Olmesartan attenuates the development of heart failure after experimental autoimmune myocarditis in rats through the modulation of ANG 1–7 mas receptor - Sukumaran, Vijayakumar; Veeraveedu, Punniyakoti T.; Gurusamy, Narasimman; Lakshmanan, Arun Prasath; Yamaguchi, Ken’ichi; Ma, Meilei; Suzuki, Kenji; Nagata, Masaki; Takagi, Ritsuo; Kodama, Makoto; Watanabe, Kenichi (Molecular and cellular endocrinology, 2012)
Keywords: Angiotensin 1–7; Angiotensin I - genetics; Angiotensin I - metabolism; Angiotensin II Type 1 Receptor Blockers - pharmacology; Angiotensin-converting enzyme-2; Angiotensin-II; Animals; apoptosis; Apoptosis - drug effects; Autoimmune Diseases - drug therapy; Autoimmune Diseases - metabolism; cardioprotective effect; Cardiotonic Agents - pharmacology; endoplasmic reticulum; Endoplasmic Reticulum Stress - drug effects; Experimental autoimmune myocarditis; gene expression regulation; heart failure; Heart Failure - drug therapy; Heart Failure - metabolism; Imidazoles - pharmacology; inflammation; Inflammation - drug therapy; JNK Mitogen-Activated Protein Kinases - biosynthesis; MAPK signaling pathways; Membrane Glycoproteins; messenger RNA; mitogen-activated protein kinase; myocarditis; Myocarditis - drug therapy; Myocarditis - immunology; Myocarditis - metabolism; NAD(P)H oxidase (H2O2-forming); NADPH Oxidase 4; NADPH Oxidases - biosynthesis; Olmesartan; oxidative stress; Oxidative Stress - drug effects; p38 Mitogen-Activated Protein Kinases - biosynthesis; Peptide Fragments - genetics; Peptide Fragments - metabolism; peptidyl-dipeptidase A; Peptidyl-Dipeptidase A - biosynthesis; Peptidyl-Dipeptidase A - genetics; phosphatidylinositol 3-kinase; Phosphatidylinositol 3-Kinases - biosynthesis; Phosphoproteins - biosynthesis; Proto-Oncogene Proteins c-akt - biosynthesis; Rats; Rats, Inbred Lew; Receptor, Angiotensin, Type 1 - metabolism; Receptors, Interleukin-1; renin; RNA, Messenger - biosynthesis; signal transduction; Tetrazoles - pharmacology; therapeutics; DHE; ANG-II; RAS; JNK; LVP; Angiotensin-II; LVDd; AT2R; LVEDP; Angiotensin 1–7; Experimental autoimmune myocarditis; PI3K; NADPH oxidase; LVDs; Olmesartan; MAPKAPK-2; MAPK signaling pathways; ANG (1–7); AT1R; RIA; MAPK; EAM; Angiotensin-converting enzyme-2; ACE-2; ARBs; ELISA