Simple Viewing Tests Can Detect Eye Movement Abnormalities That Distinguish Schizophrenia Cases from Controls with Exceptional Accuracy

• Published in: Biological psychiatry (1969) Vol. 72; no. 9; pp. 716 - 724
• Main Authors: Benson, Philip J., Beedie, Sara A., Shephard, Elizabeth, Giegling, Ina, Rujescu, Dan, St. Clair, David
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.11.2012; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Biological and medical sciences; Case-Control Studies; Classification; Eye Movements - physiology; eye-movement phenotype; Female; Humans; Male; Medical sciences; Models, Statistical; neural network; Neuropsychological Tests - statistics & numerical data; Ocular Motility Disorders - complications; Ocular Motility Disorders - physiopathology; predictive model; Predictive Value of Tests; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; risk marker; Schizophrenia; Schizophrenia - complications; Schizophrenia - diagnosis; Schizophrenia - physiopathology; Smoking - physiopathology; Time Factors; eye-movement phenotype; predictive model; schizophrenia; neural network; risk marker; Classification; Prediction; Schizophrenia; Case control study; Neural network; Abnormal movement; Eye movement; Psychosis; Phenotype; Accuracy; Models

We have investigated which eye-movement tests alone and combined can best discriminate schizophrenia cases from control subjects and their predictive validity. A training set of 88 schizophrenia cases and 88 controls had a range of eye movements recorded; the predictive validity of the tests was the...