Acetyl-CoA Carboxylase 2−/− Mutant Mice are Protected against Fatty Liver under High-fat, High-carbohydrate Dietary and de Novo Lipogenic Conditions

• Published in: The Journal of biological chemistry Vol. 287; no. 15; pp. 12578 - 12588
• Main Authors: Abu-Elheiga, Lutfi, Wu, Hongmei, Gu, Ziwei, Bressler, Rubin, Wakil, Salih J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.04.2012; American Society for Biochemistry and Molecular Biology
• Subjects: Acetyl-CoA Carboxylase - genetics; Acetyl-CoA Carboxylase - metabolism; Adiposity; Animals; Apolipoproteins C - metabolism; Blood Glucose; Body Weight; Diet, High-Fat - adverse effects; Dietary Carbohydrates - adverse effects; Fasting; Fatty Acid Metabolism; Fatty Acid Oxidation; Fatty Acid Synthase; Fatty Acid Synthases - metabolism; Fatty Liver - blood; Fatty Liver - enzymology; Fatty Liver - etiology; Gene Expression; Gene Expression Regulation; Gene Knockout; Lipid Droplet; Lipid Metabolism; Lipids; Lipids - blood; Lipogenesis; Lipotoxicity; Liver - enzymology; Liver - metabolism; Liver - pathology; Male; Metabolism; Mice; Mice, 129 Strain; Mice, Knockout; Organ Size; Proto-Oncogene Proteins c-akt - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; Transcription, Genetic; Gene Expression; Fatty Acid Synthase; Liver Metabolism; Fatty Acid Metabolism; Lipid Droplet; Fatty Acid Oxidation; Lipids; Lipid Metabolism; Gene Knockout; Lipotoxicity

Hepatic fat accumulation resulting from increased de novo fatty acid synthesis leads to hepatic steatosis and hepatic insulin resistance. We have shown previously that acetyl-CoA carboxylase 2 (Acc2−/−) mutant mice, when fed a high-fat (HF) or high-fat, high-carbohydrate (HFHC) diet, are protected a...