Role of estrogen receptors in menstrual cycle–related neoangiogenesis and their influence on endothelial progenitor cell physiology

• Published in: Fertility and sterility Vol. 93; no. 1; pp. 220 - 228
• Main Authors: Foresta, Carlo, M.D, De Toni, Luca, B.S, Di Mambro, Antonella, M.D, Ferlin, Alberto, M.D, Perilli, Lisa, B.S, Bertuzzi, Ilaria, B.S, Galan, Alessandro, M.D, Zuccarello, Daniela, M.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 2010; Elsevier
• Subjects: Adult; Biological and medical sciences; Case-Control Studies; Cells, Cultured; CXCR4; Endometrium - blood supply; Endothelial Cells - immunology; Endothelial Cells - metabolism; Endothelial progenitor cell; Estradiol - blood; estrogen receptor; Estrogen Receptor alpha - blood; Estrogen Receptor alpha - genetics; Estrogen Receptor beta - blood; Estrogen Receptor beta - genetics; Female; Flow Cytometry; Fluorescent Antibody Technique; Gynecology. Andrology. Obstetrics; Humans; Immunoassay; Internal Medicine; Male; Matrix Metalloproteinase 9 - genetics; Medical sciences; Menopause - blood; menstrual cycle; Menstrual Cycle - metabolism; Middle Aged; MMP9; Neovascularization, Physiologic; Obstetrics and Gynecology; Receptors, CXCR4 - blood; Receptors, CXCR4 - genetics; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells - immunology; Stem Cells - metabolism; Time Factors; Young Adult; CXCR4; Endothelial progenitor cell; estrogen receptor; MMP9; menstrual cycle; Estrogen receptor; Endothelial cell; Menstrual cycle; Gynecology; Physiology; Obstetrics; CXCR4 chemokine receptor; Progenitor cell; Hormonal receptor

Objective To study whether estrogen receptors (ERs) are expressed in vitro and in vivo by female circulating endothelial progenitor cells (EPCs); and the role of ERs in the periodic vascular damage and repair that occurs during the menstrual cycle. Design Quantification of circulating progenitor cel...