A Nonenzymatic Modification of the Amino-terminal Domain of Histone H3 by Bile Acid Acyl Adenylate

• Published in: The Journal of biological chemistry Vol. 279; no. 53; pp. 55034 - 55041
• Main Authors: Mano, Nariyasu, Kasuga, Kie, Kobayashi, Norihiro, Goto, Junichi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 31.12.2004; American Society for Biochemistry and Molecular Biology
• Subjects: Amino Acid Sequence; Bile Acids and Salts - chemistry; Chromatography, High Pressure Liquid; Deoxycholic Acid - chemistry; DNA Adducts; Histones - chemistry; Histones - metabolism; Humans; Ions; Lysine - chemistry; Models, Chemical; Models, Molecular; Molecular Sequence Data; Protein Structure, Tertiary; Recombinant Proteins - chemistry; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Temperature

Although it has been proposed that the secondary bile acids, deoxycholic acid and lithocholic acid, increase the number of aberrant crypt foci in the colon and may act as colon tumor promoters, there is little evidence detailing their mechanism of action. Histones play an important role in controlli...