Krtap16, Characterization of a New Hair Keratin-associated Protein (KAP) Gene Complex on Mouse Chromosome 16 and Evidence for Regulation by Hoxc13

• Published in: The Journal of biological chemistry Vol. 279; no. 49; pp. 51524 - 51533
• Main Authors: Pruett, Nathanael D., Tkatchenko, Tatiana V., Jave-Suarez, Luis, Jacobs, Donna F., Potter, Christopher S., Tkatchenko, Andrei V., Schweizer, Jürgen, Awgulewitsch, Alexander
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.12.2004; American Society for Biochemistry and Molecular Biology
• Subjects: Amino Acid Motifs; Amino Acid Sequence; Animals; Binding Sites; Blotting, Northern; Carrier Proteins - chemistry; Carrier Proteins - genetics; Chromosome Mapping; Chromosomes, Human, Pair 21; Conserved Sequence; DNA - metabolism; DNA, Complementary - metabolism; Gene Expression Regulation; Hair - metabolism; Homeodomain Proteins - physiology; Humans; Immunohistochemistry; Keratins - chemistry; Keratins - metabolism; Mice; Models, Genetic; Molecular Sequence Data; Multigene Family; Oligonucleotides - chemistry; Phylogeny; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Time Factors

Intermediate filament (IF) keratins and keratin-associated proteins (KAPs) are principal structural components of hair and encoded by members of multiple gene families. The severe hair growth defects observed upon aberrant expression of certain keratin and KAP genes in both mouse and man suggest tha...