Ebselen and analogs as inhibitors of Bacillus anthracis thioredoxin reductase and bactericidal antibacterials targeting Bacillus species, Staphylococcus aureus and Mycobacterium tuberculosis

• Published in: Biochimica et biophysica acta Vol. 1860; no. 6; pp. 1265 - 1271
• Main Authors: Gustafsson, Tomas N., Osman, Harer, Werngren, Jim, Hoffner, Sven, Engman, Lars, Holmgren, Arne
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2016
• Subjects: Amino Acid Sequence; anthrax; Anti-Bacterial Agents - pharmacology; antibacterial properties; Antibiotic resistance; antibiotics; Azoles - pharmacology; Bacillus - drug effects; Bacillus anthracis; Bacillus anthracis - enzymology; Bacillus cereus; Bacillus subtilis; bacteria; Drug target; drugs; humans; inhibitory concentration 50; mechanism of action; Microbial Sensitivity Tests; minimum inhibitory concentration; Molecular Sequence Data; mortality; mutants; Mycobacterium tuberculosis; Mycobacterium tuberculosis - drug effects; Organoselenium Compounds - pharmacology; pathogens; Redox biology; Staphylococcus aureus; Staphylococcus aureus - drug effects; Thioredoxin reductase; Thioredoxin-Disulfide Reductase - antagonists & inhibitors; Drug target; Redox biology; Mycobacterium tuberculosis; Thioredoxin reductase; Staphylococcus aureus; Antibiotic resistance

Bacillus anthracis is the causative agent of anthrax, a disease associated with a very high mortality rate in its invasive forms. We studied a number of ebselen analogs as inhibitors of B. anthracis thioredoxin reductase and their antibacterial activity on Bacillus subtilis, Staphylococcus aureus, B...