication-title: Ann Neurol
  doi: 10.1002/ana.24346
– volume: 89
  start-page: 168
  year: 2011
  ident: 676_CR157
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2011.06.008
– volume: 592
  start-page: 692
  year: 2018
  ident: 676_CR33
  publication-title: FEBS Lett
  doi: 10.1002/1873-3468.12964
– volume: 20
  start-page: 40
  year: 2011
  ident: 676_CR74
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddq430
– volume: 571
  start-page: 565
  year: 2019
  ident: 676_CR183
  publication-title: Nature
  doi: 10.1038/s41586-019-1405-y
– volume: 44
  start-page: 1905
  year: 1992
  ident: 676_CR211
  publication-title: Biochem Pharmacol
  doi: 10.1016/0006-2952(92)90091-V
– volume: 7
  start-page: 1398
  year: 2017
  ident: 676_CR249
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-01402-2
– volume: 95
  start-page: 1259
  year: 2005
  ident: 676_CR126
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.2005.03442.x
– volume: 104
  start-page: 14807
  year: 2007
  ident: 676_CR144
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0703219104
– volume: 24
  start-page: 2210
  year: 2017
  ident: 676_CR97
  publication-title: Cell Death Differ
  doi: 10.1038/cdd.2017.175
– volume: 7
  start-page: 22
  year: 2012
  ident: 676_CR128
  publication-title: Mol Neurodegener
  doi: 10.1186/1750-1326-7-22
– volume: 741
  start-page: 135493
  year: 2021
  ident: 676_CR236
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2020.135493
– volume: 214
  start-page: 275
  year: 2016
  ident: 676_CR120
  publication-title: J Cell Biol
  doi: 10.1083/jcb.201603105
– volume: 783
  start-page: 109
  year: 1998
  ident: 676_CR196
  publication-title: Brain Res
  doi: 10.1016/S0006-8993(97)01192-X
– volume: 71
  start-page: 141
  year: 2014
  ident: 676_CR231
  publication-title: JAMA Neurol
  doi: 10.1001/jamaneurol.2013.5528
– volume: 11
  start-page: 25
  year: 2016
  ident: 676_CR279
  publication-title: Mol Neurodegener
  doi: 10.1186/s13024-016-0090-7
– volume: 357
  start-page: 1255
  year: 2017
  ident: 676_CR153
  publication-title: Science
  doi: 10.1126/science.aam9080
– volume: 14
  start-page: 141
  year: 1999
  ident: 676_CR191
  publication-title: Funct Neurol
– volume: 124
  start-page: 1115
  year: 2011
  ident: 676_CR129
  publication-title: J Cell Sci
  doi: 10.1242/jcs.078303
– volume: 9
  start-page: 9772
  year: 2019
  ident: 676_CR221
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-46120-z
– volume: 84
  start-page: 1159
  year: 2023
  ident: 676_CR230
  publication-title: Drug Dev Res
  doi: 10.1002/ddr.22077
– volume: 10
  start-page: 5
  year: 2021
  ident: 676_CR68
  publication-title: Transl Neurodegener
  doi: 10.1186/s40035-020-00229-8
– volume: 45
  start-page: 224
  year: 2022
  ident: 676_CR83
  publication-title: Trends Neurosci
  doi: 10.1016/j.tins.2021.12.002
– volume: 109
  start-page: 9611
  year: 2012
  ident: 676_CR93
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1112368109
– ident: 676_CR146
  doi: 10.1242/jcs.258653
– volume: 397
  start-page: 2284
  year: 2021
  ident: 676_CR1
  publication-title: Lancet
  doi: 10.1016/S0140-6736(21)00218-X
– volume: 24
  start-page: 197
  year: 2003
  ident: 676_CR8
  publication-title: Neurobiol Aging
  doi: 10.1016/S0197-4580(02)00065-9
– volume: 26
  start-page: 781
  year: 2017
  ident: 676_CR158
  publication-title: Hum Mol Genet
– volume: 23
  start-page: 2976
  year: 2018
  ident: 676_CR220
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2018.05.009
– volume: 80
  start-page: 4546
  year: 1983
  ident: 676_CR38
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.80.14.4546
– volume: 163
  start-page: 1450
  year: 1989
  ident: 676_CR49
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/0006-291X(89)91141-8
– volume: 651
  start-page: 1
  year: 2018
  ident: 676_CR171
  publication-title: Arch Biochem Biophys
  doi: 10.1016/j.abb.2018.04.018
– volume: 45
  start-page: 168
  year: 2022
  ident: 676_CR235
  publication-title: Clin Neuropharmacol
  doi: 10.1097/WNF.0000000000000528
– volume: 2
  start-page: e362
  year: 2004
  ident: 676_CR151
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.0020362
– volume: 51
  start-page: 1040
  year: 2008
  ident: 676_CR277
  publication-title: Genome
  doi: 10.1139/G08-085
– volume: 37
  start-page: 31
  year: 2007
  ident: 676_CR192
  publication-title: Mol Biotechnol
  doi: 10.1007/s12033-007-0052-y
– volume: 7
  start-page: 263
  year: 2005
  ident: 676_CR147
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2005.02.010
– volume: 53
  start-page: 810
  year: 2016
  ident: 676_CR233
  publication-title: Mol Neurobiol
  doi: 10.1007/s12035-014-9043-8
– volume: 1
  start-page: 99
  year: 2009
  ident: 676_CR130
  publication-title: EMBO Mol Med
  doi: 10.1002/emmm.200900006
– volume: 17
  start-page: 832
  year: 2014
  ident: 676_CR30
  publication-title: Nat Neurosci
  doi: 10.1038/nn.3717
– volume: 1767
  start-page: 147434
  year: 2021
  ident: 676_CR47
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2021.147434
– volume: 49
  start-page: 1674
  year: 2010
  ident: 676_CR204
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2010.08.028
– volume: 15
  start-page: 45
  year: 2016
  ident: 676_CR200
  publication-title: CNS Neurol Disord Drug Targets
  doi: 10.2174/1871527314666150821103306
– volume: 7
  start-page: e40501
  year: 2012
  ident: 676_CR80
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0040501
– volume: 98
  start-page: 500
  year: 2016
  ident: 676_CR100
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2016.01.014
– volume: 168
  start-page: 105687
  year: 2022
  ident: 676_CR11
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2022.105687
– volume: 37
  start-page: 200
  year: 2022
  ident: 676_CR210
  publication-title: Mov Disord
  doi: 10.1002/mds.28826
– volume: 102
  start-page: 8024
  year: 2005
  ident: 676_CR134
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0501078102
– volume: 11
  start-page: 259
  year: 2016
  ident: 676_CR206
  publication-title: J NeuroImmune Pharmacol
  doi: 10.1007/s11481-016-9650-4
– volume: 468
  start-page: 696
  year: 2010
  ident: 676_CR145
  publication-title: Nature
  doi: 10.1038/nature09536
– volume: 134
  start-page: 129
  year: 2017
  ident: 676_CR172
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-017-1704-z
– volume: 94
  start-page: 109670
  year: 2019
  ident: 676_CR219
  publication-title: Prog Neuro-Psychopharmacol Biol Psychiatry
  doi: 10.1016/j.pnpbp.2019.109670
– volume: 59
  start-page: 5379
  year: 2022
  ident: 676_CR15
  publication-title: Mol Neurobiol
  doi: 10.1007/s12035-022-02897-1
– volume: 1
  start-page: 1269
  year: 1989
  ident: 676_CR44
  publication-title: Lancet
  doi: 10.1016/S0140-6736(89)92366-0
– volume: 19
  start-page: 3124
  year: 2010
  ident: 676_CR123
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddq215
– volume: 11
  start-page: e047993
  year: 2021
  ident: 676_CR261
  publication-title: BMJ Open
  doi: 10.1136/bmjopen-2020-047993
– volume: 28
  start-page: 3895
  year: 2019
  ident: 676_CR106
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddz241
– volume: 8
  start-page: 212553
  year: 2019
  ident: 676_CR239
  publication-title: Drugs Context
  doi: 10.7573/dic.212553
– volume: 7
  start-page: 184
  year: 2019
  ident: 676_CR268
  publication-title: Acta Neuropathol Commun
  doi: 10.1186/s40478-019-0821-4
– volume: 172
  start-page: 591
  year: 2020
  ident: 676_CR285
  publication-title: Ann Intern Med
  doi: 10.7326/M19-2534
– volume: 2021
  start-page: 12
  year: 1807
  ident: 676_CR188
  publication-title: Nat Commun
– volume: 60
  start-page: 744
  year: 2020
  ident: 676_CR237
  publication-title: J Clin Pharmacol
  doi: 10.1002/jcph.1575
– volume: 13
  start-page: 660843
  year: 2021
  ident: 676_CR105
  publication-title: Front Aging Neurosci
  doi: 10.3389/fnagi.2021.660843
– volume: 5
  start-page: 235
  year: 2006
  ident: 676_CR4
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(06)70373-8
– volume: 11
  start-page: 592104
  year: 2020
  ident: 676_CR202
  publication-title: Front Neurol
  doi: 10.3389/fneur.2020.592104
– volume: 19
  start-page: 1202
  year: 2021
  ident: 676_CR254
  publication-title: Curr Neuropharmacol
– ident: 676_CR110
  doi: 10.1083/jcb.202106046
– volume: 133
  start-page: 797
  year: 2010
  ident: 676_CR122
  publication-title: Brain
  doi: 10.1093/brain/awq015
– volume: 299
  start-page: 218
  year: 1992
  ident: 676_CR53
  publication-title: FEBS Lett
  doi: 10.1016/0014-5793(92)80118-Z
– volume: 283
  start-page: 9089
  year: 2008
  ident: 676_CR59
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M710012200
– volume: 59
  start-page: 1541
  year: 2002
  ident: 676_CR198
  publication-title: Arch Neurol
  doi: 10.1001/archneur.59.10.1541
– volume: 7
  start-page: 13548
  year: 2016
  ident: 676_CR56
  publication-title: Nat Commun
  doi: 10.1038/ncomms13548
– volume: 175
  start-page: 627
  year: 2012
  ident: 676_CR283
  publication-title: Am J Epidemiol
  doi: 10.1093/aje/kwr362
– volume: 16
  start-page: 83
  year: 2021
  ident: 676_CR6
  publication-title: Mol Neurodegener
  doi: 10.1186/s13024-021-00501-z
– volume: 217
  start-page: 2235
  year: 2018
  ident: 676_CR17
  publication-title: J Cell Biol
  doi: 10.1083/jcb.201803152
– volume: 105
  start-page: 14503
  year: 2008
  ident: 676_CR117
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0803998105
– volume: 25
  start-page: 97
  year: 2010
  ident: 676_CR242
  publication-title: Mov Disord
  doi: 10.1002/mds.22732
– volume: 113
  start-page: 34
  year: 2015
  ident: 676_CR214
  publication-title: Brain Res Bull
  doi: 10.1016/j.brainresbull.2015.02.007
– volume: 16
  start-page: 970925
  year: 2022
  ident: 676_CR258
  publication-title: Front Neurosci
  doi: 10.3389/fnins.2022.970925
– volume: 13
  start-page: 153
  year: 2020
  ident: 676_CR81
  publication-title: Front Mol Neurosci
  doi: 10.3389/fnmol.2020.00153
– volume: 289
  start-page: 6871
  year: 2022
  ident: 676_CR82
  publication-title: FEBS J
  doi: 10.1111/febs.16099
– volume: 23
  start-page: 1653
  year: 2008
  ident: 676_CR224
  publication-title: Mov Disord
  doi: 10.1002/mds.22139
– volume: 36
  start-page: 2503
  year: 1985
  ident: 676_CR37
  publication-title: Life Sci
  doi: 10.1016/0024-3205(85)90146-8
– volume: 2
  start-page: 9
  year: 2020
  ident: 676_CR255
  publication-title: Nat Metab
  doi: 10.1038/s42255-019-0161-5
– volume: 27
  start-page: 1478
  year: 2012
  ident: 676_CR23
  publication-title: Mov Disord
  doi: 10.1002/mds.25135
– volume: 124
  start-page: 325
  year: 2012
  ident: 676_CR115
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-012-1013-5
– volume: 25
  start-page: 10190
  year: 2005
  ident: 676_CR65
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.25.22.10190-10201.2005
– volume: 41
  start-page: 199
  year: 2021
  ident: 676_CR98
  publication-title: Cell Mol Neurobiol
  doi: 10.1007/s10571-020-00849-8
– volume: 2018
  start-page: 8
  year: 1895
  ident: 676_CR185
  publication-title: Sci Rep
– volume: 55
  start-page: 439
  year: 2016
  ident: 676_CR148
  publication-title: Am J Respir Cell Mol Biol
  doi: 10.1165/rcmb.2015-0304OC
– volume: 447
  start-page: 17
  year: 2008
  ident: 676_CR189
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2008.09.069
– volume: 1326
  start-page: 174
  year: 2010
  ident: 676_CR187
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2010.02.045
– volume: 140
  start-page: 1959
  year: 2017
  ident: 676_CR287
  publication-title: Brain
  doi: 10.1093/brain/awx118
– volume: 75
  start-page: 127
  year: 2018
  ident: 676_CR87
  publication-title: JAMA Neurol
  doi: 10.1001/jamaneurol.2017.3363
– volume: 5
  start-page: e1350
  year: 2014
  ident: 676_CR152
  publication-title: Cell Death Dis
  doi: 10.1038/cddis.2014.307
– volume: 22
  start-page: 54
  year: 2016
  ident: 676_CR101
  publication-title: Nat Med
  doi: 10.1038/nm.3983
– volume: 9
  start-page: 1423
  year: 2017
  ident: 676_CR61
  publication-title: Stem Cell Rep
  doi: 10.1016/j.stemcr.2017.08.026
– volume: 5
  start-page: e9367
  year: 2010
  ident: 676_CR143
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0009367
– volume: 16
  start-page: 2377
  year: 2007
  ident: 676_CR127
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddm083
– volume: 133
  start-page: 535
  year: 2017
  ident: 676_CR9
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-017-1684-z
– volume: 599
  start-page: 650
  year: 2021
  ident: 676_CR43
  publication-title: Nature
  doi: 10.1038/s41586-021-04059-0
– volume: 34
  start-page: 1406
  year: 2019
  ident: 676_CR16
  publication-title: Mov Disord
  doi: 10.1002/mds.27823
– volume: 139
  start-page: 1680
  year: 2016
  ident: 676_CR77
  publication-title: Brain
  doi: 10.1093/brain/aww080
– volume: 74
  start-page: 2851
  year: 2017
  ident: 676_CR63
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s00018-017-2541-x
– volume: 16
  start-page: 920
  year: 2012
  ident: 676_CR42
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2011.4033
– volume: 166
  start-page: 314
  year: 2016
  ident: 676_CR182
  publication-title: Cell
  doi: 10.1016/j.cell.2016.05.039
– volume: 19
  start-page: 3734
  year: 2010
  ident: 676_CR78
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddq288
– volume: 21
  start-page: 195
  year: 2014
  ident: 676_CR250
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2013.5593
– volume: 179
  start-page: 38
  year: 2003
  ident: 676_CR186
  publication-title: Exp Neurol
  doi: 10.1006/exnr.2002.8050
– volume: 105
  start-page: 2466
  year: 2008
  ident: 676_CR248
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.2008.05332.x
– volume: 58
  start-page: 78
  year: 2007
  ident: 676_CR190
  publication-title: Eur Neurol
  doi: 10.1159/000103641
– volume: 390
  start-page: 1664
  year: 2017
  ident: 676_CR260
  publication-title: Lancet
  doi: 10.1016/S0140-6736(17)31585-4
– volume: 85
  start-page: 846
  year: 2015
  ident: 676_CR234
  publication-title: Neurology
  doi: 10.1212/WNL.0000000000001905
– volume: 40
  start-page: 1297
  year: 2011
  ident: 676_CR238
  publication-title: Amino Acids
  doi: 10.1007/s00726-011-0850-1
– volume: 8
  start-page: 615461
  year: 2020
  ident: 676_CR253
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2020.615461
– volume: 30
  start-page: 1591
  year: 2015
  ident: 676_CR2
  publication-title: Mov Disord
  doi: 10.1002/mds.26424
– volume: 139
  start-page: 216
  issue: Suppl 1
  year: 2016
  ident: 676_CR174
  publication-title: J Neurochem
  doi: 10.1111/jnc.13731
– volume: 40
  start-page: 847
  year: 2022
  ident: 676_CR203
  publication-title: Neurotox Res
  doi: 10.1007/s12640-022-00501-x
– volume: 88
  start-page: 494
  year: 2004
  ident: 676_CR263
  publication-title: J Neurochem
  doi: 10.1046/j.1471-4159.2003.02210.x
– volume: 109
  start-page: 1118
  year: 2009
  ident: 676_CR225
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.2009.06040.x
– volume: 116
  start-page: 25322
  year: 2019
  ident: 676_CR75
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1906565116
– volume: 299
  start-page: 256
  year: 2003
  ident: 676_CR142
  publication-title: Science
  doi: 10.1126/science.1077209
– volume: 157
  start-page: 142
  year: 1999
  ident: 676_CR240
  publication-title: Exp Neurol
  doi: 10.1006/exnr.1999.7049
– volume: 121
  start-page: 830
  year: 2012
  ident: 676_CR79
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.2012.07734.x
– volume: 21
  start-page: 1443
  year: 2014
  ident: 676_CR149
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2013.5446
– volume: 99
  start-page: 221
  year: 2016
  ident: 676_CR282
  publication-title: Neurochem Int
  doi: 10.1016/j.neuint.2016.07.003
– volume: 66
  start-page: 664
  year: 2006
  ident: 676_CR241
  publication-title: Neurology
  doi: 10.1212/01.wnl.0000201252.57661.e1
– volume: 447
  start-page: 1081
  year: 2007
  ident: 676_CR28
  publication-title: Nature
  doi: 10.1038/nature05865
– volume: 30
  start-page: 563
  year: 1991
  ident: 676_CR50
  publication-title: Ann Neurol
  doi: 10.1002/ana.410300409
– volume: 486
  start-page: 235
  year: 2010
  ident: 676_CR160
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2010.09.061
– volume: 387
  start-page: 2045
  year: 2022
  ident: 676_CR251
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2209254
– volume: 103
  start-page: 10793
  year: 2006
  ident: 676_CR280
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0602493103
– volume: 136
  start-page: 607
  year: 2018
  ident: 676_CR272
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-018-1873-4
– volume: 119
  start-page: 689
  year: 2010
  ident: 676_CR7
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-010-0664-3
– volume: 285
  start-page: 7334
  year: 2010
  ident: 676_CR161
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M109.061051
– volume: 38
  start-page: 515
  year: 2006
  ident: 676_CR55
  publication-title: Nat Genet
  doi: 10.1038/ng1769
– volume: 64
  start-page: 555
  year: 2008
  ident: 676_CR124
  publication-title: Ann Neurol
  doi: 10.1002/ana.21492
– volume: 278
  start-page: 44552
  year: 2003
  ident: 676_CR150
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M304517200
– volume: 9
  start-page: 5008
  year: 2018
  ident: 676_CR22
  publication-title: Nat Commun
  doi: 10.1038/s41467-018-07416-2
– volume: 157
  start-page: 401
  year: 2000
  ident: 676_CR66
  publication-title: Am J Pathol
  doi: 10.1016/S0002-9440(10)64553-1
– volume: 485
  start-page: 251
  year: 2012
  ident: 676_CR179
  publication-title: Nature
  doi: 10.1038/nature10992
– volume: 35
  start-page: 1854
  year: 2020
  ident: 676_CR88
  publication-title: Mov Disord
  doi: 10.1002/mds.28238
– volume: 240
  start-page: 44
  year: 2013
  ident: 676_CR167
  publication-title: Exp Neurol
  doi: 10.1016/j.expneurol.2012.11.007
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Snippet Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic Parkinson’s disease (PD). However, strategies aimed at ameliorating...
Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic Parkinson's disease (PD). However, strategies aimed at ameliorating...
Abstract Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic Parkinson’s disease (PD). However, strategies aimed at...
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SubjectTerms Adenosine triphosphate
Antioxidants
Antioxidants - metabolism
Antioxidants - therapeutic use
Bioenergetics
Brain
Chelating agents
Clinical trials
Diabetes mellitus
Electron transport
Electron transport chain
Exenatide
Genotype & phenotype
Health aspects
Homeostasis
Humans
Liraglutide
Mitochondria
Mitochondria - metabolism
Mitochondrial dysfunction
Movement disorders
MPTP
Neurodegeneration
Neurodegenerative diseases
Neurons
Neurophysiology
Oxidative Stress
Parkinson Disease - metabolism
Parkinson's disease
Pathogenesis
Pathology
Quality control
Quality management
Synuclein
Transmitters
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Title Mitochondrial dysfunction in Parkinson’s disease – a key disease hallmark with therapeutic potential
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Volume 18
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