Distinct characteristics of two types of alternative lengthening of telomeres in mouse embryonic stem cells

• Published in: Nucleic Acids Research Vol. 51; no. 17; pp. 9122 - 9143
• Main Authors: Sung, Sanghyun, Kim, Eunkyeong, Niida, Hiroyuki, Kim, Chuna, Lee, Junho
• Format: Journal Article
• Language: English
• Published: England Oxford University Press (OUP) 22.09.2023; Oxford University Press
• Subjects: Animals; Genome Integrity, Repair and; Genome Integrity, Repair and Replication; Mice; Mouse Embryonic Stem Cells; Mutation; Telomerase; Telomere; Telomere Homeostasis

Abstract Telomere length must be maintained in actively dividing cells to avoid cellular arrest or death. In the absence of telomerase activity, activation of alternative lengthening of telomeres (ALT) allows the maintenance of telomeric length and prolongs the cellular lifespan. Our previous studie...