ERK5 signalling in prostate cancer promotes an invasive phenotype

• Published in: British journal of cancer Vol. 104; no. 4; pp. 664 - 672
• Main Authors: Ramsay, A K, McCracken, S R C, Soofi, M, Fleming, J, Yu, A X, Ahmad, I, Morland, R, Machesky, L, Nixon, C, Edwards, D R, Nuttall, R K, Seywright, M, Marquez, R, Keller, E, Leung, H Y
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.02.2011; Nature Publishing Group
• Subjects: 631/80/84/2336; 631/80/86; 692/699/67/589/466; Androgens; Animals; Benzamides - pharmacology; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Cancer therapies; Cell growth; Cell Movement - drug effects; Cell Movement - genetics; Cell Proliferation - drug effects; Cells, Cultured; Drug Evaluation, Preclinical; Drug Resistance; Epidemiology; Gene Expression Regulation, Neoplastic - drug effects; Gene Expression Regulation, Neoplastic - genetics; Genotype & phenotype; Humans; Kinases; Male; MAP Kinase Kinase 5 - genetics; MAP Kinase Kinase 5 - metabolism; MAP Kinase Kinase 5 - physiology; MAP Kinase Signaling System - drug effects; MAP Kinase Signaling System - genetics; MAP Kinase Signaling System - physiology; Medical prognosis; Medical research; Medical sciences; Metastasis; Mice; Mice, Nude; Mitogen-Activated Protein Kinase 7 - genetics; Mitogen-Activated Protein Kinase 7 - metabolism; Mitogen-Activated Protein Kinase 7 - physiology; Molecular Diagnostics; Molecular Medicine; Motility; Neoplasm Invasiveness; Nephrology. Urinary tract diseases; Oncology; Phenotype; Prostate cancer; Prostatic Hyperplasia - genetics; Prostatic Hyperplasia - metabolism; Prostatic Hyperplasia - pathology; Prostatic Neoplasms - genetics; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Protein Kinase Inhibitors - pharmacology; Proteins; RNA, Small Interfering - pharmacology; Transfection; Transplantation, Heterologous; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland; United Kingdom > UK; United States > US; invasive phenotype; prostate cancer; signalling; Urinary system disease; Prostate disease; Malignant tumor; Signal transduction; Extracellular signal-regulated protein kinase 5; Phenotype; Cancerology; Invasive cancer; Male genital diseases; Prostate cancer; Cancer

Background: Aberrant mitogen/extracellular signal-regulated kinase 5 (MEK5)–extracellular signal-regulated protein kinase 5 (ERK5)-mediated signalling has been implicated in a number of tumour types including prostate cancer (PCa). The molecular basis of ERK5-driven carcinogenesis and its clinical r...