Antinociceptive effects of intrathecally administered endothelin-1 in mice

• Published in: Neuroscience letters Vol. 153; no. 1; pp. 69 - 72
• Main Authors: Kamei, Junzo, Hitosugi, Hideki, Kawashima, Naoya, Misawa, Miwa, Kasuya, Yutaka
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 16.04.1993; Elsevier
• Subjects: Analgesics; Animals; Antinociception; Biological and medical sciences; Ca 2+ channel antagonist; Endothelin-1; Endothelins - antagonists & inhibitors; Endothelins - pharmacology; Hot Temperature; Injections, Spinal; Male; Medical sciences; Mice; Mice, Inbred ICR; Mouse; Naloxone; Naltrindole; Neuropharmacology; Nociceptors - drug effects; Pain Measurement; Pharmacology. Drug treatments; Time Factors; Verapamil - pharmacology; Ca 2+ channel antagonist; Antinociception; Naltrindole; Naloxone; Mouse; Endothelin-1; Spinal cord; Calcium; Opiate receptor δ; Rodentia; Central nervous system; Ionic channel; Endothelin 1; Opioid peptide; Intrathecal administration; Analgesia; Vertebrata; Mammalia; Analgesic; Animal
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/0304-3940(93)90079-Z

Intrathecal administration of endothelin-1 (ET-1) produced dose-dependent antinociceptive effects in the tail-flick test. The antinociceptive effects of ET-1 were attenuated significantly by pretreatment with naloxone and the δ receptor-selective antagonist naltrindole. The antinociceptive effects of ET-1 were also significantly attenuated by pretreatment with verapamil, an L-type Ca 2+-channel blocker. These results suggest that the mechanism underlying the antinociceptive effects of ET-1 involves mediation, at least in part, by Ca 2+-induced release of endogenous opioids, which act on δ-opioid receptors.