Association between gene promoter methylation of the one-carbon metabolism pathway and serum folate among patients with hyperhomocysteinemia

• Published in: European journal of clinical nutrition Vol. 74; no. 12; pp. 1677 - 1684
• Main Authors: Huang, Xiaowen, Zhao, Qinglin, Li, Dankang, Ren, Bingnan, Yue, Limin, Shi, Fengxian, Wang, Xiliang, Zheng, Caifang, Chen, Xiaorui, Zhang, Chengda, Zhang, Weidong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2020; Nature Publishing Group
• Subjects: 38; 38/22; 45/22; 45/77; 631/208/176; 692/499; Age; Age factors in disease; Betaine; Betaine-homocysteine S-methyltransferase; Carbon; Cardiovascular diseases; CBS gene; Clinical Nutrition; Complications and side effects; Correlation; CpG islands; Cystathionine b-synthase; Development and progression; Diabetes; Diabetes mellitus; DNA methylation; Enzymes; Epidemiology; Folic acid; Folic acid deficiency; Genes; Genetic aspects; Health aspects; Heart diseases; Homocysteine; Homocystinuria; Hyperhomocysteinemia; Hypertension; Internal Medicine; Males; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolism; Methionine; Methylation; Methyltransferase; Pathogenesis; Promoters (Genetics); Public Health; Risk analysis; Risk factors; Vitamin B; Vitamin deficiency; China

Aim Age and lower folate concentrations are well-known risk factors for cardiovascular disease (CVD), but the potential roles of age and folate deficiency in hyperhomocysteinemia (HHcy), especially in HHcy patients with abnormal methylation levels of key enzyme genes promoter in homocysteinemia (Hcy...