Cellular depletion of major cathepsin proteases reveals their concerted activities for lysosomal proteolysis - Gallwitz, Lisa; Bleibaum, Florian; Voss, Matthias; Schweizer, Michaela; Spengler, Katharina; Winter, Dominic; Zöphel, Frederic; Müller, Stephan; Lichtenthaler, Stefan; Damme, Markus; Saftig, Paul (Cellular and molecular life sciences : CMLS, 2024)
Keywords: albumins; Alzheimer's disease; amyloid; Amyloid beta-Protein Precursor - genetics; Amyloid beta-Protein Precursor - metabolism; Amyloid precursor protein; Aspartic endopeptidase; aspartic proteinases; Autophagy; Biochemistry; Biodegradation; Biomedical and Life Sciences; Biomedicine; Cathepsin L; Cathepsin L - genetics; Cathepsin L - metabolism; Cathepsins; Cathepsins - genetics; Cathepsins - metabolism; Cell Biology; Cell Line, Tumor; Cleavage; cysteine proteinases; Degradation; Depletion; Endocytosis; Fragments; Functionals; HeLa Cells; Humans; Life Sciences; Lysosomes; Lysosomes - metabolism; Membrane proteins; Original; Original Article; Peptides; protein degradation; Proteins; Proteolysis; proteome; Proteomes; Redundancy; Substrates; Proteolysis; Protease network; Lysosome; Proteomics; Cathepsins; Bulk proteolysis; Autophagy; Amyloid precursor protein