A Corticotropin Releasing Factor Network in the Extended Amygdala for Anxiety

• Published in: The Journal of neuroscience Vol. 39; no. 6; pp. 1030 - 1043
• Main Authors: Pomrenze, Matthew B., Tovar-Diaz, Jorge, Blasio, Angelo, Maiya, Rajani, Giovanetti, Simone M., Lei, Kelly, Morikawa, Hitoshi, Hopf, F. Woodward, Messing, Robert O.
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 06.02.2019
• Subjects: Amygdala; Amygdala - physiopathology; Animals; Anxiety; Anxiety - physiopathology; Anxiety - psychology; Behavior, Animal; Circuits; Corticosterone - metabolism; Corticotropin-releasing hormone; Corticotropin-Releasing Hormone - genetics; Cre recombinase; Human behavior; Interpersonal Relations; Male; Nerve Net - physiopathology; Neural networks; Neurons; Neurons - physiology; Rats; Rats, Wistar; Receptors; Receptors, Corticotropin-Releasing Hormone - metabolism; Septal Nuclei - physiopathology; Stress, Psychological - physiopathology; Stress, Psychological - psychology; Stria terminalis; Subpopulations; anxiety; bed nucleus of the stria terminals; amygdala; corticotropin releasing factor; chemogenetics

The central amygdala (CeA) is important for fear responses to discrete cues. Recent findings indicate that the CeA also contributes to states of sustained apprehension that characterize anxiety, although little is known about the neural circuitry involved. The stress neuropeptide corticotropin relea...