Oxidative stress and genotoxicity in 1,4-dioxane liver toxicity as evidenced in a mouse model of glutathione deficiency - Chen, Ying; Wang, Yewei; Charkoftaki, Georgia; Orlicky, David J.; Davidson, Emily; Wan, Fengjie; Ginsberg, Gary; Thompson, David C.; Vasiliou, Vasilis (The Science of the total environment, 2022)
Keywords: Animals; byproducts; Canada; carcinogenicity; carcinogens; CYP2E1; cytotoxicity; Dioxanes; DNA Damage; DNA repair; environment; Follow-Up Studies; genotoxicity; glutamate-cysteine ligase; glutathione; Glutathione - metabolism; hepatotoxicity; homeostasis; lipid peroxidation; liver; Liver - metabolism; Liver carcinogenicity; maximum contaminant level; Mechanism of action; Mice; Mice, Knockout; oxidation; Oxidative DNA damage; Oxidative Stress; risk; stabilizers; stress response; subchronic exposure; United States Environmental Protection Agency; Water contaminant; Canada; H2AX; Q-ToF; IHC; ALT; WB; Gclc; QC; DX; 4-HNE; NRF2; γH2AX; Liver carcinogenicity; ESI; Gclm; Mechanism of action; GSH; MOA; 8-OHdG; GSSG; AST; PWSs; H&E; IARC; UCMR3; Oxidative DNA damage; GCL; RC; Water contaminant; TCA; BMDL-50; ATSDR; UPLC; MCL; TCE; ROS; CYP2E1; HEAA