The Cell Surface Glycoprotein CUB Domain-containing Protein 1 (CDCP1) Contributes to Epidermal Growth Factor Receptor-mediated Cell Migration

• Published in: The Journal of biological chemistry Vol. 287; no. 13; pp. 9792 - 9803
• Main Authors: Dong, Ying, He, Yaowu, de Boer, Leonore, Stack, M. Sharon, Lumley, John W., Clements, Judith A., Hooper, John D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 23.03.2012; American Society for Biochemistry and Molecular Biology
• Subjects: Antigens, CD - biosynthesis; Antigens, CD - genetics; Antigens, Neoplasm; Antineoplastic Agents - pharmacology; CDCP1; Cell Adhesion Molecules - biosynthesis; Cell Adhesion Molecules - genetics; Cell Biology; Cell Line, Tumor; Cell Migration; Cell Movement; Drug Resistance, Neoplasm - drug effects; Drug Resistance, Neoplasm - genetics; Epidermal Growth Factor - genetics; Epidermal Growth Factor - metabolism; Epidermal Growth Factor Receptor (egfr); ErbB Receptors - genetics; ErbB Receptors - metabolism; Female; Gene Expression Regulation, Neoplastic; Humans; Intercellular Junctions - genetics; Intercellular Junctions - metabolism; Intercellular Junctions - pathology; MAP Kinase Signaling System - drug effects; MAP Kinase Signaling System - genetics; Mutation; Neoplasm Proteins - biosynthesis; Neoplasm Proteins - genetics; Ovarian Cancer; Ovarian Neoplasms - drug therapy; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Protein Structure; Pseudopodia - genetics; Pseudopodia - metabolism; Pseudopodia - pathology; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; RNA, Neoplasm - biosynthesis; RNA, Neoplasm - genetics; Up-Regulation; Cell Migration; Ovarian Cancer; CDCP1; Protein Structure; Epidermal Growth Factor Receptor (egfr); Cell Biology

Epidermal growth factor (EGF) activation of the EGF receptor (EGFR) is an important mediator of cell migration, and aberrant signaling via this system promotes a number of malignancies including ovarian cancer. We have identified the cell surface glycoprotein CDCP1 as a key regulator of EGF/EGFR-ind...